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Gregory Kirk, M.D., Ph.D., M.P.H.

Associate Professor
410.502.2038 (p)
Gregory Kirk, M.D., Ph.D., M.P.H.
Interests

Epidemiology Johns Hopkins Bloomberg School of Public Health

Research Summary

My research focuses on understanding the natural history of viral infections, particularly HIV and the hepatitis viruses, in both domestic and international settings. The ALIVE (AIDS Linked to the Intravenous Experience) study is a long-standing and productive cohort that characterizes the natural history of HIV infection among intravenous drug users in Baltimore, MD. Our research in ALIVE ranges from pathogenesis to clinical to behavioral. In particular, I focus on the non-AIDS outcomes of HIV including cancer, liver and lung diseases. I also work on related topics with international collaborators, primarily in Africa. The interaction of viral, environmental and genetic factors is an important determinant in progression of many viral diseases. My research employs genetic, proteomic, and other novel laboratory and imaging methods to help understand and identify individuals at greatest risk for clinically relevant outcomes from HIV, HBV and HCV infections. The long-term goal of this research is to translate these markers into targeted interventions to help reduce the burden from these infections.

 

Journal Citations

Kirk, G.D.; Merlo, C.; P, O.D.; Mehta, S.H.; Galai, N.; Vlahov, D.; Samet, J.; Engels, E.A. HIV infection is associated with an increased risk for lung cancer, independent of smoking. Clin Infect Dis. 2007 Jul 1;45(1):103-110.
Balagopal, A.; Philp, F.H.; Astemborski, J.; Block, T.M.; Mehta, A.; Long, R.; Kirk, G.D.; Mehta, S.H.; Cox, A.L.; Thomas, D.L.; Ray, S.C. Human immunodeficiency virus-related microbial translocation and progression of hepatitis C. Gastroenterology. 2008 Jul;135(1):226-233.
Phelan, D.F.; Gange, S.J.; Ahdieh-Grant, L.; Mehta, S.H.; Kirk, G.D.; Shah, K.; Gravitt, P. Determinants of Newly Detected Human Papillomavirus Infection in HIV-Infected and HIV-Uninfected Injection Drug Using Women. Sexually transmitted diseases. 2009 Feb 9.
Althoff, K.N.; Gange, S.J.; Klein, M.B.; Brooks, J.T.; Hogg, R.S.; Bosch, R.J.; Horberg, M.A.; Saag, M.S.; Kitahata, M.M.; Justice, A.C.; Gebo, K.A.; Eron, J.J.; Rourke, S.B.; Gill, M.J.; Rodriguez, B.; Sterling, T.R.; Calzavara, L.M.; Deeks, S.G.; Martin, J.N.; Rachlis, A.R.; Napravnik, S.; Jacobson, L.P.; Kirk, G.D.; Collier, A.C.; Benson, C.A.; Silverberg, M.J.; Kushel, M.; Goedert, J.J.; McKaig, R.G.; Van Rompaey, S.E.; Zhang, J.; Moore, R.D. Late presentation for human immunodeficiency virus care in the United States and Canada. Clin Infect Dis. 2010 Jun 1;50(11):1512-1520.
Althoff, K.N.; Gebo, K.A.; Gange, S.J.; Klein, M.B.; Brooks, J.T.; Hogg, R.S.; Bosch, R.J.; Horberg, M.A.; Saag, M.S.; Kitahata, M.M.; Eron, J.J.; Napravnik, S.; Rourke, S.B.; Gill, M.J.; Rodriguez, B.; Sterling, T.R.; Deeks, S.G.; Martin, J.N.; Jacobson, L.P.; Kirk, G.D.; Collier, A.C.; Benson, C.A.; Silverberg, M.J.; Goedert, J.J.; McKaig, R.G.; Thorne, J.; Rachlis, A.; Moore, R.D.; Justice, A.C. CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation? AIDS Res Ther. 2010 Dec 15;7(1):45.
Drummond, M.B.; Kirk, G.D.; Ricketts, E.P.; McCormack, M.C.; Hague, J.C.; McDyer, J.F.; Mehta, S.H.; Engels, E.A.; Wise, R.A.; Merlo, C.A. Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIV. BMC Pulm Med. 2010;10:27.
Fwu, C.W.; Chien, Y.C.; Nelson, K.E.; Kirk, G.D.; You, S.L.; Kuo, H.S.; Feinleib, M.; Chen, C.J. Mortality after chronic hepatitis B virus infection: a linkage study involving 2 million parous women from Taiwan. J Infect Dis. 2010 Apr 1;201(7):1016-1023.
Gravitt, P.E.; Kirk, G.D. Progress and pitfalls in defining the influence of highly active antiretroviral therapy on human papillomavirus-associated cervical disease. J Infect Dis. 2010 Mar;201(5):650-652.
Hendrickson, S.L.; Lautenberger, J.A.; Chinn, L.W.; Malasky, M.; Sezgin, E.; Kingsley, L.A.; Goedert, J.J.; Kirk, G.D.; Gomperts, E.D.; Buchbinder, S.P.; Troyer, J.L.; O'Brien, S.J. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. PLoS One. 2010;5(9):e12862.
Herbeck, J.T.; Gottlieb, G.S.; Winkler, C.A.; Nelson, G.W.; An, P.; Maust, B.S.; Wong, K.G.; Troyer, J.L.; Goedert, J.J.; Kessing, B.D.; Detels, R.; Wolinsky, S.M.; Martinson, J.; Buchbinder, S.; Kirk, G.D.; Jacobson, L.P.; Margolick, J.B.; Kaslow, R.A.; O'Brien, S.J.; Mullins, J.I. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. J Infect Dis. 2010 Feb 15;201(4):618-626.
Kucirka, L.M.; Farzadegan, H.; Feld, J.J.; Mehta, S.H.; Winters, M.; Glenn, J.S.; Kirk, G.D.; Segev, D.L.; Nelson, K.E.; Marks, M.; Heller, T.; Golub, E.T. Prevalence, correlates, and viral dynamics of hepatitis delta among injection drug users. J Infect Dis. 2010 Sep 15;202(6):845-852.
Martin, M.P.; Qi, Y.; Goedert, J.J.; Hussain, S.K.; Kirk, G.D.; Hoots, W.K.; Buchbinder, S.; Carrington, M.; Thio, C.L. IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection. J Infect Dis. 2010 Dec 1;202(11):1749-1753.
Mehta, S.H.; Kirk, G.D.; Astemborski, J.; Galai, N.; Celentano, D.D. Temporal trends in highly active antiretroviral therapy initiation among injection drug users in Baltimore, Maryland, 1996-2008. Clin Infect Dis. 2010 Jun 15;50(12):1664-1671.
Mendy, M.E.; Welzel, T.; Lesi, O.A.; Hainaut, P.; Hall, A.J.; Kuniholm, M.H.; McConkey, S.; Goedert, J.J.; Kaye, S.; Rowland-Jones, S.; Whittle, H.; Kirk, G.D. Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa. J Viral Hepat. 2010 Feb 1;17(2):115-122.
Mosbruger, T.L.; Duggal, P.; Goedert, J.J.; Kirk, G.D.; Hoots, W.K.; Tobler, L.H.; Busch, M.; Peters, M.G.; Rosen, H.R.; Thomas, D.L.; Thio, C.L. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 2010 May 1;201(9):1371-1380.
Nandi, A.; Glass, T.A.; Cole, S.R.; Chu, H.; Galea, S.; Celentano, D.D.; Kirk, G.D.; Vlahov, D.; Latimer, W.W.; Mehta, S.H. Neighborhood poverty and injection cessation in a sample of injection drug users. Am J Epidemiol. 2010 Feb 15;171(4):391-398.
Sander, P.M.; Cole, S.R.; Ostrow, D.G.; Mehta, S.H.; Kirk, G.D. Determinants of alcohol consumption in HIV-uninfected injection drug users. Drug Alcohol Depend. 2010 Sep 1;111(1-2):173-176.
Shiels, M.S.; Cole, S.R.; Mehta, S.H.; Kirk, G.D. Lung cancer incidence and mortality among HIV-infected and HIV-uninfected injection drug users. J Acquir Immune Defic Syndr. 2010 Dec 1;55(4):510-515.
Yanik, E.L.; Lucas, G.M.; Vlahov, D.; Kirk, G.D.; Mehta, S.H. HIV and proteinuria in an injection drug user population. Clin J Am Soc Nephrol. 2010 Oct;5(10):1836-1843.
Marshall, M.M.; Kirk, G.D.; Caporaso, N.E.; McCormack, M.C.; Merlo, C.A.; Hague, J.C.; Mehta, S.H.; Engels, E.A. Tobacco use and nicotine dependence among HIV-infected and uninfected injection drug users. Addict Behav. 2011 Jan-Feb;36(1-2):61-67.

 

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