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Gregory Riggins

M.D., Ph.D.
410.502.2908 (p)
Interests

Neurological Surgery

Titles

Professor of Neurosurgery and Oncology
Irving J. Sherman Research Professor


 

Schools\Degrees

Dr. Riggins received his medical and Ph.D. degrees from Emory University, where he graduated from the Medical Scientist Training Program. He entered directly into a research fellowship in the Johns Hopkins Oncology Department.

Research Summary

Professor of Neurosurgery and Oncology at Johns Hopkins, Dr. Gregory Riggins directs the Brain Cancer Biology and Therapy Research Laboratory. The main goal of his research is to locate and evaluate molecular targets for new brain tumor therapies. A major component of this research is the location of new small molecules.

Dr. Riggins is the inaugural recipient of the Irving J. Sherman, M.D. Research Professorship in Neurosurgery Research. He is author of more than 6O research publications. He has worked with the Cancer Genome Anatomy Project to coordinate a large cancer gene expression database, SAGE Genie.

 

Journal Citations

Dixit, V.D.; Weeraratna, A.T.; Yang, H.; Bertak, D.; Cooper-Jenkins, A.; Riggins, G.J.; Eberhart, C.G.; Taub, D.D. Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. The Journal of biological chemistry. 2006 Jun 16;281(24):16681-16690.
Gallia, G.L.; Rand, V.; Siu, I.M.; Eberhart, C.G.; James, C.D.; Marie, S.K.; Oba-Shinjo, S.M.; Carlotti, C.G.; Caballero, O.L.; Simpson, A.J.; Brock, M.V.; Massion, P.P.; Carson, B.S., Sr.; Riggins, G.J. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res. 2006 Oct;4(10):709-714.
Hunter, C.; Smith, R.; Cahill, D.P.; Stephens, P.; Stevens, C.; Teague, J.; Greenman, C.; Edkins, S.; Bignell, G.; Davies, H.; O'Meara, S.; Parker, A.; Avis, T.; Barthorpe, S.; Brackenbury, L.; Buck, G.; Butler, A.; Clements, J.; Cole, J.; Dicks, E.; Forbes, S.; Gorton, M.; Gray, K.; Halliday, K.; Harrison, R.; Hills, K.; Hinton, J.; Jenkinson, A.; Jones, D.; Kosmidou, V.; Laman, R.; Lugg, R.; Menzies, A.; Perry, J.; Petty, R.; Raine, K.; Richardson, D.; Shepherd, R.; Small, A.; Solomon, H.; Tofts, C.; Varian, J.; West, S.; Widaa, S.; Yates, A.; Easton, D.F.; Riggins, G.; Roy, J.E.; Levine, K.K.; Mueller, W.; Batchelor, T.T.; Louis, D.N.; Stratton, M.R.; Futreal, P.A.; Wooster, R. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res. 2006 Apr 15;66(8):3987-3991.
Kuan, C.T.; Wakiya, K.; Dowell, J.M.; Herndon, J.E., 2nd; Reardon, D.A.; Graner, M.W.; Riggins, G.J.; Wikstrand, C.J.; Bigner, D.D. Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clinical Cancer Res:An Official Journal of the American Association for Cancer Res. 2006 Apr 1;12(7 Pt 1):1970-1982.
Wood, L.D.; Calhoun, E.S.; Silliman, N.; Ptak, J.; Szabo, S.; Powell, S.M.; Riggins, G.J.; Wang, T.L.; Yan, H.; Gazdar, A.; Kern, S.E.; Pennacchio, L.; Kinzler, K.W.; Vogelstein, B.; Velculescu, V.E. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat. 2006 Oct;27(10):1060-1061.
Beaty, R.M.; Edwards, J.B.; Boon, K.; Siu, I.M.; Conway, J.E.; Riggins, G.J. PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium. Journal of neuro-oncology. 2007 Feb;81(3):241-248.
Sawanyawisuth, K.; Wongkham, C.; Pairojkul, C.; Saeseow, O.T.; Riggins, G.J.; Araki, N.; Wongkham, S. Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target. Acta Oncologica (Stockholm, Sweden). 2007;46(3):378-385.
Trembath, D.G.; Lal, A.; Kroll, D.J.; Oberlies, N.H.; Riggins, G.J. A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII. Molecular cancer. 2007 Apr 16;6:30.
Parsons, D.W.; Jones, S.; Zhang, X.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Siu, I.M.; Gallia, G.L.; Olivi, A.; McLendon, R.; Rasheed, B.A.; Keir, S.; Nikolskaya, T.; Nikolsky, Y.; Busam, D.A.; Tekleab, H.; Diaz, L.A., Jr.; Hartigan, J.; Smith, D.R.; Strausberg, R.L.; Marie, S.K.; Shinjo, S.M.; Yan, H.; Riggins, G.J.; Bigner, D.D.; Karchin, R.; Papadopoulos, N.; Parmigiani, G.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008 Sep 26;321(5897):1807-1812.
Siu, I.M.; Bai, R.; Gallia, G.L.; Edwards, J.B.; Tyler, B.M.; Eberhart, C.G.; Riggins, G.J. Coexpression of neuronatin splice forms promotes medulloblastoma growth. Neuro Oncol. 2008 Oct;10(5):716-724.
Yi, J.M.; Tsai, H.C.; Glockner, S.C.; Lin, S.; Ohm, J.E.; Easwaran, H.; James, C.D.; Costello, J.F.; Riggins, G.; Eberhart, C.G.; Laterra, J.; Vescovi, A.L.; Ahuja, N.; Herman, J.G.; Schuebel, K.E.; Baylin, S.B. Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res. 2008 Oct 1;68(19):8094-8103.
Duncan, C.G.; Leary, R.J.; Lin, J.C.; Cummins, J.; Di, C.; Schaefer, C.F.; Wang, T.L.; Riggins, G.J.; Edwards, J.; Bigner, D.; Kopelovich, L.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Yan, H. Identification of microbial DNA in human cancer. BMC Med Genomics. 2009;2:22.
Gallia, G.L.; Tyler, B.M.; Hann, C.L.; Siu, I.M.; Giranda, V.L.; Vescovi, A.L.; Brem, H.; Riggins, G.J. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Molecular cancer therapeutics. 2009 Feb;8(2):386-393.
Loilome, W.; Joshi, A.D.; Ap Rhys, C.M.; Piccirillo, S.; Angelo, V.L.; Gallia, G.L.; Riggins, G.J. Glioblastoma cell growth is suppressed by disruption of fibroblast growth factor pathway signaling. J Neurooncol. 2009 Apr 2;94:359-366.
Yan, H.; Parsons, D.W.; Jin, G.; McLendon, R.; Rasheed, B.A.; Yuan, W.; Kos, I.; Batinic-Haberle, I.; Jones, S.; Riggins, G.J.; Friedman, H.; Friedman, A.; Reardon, D.; Herndon, J.; Kinzler, K.W.; Velculescu, V.E.; Vogelstein, B.; Bigner, D.D. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009 Feb 19;360(8):765-773.
Bai, R.; Siu, I.M.; Tyler, B.M.; Staedtke, V.; Gallia, G.L.; Riggins, G.J. Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas. Neuro-oncology. 2010 (Journal Article).
Hector, A.; Montgomery, E.A.; Karikari, C.; Canto, M.; Dunbar, K.B.; Wang, J.S.; Feldmann, G.; Hong, S.M.; Haffner, M.C.; Meeker, A.K.; Holland, S.J.; Yu, J.; Heckrodt, T.J.; Zhang, J.; Ding, P.; Goff, D.; Singh, R.; Roa, J.C.; Marimuthu, A.; Riggins, G.J.; Eshleman, J.R.; Nelkin, B.D.; Pandey, A.; Maitra, A. The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma. Cancer Biol Ther. 2010 Nov 29;10(10):1009-1018.
Kuan, C.T.; Wakiya, K.; Herndon, J.E., 2nd; Lipp, E.S.; Pegram, C.N.; Riggins, G.J.; Rasheed, A.; Szafranski, S.E.; McLendon, R.E.; Wikstrand, C.J.; Bigner, D.D. MRP3: a molecular target for human glioblastoma multiforme immunotherapy. BMC cancer. 2010;10(Journal Article):468.
Parsons, D.W.; Li, M.; Zhang, X.; Jones, S.; Leary, R.J.; Lin, J.C.; Boca, S.M.; Carter, H.; Samayoa, J.; Bettegowda, C.; Gallia, G.L.; Jallo, G.I.; Binder, Z.A.; Nikolsky, Y.; Hartigan, J.; Smith, D.R.; Gerhard, D.S.; Fults, D.W.; Vandenberg, S.; Berger, M.S.; Marie, S.K.; Shinjo, S.M.; Clara, C.; Phillips, P.C.; Minturn, J.E.; Biegel, J.A.; Judkins, A.R.; Resnick, A.C.; Storm, P.B.; Curran, T.; He, Y.; Rasheed, B.A.; Friedman, H.S.; Keir, S.T.; McLendon, R.; Northcott, P.A.; Taylor, M.D.; Burger, P.C.; Riggins, G.J.; Karchin, R.; Parmigiani, G.; Bigner, D.D.; Yan, H.; Papadopoulos, N.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E. The Genetic Landscape of the Childhood Cancer Medulloblastoma. Science. 2010 Dec 16.
Seltzer, M.J.; Bennett, B.D.; Joshi, A.D.; Gao, P.; Thomas, A.G.; Ferraris, D.V.; Tsukamoto, T.; Rojas, C.J.; Slusher, B.S.; Rabinowitz, J.D.; Dang, C.V.; Riggins, G.J. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010 Nov 15;70(22):8981-8987.
Siu, I.M.; Tyler, B.M.; Chen, J.X.; Eberhart, C.G.; Thomale, U.W.; Olivi, A.; Jallo, G.I.; Riggins, G.J.; Gallia, G.L. Establishment of a human glioblastoma stemlike brainstem rodent tumor model. Journal of neurosurgeryPediatrics. 2010;6(1):92-97.

 

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