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Dr. Mary Jo Fackler

Mary Jo Fackler

Biology and Regulation of Hematopoietic Stem Cell and CD34 Function


Assistant Professor of Oncology


Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD


Fellow, Oncology, The Johns Hopkins University School of Medicine

Research Summary

Dr. Fackler’s laboratory is interested in the biology and regulation of the hematopoietic progenitor/stem cell. She has focused her laboratory on studies of CD34 function. By studying models of CD34 overexpression, Dr. Fackler has found evidence that CD34 may play an important role in negatively regulating terminal differentiation of hematopoietic cells. Her laboratory is proceeding to identify the signal transduction mechanism of CD34 in cellular differentiation and adhesion.

Journal Citations

Felschow DM, McVeigh ML, Hoehn GT, Civin CI and Fackler MJ: The Adaptor Protein CrkL Associates With CD34. Blood 2001, In Press.


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