Pharmacology and Molecular Sciences
The continued widespread exposure of bacteria to antibiotics fosters the inevitable evolution of resistance mechanisms in clinically relevant pathogens, and the emergence of antibiotic resistance in bacteria that cause life-threatening infections has occurred at an alarming rate in almost every major class of antibiotics. The fight against rapid progression of clinical resistance to antibiotics demands the sustained discovery and development of new antibiotics and exploration of novel antibacterial targets. Our long term goal is to develop novel approaches to kill pathogenic bacteria with the ultimate objective of developing potential therapeutic agents. Our strategies for creating new antibacterial agents involve interdisciplinary research in the continuum of organic, biological and medicinal chemistry. Molecular biology, protein expression and biochemistry, and synthetic chemistry are key tools for our research.
Conway, M.J.; Alam, S.; Ryndock, E.J.; Cruz, L.; Christensen, N.D.; Roden, R.B.; Meyers, C. Tissue-spanning redox gradient-dependent assembly of native human papillomavirus type 16 virions. J Virol. 2009 Oct;83(20):10515-10526.
Lin, Z.; Yemelyanova, A.V.; Gambhira, R.; Jagu, S.; Meyers, C.; Kirnbauer, R.; Ronnett, B.M.; Gravitt, P.E.; Roden, R.B. Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2. Am J Pathol. 2009 Jan;174(1):136-143.