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Eric Frey

(443) 287-2426 (p)

Radiology and Radiological Sciences


Professor of Radiology Medical Physics Imaging

Research Summary

Dr. Frey’s laboratory develops new techniques for single and multiple isotope SPECT imaging and reconstruction for myocardial perfusion, brain neuroreceptor, and radioimmunotherapy treatment planning. He also has developed systems and algorithms for small animal microcomputed tomography using conventional and photon counting detectors.


Journal Citations

Du, Y.; Tsui, B.M.; Frey, E.C. Model-based compensation for quantitative 123I brain SPECT imaging. Phys Med Biol. 2006 Mar 7;51(5):1269-1282.

He, B.; Frey, E.C. Comparison of conventional, model-based quantitative planar, and quantitative SPECT image processing methods for organ activity estimation using In-111 agents. Phys Med Biol. 2006 Aug 21;51(16):3967-3981.

He, X.; Frey, E.C. Three-class ROC analysis--the equal error utility assumption and the optimality of three-class ROC surface using the ideal observer. IEEE Trans Med Imaging. 2006 Aug;25(8):979-986.

He, X.; Links, J.M.; Gilland, K.L.; Tsui, B.M.; Frey, E.C. Comparison of 180 degrees and 360 degrees acquisition for myocardial perfusion SPECT with compensation for attenuation, detector response, and scatter: Monte Carlo and mathematical observer results. J Nucl Cardiol. 2006 May-Jun;13(3):345-353.

He, X.; Metz, C.E.; Tsui, B.M.; Links, J.M.; Frey, E.C. Three-class ROC analysis--a decision theoretic approach under the ideal observer framework. IEEE Trans Med Imaging. 2006 May;25(5):571-581.

Song, H.; He, B.; Prideaux, A.; Du, Y.; Frey, E.; Kasecamp, W.; Ladenson, P.W.; Wahl, R.L.; Sgouros, G. Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases. J Nucl Med. 2006 Dec;47(12):1985-1994.

Xu, J.; Liu, C.; Wang, Y.C.; Frey, E.C.; Tsui, B.M. Attenuation correction for rotating multi-segment slant-hole SPECT in breast imaging. Phys Med. 2006;21 Suppl 1:44-47.

Du, Y.; Tsui, B.M.; Frey, E.C. Model-based crosstalk compensation for simultaneous 99mTc/123I dual-isotope brain SPECT imaging. Med Phys. 2007 Sep;34(9):3530-3543.

He, X.; Frey, E.C. An optimal three-class linear observer derived from decision theory. IEEE Trans Med Imaging. 2007 Jan;26(1):77-83.

Prideaux, A.R.; Song, H.; Hobbs, R.F.; He, B.; Frey, E.C.; Ladenson, P.W.; Wahl, R.L.; Sgouros, G. Three-dimensional radiobiologic dosimetry: application of radiobiologic modeling to patient-specific 3-dimensional imaging-based internal dosimetry. J Nucl Med. 2007 Jun;48(6):1008-1016.

Song, H.; Du, Y.; Sgouros, G.; Prideaux, A.; Frey, E.; Wahl, R.L. Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis. J Nucl Med. 2007 Jan;48(1):150-157.

He, B.; Wahl, R.L.; Du, Y.; Sgouros, G.; Jacene, H.; Flinn, I.; Frey, E.C. Comparison of residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--Monte Carlo simulation studies. IEEE Trans Med Imaging. 2008 Apr;27(4):521-530.

He, X.; Caffo, B.S.; Frey, E.C. Toward realistic and practical ideal observer (IO) estimation for the optimization of medical imaging systems. IEEE Trans Med Imaging. 2008 Oct;27(10):1535-1543.

He, X.; Frey, E.C. The meaning and use of the volume under a three-class ROC surface (VUS). IEEE Trans Med Imaging. 2008 May;27(5):577-588.

He, X.; Song, X.; Frey, E.C. Application of three-class ROC analysis to task-based image quality assessment of simultaneous dual-isotope myocardial perfusion SPECT (MPS). IEEE Trans Med Imaging. 2008 Nov;27(11):1556-1567.

Sgouros, G.; Frey, E.; Wahl, R.; He, B.; Prideaux, A.; Hobbs, R. Three-dimensional imaging-based radiobiological dosimetry. Seminars in nuclear medicine. 2008 Sep;38(5):321-334.

Du, Y.; Frey, E.C. Quantitative evaluation of simultaneous reconstruction with model-based crosstalk compensation for 99mTc/123I dual-isotope simultaneous acquisition brain SPECT. Med Phys. 2009 Jun;36(6):2021-2033.

He, B.; Du, Y.; Segars, W.P.; Wahl, R.L.; Sgouros, G.; Jacene, H.; Frey, E.C. Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and uptake. Med Phys. 2009 Feb;36(2):612-619.

He, B.; Wahl, R.L.; Sgouros, G.; Du, Y.; Jacene, H.; Kasecamp, W.R.; Flinn, I.; Hammes, R.J.; Bianco, J.; Kahl, B.; Frey, E.C. Comparison of organ residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--patient studies. Med Phys. 2009 May;36(5):1595-1601.

He, X.; Frey, E.C. The validity of three-class Hotelling trace (3-HT) in describing three-class task performance: comparison of three-class volume under ROC surface (VUS) and 3-HT. IEEE Trans Med Imaging. 2009 Feb;28(2):185-193.

Descourt, P.; Carlier, T.; Du, Y.; Song, X.; Buvat, I.; Frey, E.C.; Bardies, M.; Tsui, B.M.; Visvikis, D. Implementation of angular response function modeling in SPECT simulations with GATE. Phys Med Biol. 2010 May 7;55(9):N253-266.

He, B.; Frey, E.C. The impact of 3D volume of interest definition on accuracy and precision of activity estimation in quantitative SPECT and planar processing methods. Phys Med Biol. 2010 Jun 21;55(12):3535-3544.

He, B.; Frey, E.C. Effects of shortened acquisition time on accuracy and precision of quantitative estimates of organ activity. Med Phys. 2010 Apr;37(4):1807-1815.

He, X.; Cheng, L.; Fessler, J.A.; Frey, E.C. Regularized Image Reconstruction Algorithms for Dual-isotope Myocardial Perfusion SPECT (MPS) Imaging using a Cross-tracer Prior. IEEE Trans Med Imaging. 2010 Oct 14.

He, X.; Gallas, B.D.; Frey, E.C. Three-class ROC analysis--toward a general decision theoretic solution. IEEE Trans Med Imaging. 2010 Jan;29(1):206-215.

He, X.; Links, J.M.; Frey, E.C. An investigation of the trade-off between the count level and image quality in myocardial perfusion SPECT using simulated images: the effects of statistical noise and object variability on defect detectability. Phys Med Biol. 2010 Sep 7;55(17):4949-4961.

Hobbs, R.F.; Baechler, S.; Senthamizhchelvan, S.; Prideaux, A.R.; Esaias, C.E.; Reinhardt, M.; Frey, E.C.; Loeb, D.M.; Sgouros, G. A gamma camera count rate saturation correction method for whole-body planar imaging. Phys Med Biol. 2010 Feb 7;55(3):817-831.

Hobbs, R.F.; Baechler, S.; Wahl, R.L.; He, B.; Song, H.; Esaias, C.E.; Frey, E.C.; Jacene, H.; Sgouros, G. Arterial wall dosimetry for non-Hodgkin lymphoma patients treated with radioimmunotherapy. J Nucl Med. 2010 Mar;51(3):368-375.

Hobbs, R.F.; McNutt, T.; Baechler, S.; He, B.; Esaias, C.E.; Frey, E.C.; Loeb, D.M.; Wahl, R.L.; Shokek, O.; Sgouros, G. A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy. Int J Radiat Oncol Biol Phys. 2010 Oct 13.

Mok, G.S.; Du, Y.; Wang, Y.; Frey, E.C.; Tsui, B.M. Development and validation of a Monte Carlo simulation tool for multi-pinhole SPECT. Mol Imaging Biol. 2010 Jun;12(3):295-304.

Song, N.; He, B.; Frey, E.C. The effect of volume-of-interest misregistration on quantitative planar activity and dose estimation. Phys Med Biol. 2010 Sep 21;55(18):5483-5497.

Taguchi, K.; Frey, E.C.; Wang, X.; Iwanczyk, J.S.; Barber, W.C. An analytical model of the effects of pulse pileup on the energy spectrum recorded by energy resolved photon counting x-ray detectors. Med Phys. 2010 Aug;37(8):3957-3969.


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