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Dr. Ron Mease

Associate Professor
(410) 955-6500 (p)
Interests

Radiology and Radiological Sciences

Titles

Associate Professor Radiology

Research Summary

Dr. Ron Mease is an organic chemist with 25 years experience in the production and purification of radionuclides, and in the design, synthesis, purification, and testing of radiopharmaceuticals and radiochemicals for imaging and radiotherapy. Radiolabeled agents prepared have ranged from monoclonal antibody conjugates (radiometal labeled) to small molecules (radiometal or radiohalogen labeled). Current work includes the design and synthesis of Prostate Specific Membrane Antigen (PSMA) and Prostate Specific Antigen (PSA) based agents for Prostate Cancer imaging (PET, SPECT, and Optical) and radiotherapy.
 

Journal Citations

Banerjee, S.R.; Foss, C.A.; Castanares, M.; Mease, R.C.; Byun, Y.; Fox, J.J.; Hilton, J.; Lupold, S.E.; Kozikowski, A.P.; Pomper, M.G. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem. 2008 Aug 14;51(15):4504-4517.

Barinka, C.; Byun, Y.; Dusich, C.L.; Banerjee, S.R.; Chen, Y.; Castanares, M.; Kozikowski, A.P.; Mease, R.C.; Pomper, M.G.; Lubkowski, J. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization. Journal of medicinal chemistry. 2008 Dec 25;51(24):7737-7743.

Chandran, S.S.; Banerjee, S.R.; Mease, R.C.; Pomper, M.G.; Denmeade, S.R. Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA). Cancer biology & therapy. 2008 Jun;7(6):974-982.

Chen, Y.; Foss, C.A.; Byun, Y.; Nimmagadda, S.; Pullambhatla, M.; Fox, J.J.; Castanares, M.; Lupold, S.E.; Babich, J.W.; Mease, R.C.; Pomper, M.G. Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer. J Med Chem. 2008 Dec 25;51(24):7933-7943.

Mease, R.C.; Dusich, C.L.; Foss, C.A.; Ravert, H.T.; Dannals, R.F.; Seidel, J.; Prideaux, A.; Fox, J.J.; Sgouros, G.; Kozikowski, A.P.; Pomper, M.G. N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Clin Cancer Res. 2008 May 15;14(10):3036-3043.

Chen, Y.; Dhara, S.; Banerjee, S.R.; Byun, Y.; Pullambhatla, M.; Mease, R.C.; Pomper, M.G. A low molecular weight PSMA-based fluorescent imaging agent for cancer. Biochem Biophys Res Commun. 2009 Dec 18;390(3):624-629.

LeBeau, A.M.; Banerjee, S.R.; Pomper, M.G.; Mease, R.C.; Denmeade, S.R. Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer. Bioorganic & medicinal chemistry. 2009 Jul 15;17(14):4888-4893.

Wang, H.; Byun, Y.; Barinka, C.; Pullambhatla, M.; Bhang, H.E.; Fox, J.J.; Lubkowski, J.; Mease, R.C.; Pomper, M.G. Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorg Med Chem Lett. 2009 Oct 24.

Wang, H.; Pullambhatla, M.; Guilarte, T.R.; Mease, R.C.; Pomper, M.G. Synthesis of [(125)I]iodoDPA-713: a new probe for imaging inflammation. Biochem Biophys Res Commun. 2009 Nov 6;389(1):80-83.

Banerjee, S.R.; Pullambhatla, M.; Byun, Y.; Nimmagadda, S.; Green, G.; Fox, J.J.; Horti, A.; Mease, R.C.; Pomper, M.G. 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer. J Med Chem. 2010 Jul 22;53(14):5333-5341.
Gao, Y.; Wang, H.; Mease, R.C.; Pomper, M.G.; Horti, A.G. Improved Syntheses of Precursors for PET Radioligands [F]XTRA and [F]AZAN. Tetrahedron Lett. 2010 Oct 6;51(40):5333-5335.

Mease, R.C. Radionuclide based imaging of prostate cancer. Curr Top Med Chem. 2010;10(16):1600-1616.

Wang, H.; Byun, Y.; Barinka, C.; Pullambhatla, M.; Bhang, H.E.; Fox, J.J.; Lubkowski, J.; Mease, R.C.; Pomper, M.G. Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorg Med Chem Lett. 2010 Jan 1;20(1):392-397.

Banerjee S, Pullambhatla M, Byun Y, Nimmagadda S, Green G, Fox J, Horti A, Mease RC, Pomper, MG. 2010. 68Ga-Labeled Inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer. J. Med. Chem. 53(14) 5333-5341.

LeBeau AM, Banerjee SR; Pomper, MG, Mease RC, Denmeade SR. 2009. Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer. Bioorganic & Medicinal Chemistry 17(14):4888-4893.

Wang H, Pullambhatla M, Guilarte TR, Mease RC, Pomper MG. 2009. Synthesis of [125I]iodoDPA-713: A new probe for imaging inflammation. Biochemical and Biophysical Research Communications (1)389: 80-83.

Chen Y, Dhara S, Banerjee SR, Byun Y, Pullambhatla M, Mease RC, Pomper MG. 2009. A low Molecular weight PSMA-based fluorescent imaging agent for cancer. Biochemical and Biophysical Research Communications 390(3) 624-629.

Mease RC, Dusich C, Foss CA, Ravert HT, Dannals RF, Seidel J, Prideaux A, Fox J, Sgouros G, Kozikowski AP, Pomper, MG. 2008. Synthesis and in-vivo evaluation of N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl[L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Clin. Cancer Res. 14:3036-3043.

Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y-J, Fox JJ, Hilton J, Lupold S, Kozikowski AP, and Pomper MG. 2008. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J. Med. Chem. 51:4504-4517.

Barinka C, Dusich CD, Ray S, Chen Y, Byun Y, Mease RC, Pomper MG, Lubkowski J. 2008. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: Structural characterizations. J. Med. Chem. 51:7737-7743.

Chandran SS, Banerjee SR, Mease RC, Pomper MG, and Denmeade SR. 2008. Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA). Cancer Biology & Therapy 7:974-982.



Chen T, Foss CA, Byun Y, Nimmagadda S, Pullambhatla M, Fox JJ, Castanares M, Lupold SE, Babich JW, Mease RC, Pomper, MG. 2008. Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer. J. Med. Chem. 51:7933-7943.

Foss CA, Mease RC, Fan H, Wang Y, Ravert HT, Dannals RF, Oleszewski RT, Heston WD, Kozikowski AP, and Pomper MG: 2005. Radiolabeled small molecule ligands for prostate-specific membrane antigen: In vivo imaging in experimental models of prostate cancer. Clin. Cancer. Res. 11:4022-4028.

Toretsky J, Levenson A, Weinberg IN, Tait JF, and Mease RC. 2004. Preparation of F-18 labeled annexin V: a potential PET radiopharmaceutical for imaging cell death. Nucl Med Biol 31:747-752 (2004).








 

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