Dr. Tian Wang
Assistant Professor of Gynecology and Obstetrics
Assistant Professor of Oncology
Ovarian carcinoma is one of the most deadly neoplastic diseases among women, however, little is known about the molecular etiology of this disease. Dr. Wang’s research team focuses in understanding the molecular genetic basis in the development of ovarian carcinomas and applying the molecular genetic findings to develop new cancer diagnostics and therapeutics. In order to elucidate the genetic alterations at both DNA sequence and copy number levels, over the past several years, Dr. Wang has developed approaches, including high throughput mutational detection and Digital Karotyping, a technology that permits the identification of copy number alterations in cancer on a genome-wide scale with high resolution.
Using both strategies, she has recently performed a comprehensive genetic analysis of ovararian carcinomas and has identified several novel potential oncogenes and tumor suppressor genes in ovarian carcinomas. For example, one of the genes, named Rsf-1, is “amplified” in the most aggressive type of ovarian cancer. Patients who have tumors containing amplification of the Rsf-1 gene have a shorter survival than those without such amplification. Abnormally high levels of Rsf-1 trigger cell proliferation and allow cells to grow without anchorage—two hallmarks of cancerous cells. Rsf-1 has been known to play a key role in remodeling chromatin structure, the scaffold inside the nucleus of a cell, and thus regulating the genes for cell growth. Currently, Dr. Wang’s research team is developing a genetic test based on Rsf-1 amplification to predict clinical outcome in ovarian cancer and novel therapeutic strategies to treat ovarian cancers addicted to Rsf-1 and other aberrant signaling pathways in ovarian carcinomas.
Duncan, C.G.; Leary, R.J.; Lin, J.C.; Cummins, J.; Di, C.; Schaefer, C.F.; Wang, T.L.; Riggins, G.J.; Edwards, J.; Bigner, D.; Kopelovich, L.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Yan, H. Identification of microbial DNA in human cancer. BMC Med Genomics. 2009;2:22.
Kuo, K.T.; Mao, T.L.; Jones, S.; Veras, E.; Ayhan, A.; Wang, T.L.; Glas, R.; Slamon, D.; Velculescu, V.E.; Kuman, R.J.; Shih Ie, M. Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am J Pathol. 2009 May;174(5):1597-1601.
Jinawath, N.; Vasoontara, C.; Jinawath, A.; Fang, X.; Zhao, K.; Yap, K.L.; Guo, T.; Lee, C.S.; Wang, W.; Balgley, B.M.; Davidson, B.; Wang, T.L.; Shih Ie, M. Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma. PLoS One. 2010;5(6):e11198.
Jones, S.; Wang, T.L.; Shih Ie, M.; Mao, T.L.; Nakayama, K.; Roden, R.; Glas, R.; Slamon, D.; Diaz, L.A., Jr.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Papadopoulos, N. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science. 2010 Oct 8;330(6001):228-231
Kuo, K.T.; Mao, T.L.; Chen, X.; Feng, Y.; Nakayama, K.; Wang, Y.; Glas, R.; Ma, M.J.; Kurman, R.J.; Shih Ie, M.; Wang, T.L. DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma. Clin Cancer Res. 2010 Apr 1;16(7):1997-2008.
Park, J.T.; Chen, X.; Trope, C.G.; Davidson, B.; Shih Ie, M.; Wang, T.L. Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Am J Pathol. 2010 Sep;177(3):1087-1094.
Sheu, J.J.; Guan, B.; Choi, J.H.; Lin, A.; Lee, C.H.; Hsiao, Y.T.; Wang, T.L.; Tsai, F.J.; Shih Ie, M. Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. J Biol Chem. 2010 Dec 3;285(49):38260-38269.
Shih Ie, M.; Chen, L.; Wang, C.C.; Gu, J.; Davidson, B.; Cope, L.; Kurman, R.J.; Xuan, J.; Wang, T.L. Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis. Am J Obstet Gynecol. 2010 Dec;203(6):584 e581-522.
Ueda, S.M.; Yap, K.L.; Davidson, B.; Tian, Y.; Murthy, V.; Wang, T.L.; Visvanathan, K.; Kuhajda, F.P.; Bristow, R.E.; Zhang, H.; Shih Ie, M. Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas. J Oncol. 2010;2010:285191.