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Dr. Dmitri Artemov

Ph.D.
Interests

molecular imaging, imaging of drug delivery and drug resistance, imaging of endothelial progenitor cells and their role in tumor angiogenesis

Titles

Associate Professor of Radiology
Associate Professor of Oncology

Schools\Degrees

Ph.D., Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Training

Fellow, University of Wuerzburg, Germany

Fellow, Division of NMR Research, Department of Radiology, The Johns Hopkins University School of Medicine

Clinical Interests

Clinical imaging of drug uptake in tumors using 13C-labeled drugs

Research Summary

The major focus of my research is development of molecular imaging technology to monitor drug delivery to the tumor, drug release from tumor-targeted nanocarriers, and tumor response to therapy.

Journal Citations

Li, C.; Winnard, P.T., Jr.; Takagi, T.; Artemov, D.; Bhujwalla, Z.M. Multimodal image-guided enzyme/prodrug cancer therapy. J Am Chem Soc. 2006 Nov 29;128(47):15072-15073.

Pathak, A.P.; Artemov, D.; Neeman, M.; Bhujwalla, Z.M. Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype. Cancer Res. 2006 May 15;66(10):5151-5158.

Raman, V.; Artemov, D.; Pathak, A.P.; Winnard, P.T., Jr.; McNutt, S.; Yudina, A.; Bogdanov, A., Jr.; Bhujwalla, Z.M. Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res. 2006 Oct 15;66(20):9929-9936.
Ackerstaff, E.; Artemov, D.; Gillies, R.J.; Bhujwalla, Z.M. Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia. 2007 Dec;9(12):1138-1151.

Ackerstaff, E.; Gimi, B.; Artemov, D.; Bhujwalla, Z.M. Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line. Neoplasia. 2007 Mar;9(3):222-235.

Gimi, B.; Artemov, D.; Leong, T.; Gracias, D.H.; Bhujwalla, Z.M. MRI of regular-shaped cell-encapsulating polyhedral microcontainers. Magn Reson Med. 2007 Dec;58(6):1283-1287.

Gimi, B.; Artemov, D.; Leong, T.; Gracias, D.H.; Gilson, W.; Stuber, M.; Bhujwalla, Z.M. Cell viability and noninvasive in vivo MRI tracking of 3D cell encapsulating self-assembled microcontainers. Cell transplantation. 2007;16(4):403-408.

Kato, Y.; Okollie, B.; Raman, V.; Vesuna, F.; Zhao, M.; Baker, S.D.; Bhujwalla, Z.M.; Artemov, D. Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models. Cancer Biol Ther. 2007 Jun;6(6):891-897.

Raman, V.; Pathak, A.P.; Glunde, K.; Artemov, D.; Bhujwalla, Z.M. Magnetic resonance imaging and spectroscopy of transgenic models of cancer. NMR Biomed. 2007 May;20(3):186-199.

Vogel-Claussen, J.; Gimi, B.; Artemov, D.; Bhujwalla, Z.M. Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126. Cancer Biol Ther. 2007 Sep;6(9):1469-1475.

Zhu, W.; Okollie, B.; Artemov, D. Controlled Internalization of Her-2/neu Receptors by Cross-linking for Targeted Delivery. Cancer Biol Ther. 2007 Sep 4;6(12).

Glunde, K.; Shah, T.; Winnard, P.T., Jr.; Raman, V.; Takagi, T.; Vesuna, F.; Artemov, D.; Bhujwalla, Z.M. Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. Cancer Res. 2008 Jan 1;68(1):172-180.

Li, C.; Penet, M.F.; Winnard, P., Jr.; Artemov, D.; Bhujwalla, Z.M. Image-guided enzyme/prodrug cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Jan 15;14(2):515-522.

Li, C.; Wildes, F.; Winnard, P., Jr.; Artemov, D.; Penet, M.F.; Bhujwalla, Z.M. Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy. J Med Chem. 2008 Jun 26;51(12):3572-3582.

Zhu, W.; Okollie, B.; Bhujwalla, Z.M.; Artemov, D. PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach. Magn Reson Med. 2008 Apr;59(4):679-685.

Glunde, K.; Jacobs, M.A.; Pathak, A.P.; Artemov, D.; Bhujwalla, Z.M. Molecular and functional imaging of breast cancer. NMR Biomed. 2009 Jan;22(1):92-103.

Kato, Y.; Artemov, D. Monitoring of release of cargo from nanocarriers by MRI/MR spectroscopy (MRS): significance of T2/T2* effect of iron particles. Magn Reson Med. 2009 May;61(5):1059-1065.

Mikhaylova, M.; Stasinopoulos, I.; Kato, Y.; Artemov, D.; Bhujwalla, Z.M. Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA. Cancer Gene Ther. 2009 Mar;16(3):217-226.

Penet, M.F.; Pathak, A.P.; Raman, V.; Ballesteros, P.; Artemov, D.; Bhujwalla, Z.M. Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft. Cancer Res. 2009 Nov 15;69(22):8822-8829.

Glunde, K.; Artemov, D.; Penet, M.F.; Jacobs, M.A.; Bhujwalla, Z.M. Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. Chem Rev. 2010 May 12;110(5):3043-3059.

Kato, Y.; Holm, D.A.; Okollie, B.; Artemov, D. Noninvasive detection of temozolomide in brain tumor xenografts by magnetic resonance spectroscopy. Neuro Oncol. 2010 Jan;12(1):71-79.

Li, C.; Penet, M.F.; Wildes, F.; Takagi, T.; Chen, Z.; Winnard, P.T.; Artemov, D.; Bhujwalla, Z.M. Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy. ACS Nano. 2010 Nov 23;4(11):6707-6716.

Onuki, Y.; Jacobs, I.; Artemov, D.; Kato, Y. Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique. Biomaterials. 2010 Sep;31(27):7132-7138.

Shah, T.; Wildes, F.; Penet, M.F.; Winnard, P.T., Jr.; Glunde, K.; Artemov, D.; Ackerstaff, E.; Gimi, B.; Kakkad, S.; Raman, V.; Bhujwalla, Z.M. Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells. NMR Biomed. 2010 Jul;23(6):633-642.

Kato Y, Artemov D. "Monitoring of Release of Cargo From Nanocarriers by MRI/MR Spectroscopy (MRS): Significance of T2/T*2 Effect of Iron Particles", Magn Reson Med. 2009 May;61(5):1059-65. PMID: 19253373.

Mikhaylova M, Stasinopoulos I, Kato Y, Artemov D, Bhujwalla ZM. "Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA", Cancer Gene Ther. 2009 Mar;16(3):217-26. Epub 2008. PMID: 18927599.

3. Zhu W, Okkolie B, Artemov D, "Controlled Internalization of Her-2/neu Receptors by Cross-linking for Targeted Delivery", Cancer Biol Ther. 2007 Dec; 6(12), 1960-6. PMID: 18075296.

4. Raman V, Artemov D, Pathak AP, Winnard PT Jr, McNutt S, Yudina A, Bogdanov A, Bhujwalla ZM, "Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model", Cancer Res. 66(20): 9929-36, 2006. PMID: 17047055.

5. Artemov, D., Mori, N., Ravi, R., Bhujwalla Z.M. "MR Molecular Imaging of the HER-2/neu Receptor", Cancer Res, 63, 2723-27, 2003. PMID: 12782573.

6. Artemov, D., Bhujwalla, Z.M., Maxwell, RJ, Judson, I.R., Leach, M.O., Griffiths, J.R. and Glickson J.D. "Pharmacokinetics of the 13C labeled anticancer agent temozolomide detected in vivo by selective cross polarization transfer" Mag. Res.Med. 34, 338-342, 1995. PMID: 7500872.


7. Glunde K, Ackerstaff E, Natarajan K, Artemov D, Bhujwalla ZM. "Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin". Magn Reson Med. 2002 Nov;48(5):819-25. PMID: 12417996

8. Artemov, D., Mori, N., Okollie, B., Bhujwalla Z.M. "MR Molecular Imaging of the HER-2/neu Receptor in Breast Cancer Cells using targeted Iron Oxide Nanoparticles", Magn Reson Med, 49, 403-409, 2003. PMID: 12594741.

9. Kato Y, Okollie B, Artemov D, "Non-invasive 1H/13C magnetic resonance spectroscopic imaging of theintratumoral distribution of temozolomide" Magn Reson Med 55(4), 755-761, 2006. PMID: 16508914.

10. Kato Y, Okollie B, Raman V, Vesuna F, Zhao M, Baker SD, Bhujwalla Z, and Artemov D. "Contributing Factors of Temozolomide Resistance in MCF-7 Tumor Xenograft Models" Cancer Biology & Therapy, 6(6), 891-7, 2007. PMID: 17582214.

11. Vogel-Claussen J, Gimi B, Artemov D, Bhujwalla ZM. "Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126." Cancer Biol Ther. 2007 Sep;6(9):1469-75. Epub 2007 Jun 27. PMID: 17881899.

12. Zhu W, Okkolie B, Bhujwalla ZM, Artemov D, "PAMAM dendrimer based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach", Magn Reson Med. 2008 Apr; 59(4):679-85. PMID: 18302223,

13. Li C, Penet MF, Winnard P Jr, Artemov D, and Bhujwalla ZM. "Image-guided enzyme/prodrug cancer therapy", Clin Cancer Res, 14(2), 515-22, 2008 (Front Cover). PMID: 18223227.

14. Penet MF, Pathak AP, Raman V, Ballesteros P, Artemov D, Bhujwalla ZM. "Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft." Cancer Res. 2009 Nov 15;69(22):8822-9. Epub 2009 Oct 27. PMID: 19861534.

15. Kato Y, Holm DA, Okollie B, Artemov D*. "Noninvasive Detection of Temozolomide in Brain Tumor Xenograft by Magnetic Resonance Spectroscopy", J NeuroOncology, 12(1): 71-79, 2010.

 

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