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George Sgouros, Ph.D.


Radiology and Radiological Sciences



Journal Citations

Jaggi, J.S.; Seshan, S.V.; McDevitt, M.R.; Sgouros, G.; Hyjek, E.; Scheinberg, D.A. Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1503-1512.
Sgouros, G.; Song, H.; Ladenson, P.W.; Wahl, R.L. Lung toxicity in radioiodine therapy of thyroid carcinoma: development of a dose-rate method and dosimetric implications of the 80-mCi rule. J Nucl Med. 2006 Dec;47(12):1977-1984.
Song, H.; He, B.; Prideaux, A.; Du, Y.; Frey, E.; Kasecamp, W.; Ladenson, P.W.; Wahl, R.L.; Sgouros, G. Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases. J Nucl Med. 2006 Dec;47(12):1985-1994.
Prideaux, A.R.; Song, H.; Hobbs, R.F.; He, B.; Frey, E.C.; Ladenson, P.W.; Wahl, R.L.; Sgouros, G. Three-dimensional radiobiologic dosimetry: application of radiobiologic modeling to patient-specific 3-dimensional imaging-based internal dosimetry. J Nucl Med. 2007 Jun;48(6):1008-1016.
Sgouros, G. Toward patient-friendly cell-level dosimetry. J Nucl Med. 2007 Apr;48(4):496-497.
Sofou, S.; Kappel, B.J.; Jaggi, J.S.; McDevitt, M.R.; Scheinberg, D.A.; Sgouros, G. Enhanced retention of the alpha-particle-emitting daughters of Actinium-225 by liposome carriers. Bioconjug Chem. 2007 Nov-Dec;18(6):2061-2067.
Song, H.; Du, Y.; Sgouros, G.; Prideaux, A.; Frey, E.; Wahl, R.L. Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis. J Nucl Med. 2007 Jan;48(1):150-157.
Baechler, S.; Hobbs, R.F.; Prideaux, A.R.; Recordon, M.; Bischof-Delaloye, A.; Sgouros, G. Estimates of radiation-absorbed dose to kidneys in patients treated with 90Y-ibritumomab tiuxetan. Cancer Biother Radiopharm. 2008 Oct;23(5):633-639.
Fu, D.-X.; Tanhehco, Y.; Chen, J.; Foss, C.A.; Fox, J.J.; Chong, J.-M.; Hobbs, R.F.; Fukayama, M.; Sgouros, G.; Kowalski, J.; Pomper, M.G.; Ambinder, R.F. Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors. Nat Med (N Y, NY, U S). 2008;14(10):1118-1122.
He, B.; Wahl, R.L.; Du, Y.; Sgouros, G.; Jacene, H.; Flinn, I.; Frey, E.C. Comparison of residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--Monte Carlo simulation studies. IEEE Trans Med Imaging. 2008 Apr;27(4):521-530.
Kim, P.S.; Armstrong, T.D.; Song, H.; Wolpoe, M.E.; Weiss, V.; Manning, E.A.; Huang, L.Q.; Murata, S.; Sgouros, G.; Emens, L.A.; Reilly, R.T.; Jaffee, E.M. Antibody association with HER-2/neu-targeted vaccine enhances CD8 T cell responses in mice through Fc-mediated activation of DCs. J Clin Invest. 2008 May;118(5):1700-1711.
Mease, R.C.; Dusich, C.L.; Foss, C.A.; Ravert, H.T.; Dannals, R.F.; Seidel, J.; Prideaux, A.; Fox, J.J.; Sgouros, G.; Kozikowski, A.P.; Pomper, M.G. N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Clin Cancer Res. 2008 May 15;14(10):3036-3043.
Sgouros, G. Update: molecular radiotherapy: survey and current status. Cancer Biother Radiopharm. 2008 Oct;23(5):531-540.
Sgouros, G. Alpha-particles for targeted therapy. Adv Drug Deliv Rev. 2008 Sep;60(12):1402-1406.
Sgouros, G.; Frey, E.; Wahl, R.; He, B.; Prideaux, A.; Hobbs, R. Three-dimensional imaging-based radiobiological dosimetry. Seminars in nuclear medicine. 2008 Sep;38(5):321-334.
Sgouros, G.; Song, H. Cancer stem cell targeting using the alpha-particle emitter, 213Bi: mathematical modeling and feasibility analysis. Cancer Biother Radiopharm. 2008 Feb;23(1):74-81.
Sofou, S.; Sgouros, G. Antibody-targeted liposomes in cancer therapy and imaging. Expert Opin Drug Deliv. 2008 Feb;5(2):189-204.
Song, H.; Shahverdi, K.; Huso, D.L.; Esaias, C.; Fox, J.; Liedy, A.; Zhang, Z.; Reilly, R.T.; Apostolidis, C.; Morgenstern, A.; Sgouros, G. 213Bi (alpha-emitter)-antibody targeting of breast cancer metastases in the neu-N transgenic mouse model. Cancer Res. 2008 May 15;68(10):3873-3880.
Song, H.; Shahverdi, K.; Huso, D.L.; Wang, Y.; Fox, J.J.; Hobbs, R.F.; Gimi, B.; Gabrielson, K.L.; Pomper, M.G.; Tsui, B.M.; Bhujwalla, Z.; Reilly, R.T.; Sgouros, G. An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer. Clin Cancer Res. 2008 Oct 1;14(19):6116-6124.
Wessels, B.W.; Konijnenberg, M.W.; Dale, R.G.; Breitz, H.B.; Cremonesi, M.; Meredith, R.F.; Green, A.J.; Bouchet, L.G.; Brill, A.B.; Bolch, W.E.; Sgouros, G.; Thomas, S.R. MIRD pamphlet No. 20: the effect of model assumptions on kidney dosimetry and response--implications for radionuclide therapy. J Nucl Med. 2008 Nov;49(11):1884-1899.
Zhao, J.M.; Har-el, Y.E.; McMahon, M.T.; Zhou, J.; Sherry, A.D.; Sgouros, G.; Bulte, J.W.; van Zijl, P.C. Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes. J Am Chem Soc. 2008 Apr 16;130(15):5178-5184.
Bolch, W.E.; Eckerman, K.F.; Sgouros, G.; Thomas, S.R. MIRD pamphlet No. 21: a generalized schema for radiopharmaceutical dosimetry--standardization of nomenclature. J Nucl Med. 2009 Mar;50(3):477-484.
He, B.; Du, Y.; Segars, W.P.; Wahl, R.L.; Sgouros, G.; Jacene, H.; Frey, E.C. Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and uptake. Med Phys. 2009 Feb;36(2):612-619.
He, B.; Wahl, R.L.; Sgouros, G.; Du, Y.; Jacene, H.; Kasecamp, W.R.; Flinn, I.; Hammes, R.J.; Bianco, J.; Kahl, B.; Frey, E.C. Comparison of organ residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--patient studies. Med Phys. 2009 May;36(5):1595-1601.
Hobbs, R.F.; Wahl, R.L.; Lodge, M.A.; Javadi, M.S.; Cho, S.Y.; Chien, D.T.; Ewertz, M.E.; Esaias, C.E.; Ladenson, P.W.; Sgouros, G. 124I PET-based 3D-RD dosimetry for a pediatric thyroid cancer patient: real-time treatment planning and methodologic comparison. J Nucl Med. 2009 Nov;50(11):1844-1847.
Loeb, D.M.; Garrett-Mayer, E.; Hobbs, R.F.; Prideaux, A.R.; Sgouros, G.; Shokek, O.; Wharam, M.D., Jr.; Scott, T.; Schwartz, C.L. Dose-finding study of 153Sm-EDTMP in patients with poor-prognosis osteosarcoma. Cancer. 2009 Jun 1;115(11):2514-2522.
Sgouros, G. From the Medical Internal Radiation Dose Committee. J Nucl Med. 2009 Feb;50(2):25N-26N.
Song, H.; Hobbs, R.F.; Vajravelu, R.; Huso, D.L.; Esaias, C.; Apostolidis, C.; Morgenstern, A.; Sgouros, G. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y. Cancer Res. 2009 Dec 1;69(23):8941-8948.
Baechler, S.; Hobbs, R.F.; Jacene, H.A.; Bochud, F.O.; Wahl, R.L.; Sgouros, G. Predicting hematologic toxicity in patients undergoing radioimmunotherapy with 90Y-ibritumomab tiuxetan or 131I-tositumomab. J Nucl Med. 2010 Dec;51(12):1878-1884.
Dieudonne, A.; Hobbs, R.F.; Bolch, W.E.; Sgouros, G.; Gardin, I. Fine-resolution voxel S values for constructing absorbed dose distributions at variable voxel size. J Nucl Med. 2010 Oct;51(10):1600-1607.
Hobbs, R.F.; Baechler, S.; Senthamizhchelvan, S.; Prideaux, A.R.; Esaias, C.E.; Reinhardt, M.; Frey, E.C.; Loeb, D.M.; Sgouros, G. A gamma camera count rate saturation correction method for whole-body planar imaging. Phys Med Biol. 2010 Feb 7;55(3):817-831.
Hobbs, R.F.; Baechler, S.; Wahl, R.L.; He, B.; Song, H.; Esaias, C.E.; Frey, E.C.; Jacene, H.; Sgouros, G. Arterial wall dosimetry for non-Hodgkin lymphoma patients treated with radioimmunotherapy. J Nucl Med. 2010 Mar;51(3):368-375.
Hobbs, R.F.; McNutt, T.; Baechler, S.; He, B.; Esaias, C.E.; Frey, E.C.; Loeb, D.M.; Wahl, R.L.; Shokek, O.; Sgouros, G. A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy. Int J Radiat Oncol Biol Phys. 2010 Oct 13.
Howell, R.W.; Sgouros, G. Kassis receives Loevinger-Berman award. J Nucl Med. 2010 Dec;51(12):16N.
Jentzen, W.; Hobbs, R.F.; Stahl, A.; Knust, J.; Sgouros, G.; Bockisch, A. Pre-therapeutic (124)I PET(/CT) dosimetry confirms low average absorbed doses per administered (131)I activity to the salivary glands in radioiodine therapy of differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 2010 May;37(5):884-895.
Lingappa, M.; Song, H.; Thompson, S.; Bruchertseifer, F.; Morgenstern, A.; Sgouros, G. Immunoliposomal delivery of 213Bi for alpha-emitter targeting of metastatic breast cancer. Cancer Res. 2010 Sep 1;70(17):6815-6823.
Loeb, D.M.; Hobbs, R.F.; Okoli, A.; Chen, A.R.; Cho, S.; Srinivasan, S.; Sgouros, G.; Shokek, O.; Wharam, M.D., Jr.; Scott, T.; Schwartz, C.L. Tandem dosing of samarium-153 ethylenediamine tetramethylene phosphoric acid with stem cell support for patients with high-risk osteosarcoma. Cancer. 2010 Dec 1;116(23):5470-5478.
Rosenblat, T.L.; McDevitt, M.R.; Mulford, D.A.; Pandit-Taskar, N.; Divgi, C.R.; Panageas, K.S.; Heaney, M.L.; Chanel, S.; Morgenstern, A.; Sgouros, G.; Larson, S.M.; Scheinberg, D.A.; Jurcic, J.G. Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin Cancer Res. 2010 Nov 1;16(21):5303-5311.
Senthamizhchelvan, S.; Bravo, P.E.; Esaias, C.; Lodge, M.A.; Merrill, J.; Hobbs, R.F.; Sgouros, G.; Bengel, F.M. Human biodistribution and radiation dosimetry of 82Rb. J Nucl Med. 2010 Oct;51(10):1592-1599.
Sgouros, G.; Roeske, J.C.; McDevitt, M.R.; Palm, S.; Allen, B.J.; Fisher, D.R.; Brill, A.B.; Song, H.; Howell, R.W.; Akabani, G.; Bolch, W.E.; Meredith, R.F.; Wessels, B.W.; Zanzonico, P.B. MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy. J Nucl Med. 2010 Feb;51(2):311-328.
Sofou, S.; Enmon, R.; Palm, S.; Kappel, B.; Zanzonico, P.; McDevitt, M.R.; Scheinberg, D.A.; Sgouros, G. Large anti-HER2/neu liposomes for potential targeted intraperitoneal therapy of micrometastatic cancer. J Liposome Res. 2010 Dec;20(4):330-340.
Wessels, B.W.; Dale, R.G.; Cremonesi, M.; Meredith, R.F.; Green, A.J.; Brill, B.; Bolch, W.E.; Sgouros, G.; Thomas, S.R. Renal dosimetry. Cancer Biother Radiopharm. 2010 Oct;25(5):597-599.
Song, H.; Sgouros, G. Radioimmunotherapy of solid tumors: searching for the right target. Curr Drug Deliv. 2011 Jan 1;8(1):26-44.


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