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Dr. Jinyuan Zhou, Ph.D.

Assistant Professor

Radiology and Radiological Sciences


Affiliated Faculty
F.M. Kirby Research Center for Functional Brain Imaging
Assistant Professor
Department of Radiology, Johns Hopkins University School of Medicine


Fellowship, In Vivo MRI, 1997 - 1999
Department of Radiology, Johns Hopkins University School of Medicine
PhD, Physics, 1996
National Laboratory of Magnetic Resonance and Atomic and Molecular Physics
Wuhan Institute of Physics, The Chinese Academy of Sciences
BS, Physics, 1983
Fujian Normal University, China

Research Summary

Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and MRS to study brain function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, tissue protein MR imaging, and high-resolution diffusion tensor imaging (DTI). A major part of his current research is in vivo imaging of experimental brain tumor models and clinical imaging of brain tumor patients using a new MRI technique, the amide proton transfer (APT) imaging. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcomes.

Journal Citations

Jones, C.K.; Schlosser, M.J.; van Zijl, P.C.; Pomper, M.G.; Golay, X.; Zhou, J. Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med. 2006 Sep;56(3):585-592.
Byrne, S.T.; Gu, P.; Zhou, J.; Denkin, S.M.; Chong, C.; Sullivan, D.; Liu, J.O.; Zhang, Y. Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2007 Dec;51(12):4495-4497.
Zhang, J.; van Zijl, P.C.; Laterra, J.; Salhotra, A.; Lal, B.; Mori, S.; Zhou, J. Unique patterns of diffusion directionality in rat brain tumors revealed by high-resolution diffusion tensor MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2007 Sep;58(3):454-462.
Donahue, M.J.; Blakeley, J.O.; Zhou, J.; Pomper, M.G.; Laterra, J.; van Zijl, P.C. Evaluation of human brain tumor heterogeneity using multiple T1-based MRI signal weighting approaches. Magn Reson Med. 2008 Feb;59(2):336-344.
Ford, E.; Purger, D.; Tryggestad, E.; McNutt, T.; Christodouleas, J.; Rigamonti, D.; Shokek, O.; Won, S.; Zhou, J.; Lim, M.; Wong, J.; Kleinberg, L. A virtual frame system for stereotactic radiosurgery planning. International journal of radiation oncology, biology, physics. 2008 Nov 15;72(4):1244-1249.
Fox, J.; Ford, E.; Redmond, K.; Zhou, J.; Wong, J.; Song, D.Y. Quantification of Tumor Volume Changes During Radiotherapy for Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2008 Nov 25.
Salhotra, A.; Lal, B.; Laterra, J.; Sun, P.Z.; van Zijl, P.C.; Zhou, J. Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts. NMR in biomedicine. 2008 Oct 10;21:489-497.
Tao, S.C.; Li, Y.; Zhou, J.; Qian, J.; Schnaar, R.L.; Zhang, Y.; Goldstein, I.J.; Zhu, H.; Schneck, J.P. Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers. Glycobiology. 2008 Oct;18(10):761-769.
Zhao, J.M.; Har-el, Y.E.; McMahon, M.T.; Zhou, J.; Sherry, A.D.; Sgouros, G.; Bulte, J.W.; van Zijl, P.C. Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes. J Am Chem Soc. 2008 Apr 16;130(15):5178-5184.
Zhou, J.; Blakeley, J.O.; Hua, J.; Kim, M.; Laterra, J.; Pomper, M.G.; van Zijl, P.C. Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2008 Oct;60(4):842-849.
Zhou, J.; Trock, B.; Tsangaris, T.N.; Friedman, N.B.; Shapiro, D.; Brotzman, M.; Chan-Li, Y.; Chan, D.W.; Li, J. A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patient. Breast Cancer Res Treat. 2009 Nov 10.
Zhu, H.; Jones, C.K.; van Zijl, P.C.; Barker, P.B.; Zhou, J. Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain. Magn Reson Med. 2010 Sep;64(3):638-644.
Zhou, J. Amide proton transfer imaging of the human brain. Methods Mol Biol. 2011;711:227-237.
Zhou, J.; Tryggestad, E.; Wen, Z.; Lal, B.; Zhou, T.; Grossman, R.; Wang, S.; Yan, K.; Fu, D.X.; Ford, E.; Tyler, B.; Blakeley, J.; Laterra, J.; van Zijl, P.C. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med. 2011 Jan;17(1):130-134.


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