Mr. Fred Bunz
Associate Professor of Radiation Oncology and Molecular Radiation Sciences, and Oncology
M.D./Ph.D., Medical Scientist Training Program, Stony Brook University, New York
Ionizing radiation is a mainstay of therapy for most types of cancer. The DNA strand breaks, crosslinks, adducts and DNA replication intermediates that are caused by ionizing radiation and many other therapeutic agents trigger activation of a complex network of intracellular signaling molecules that ultimately control cell growth and cell death. Employing recently developed technologies, the Bunz laboratory studies the signaling molecules and pathways that are activated by DNA damage. The goal of this work is to better understand how current therapies work, and to develop new and improved cancer treatments.
Gallmeier, E.; Hucl, T.; Calhoun, E.S.; Cunningham, S.C.; Bunz, F.; Brody, J.R.; Kern, S.E. Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer. Cancer Biol Ther. 2007 May;6(5):654-660.
Hurley, P.J.; Bunz, F. ATM and ATR: components of an integrated circuit. Cell Cycle. 2007 Feb 1;6(4):414-417.
Hurley, P.J.; Wilsker, D.; Bunz, F. Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. Oncogene. 2007 Apr 19;26(18):2535-2542.
Rago, C.; Vogelstein, B.; Bunz, F. Genetic knockouts and knockins in human somatic cells. Nat Protoc. 2007;2(11):2734-2746.
Wilsker, D.; Bunz, F. Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival. Mol Cancer Ther. 2007 Apr;6(4):1406-1413.
Bunz, F. Thymidylate synthase and 5-fluorouracil: a cautionary tale. Cancer Biol Ther. 2008 Jul;7(7):995-996.
Horowitz, D.P.; Topaloglu, O.; Zhang, Y.; Bunz, F. Deficiency of bloom syndrome helicase activity is radiomimetic. Cancer Biol Ther. 2008 Nov 4;7(11).
Singh, A.; Boldin-Adamsky, S.; Thimmulappa, R.K.; Rath, S.K.; Ashush, H.; Coulter, J.; Blackford, A.; Goodman, S.N.; Bunz, F.; Watson, W.H.; Gabrielson, E.; Feinstein, E.; Biswal, S. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 2008 Oct 1;68(19):7975-7984.
Wilsker, D.; Petermann, E.; Helleday, T.; Bunz, F. Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20752-20757.
Bunz, F. Ancient drugs, modern targets. Cancer Biol Ther. 2009 Nov;8(21):2063-2064.
Sur, S.; Pagliarini, R.; Bunz, F.; Rago, C.; Diaz, L.A., Jr.; Kinzler, K.W.; Vogelstein, B.; Papadopoulos, N. A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc Natl Acad Sci U S A. 2009;106(10):3964-3969.
Wilsker, D.; Bunz, F. Chk1 phosphorylation during mitosis: a new role for a master regulator. Cell Cycle. 2009 Apr 15;8(8):1161-1163.
Chung, J.H.; Bunz, F. Cdk2 is required for p53-independent G2/M checkpoint control. PLoS Genet. 2010;6(2):e1000863.
Chung, J.H.; Zhang, Y.; Bunz, F. Checkpoint bypass and cell viability. Cell Cycle. 2010 Jun 22;9(11 ).
Singh, A.; Bodas, M.; Wakabayashi, N.; Bunz, F.; Biswal, S. Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal. 2010 Dec 1;13(11):1627-1637.
Sung, H.J.; Ma, W.; Wang, P.Y.; Hynes, J.; O'Riordan, T.C.; Combs, C.A.; McCoy, J.P., Jr.; Bunz, F.; Kang, J.G.; Hwang, P.M. Mitochondrial respiration protects against oxygen-associated DNA damage. Nat Commun. 2010 Apr 12;1(1):1-8