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Sarcoma Clinical Trials

Johns Hopkins Kimmel Cancer Center investigators lead or participate in a number of clinical trials. Here is a sampling of ongoing trials related to sarcomas, in which our investigators are studying new drug treatments, new drug combinations and new techniques in the management of sarcomas. Search our clinical trials directory. Our experts also participate in clinical trials through the Radiation Therapy Oncology Group.

Following is a description of some of our current studies:

#J1162 - A phase I study determining the safety and tolerability of combination therapy with Pazopanib, a VEGFR/PDGFR/Raf inhibitor, and GSK1120212, a MEK inhibitor, in advanced solid tumors enriched with patients with advanced differentiated thyroid cancer, soft tissue sarcoma, and cholangiocarcinoma.

#J1274 - A Study of the Safety and Efficacy of the Combination of Gemcitabine and Docetaxel with MORAb-004 in Metastatic Soft Tissue Sarcoma.

#J1291 - A Randomized, Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination with Doxorubicin vs. Doxorubicin Alone in Subjects with Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma.

#J1322 - Combination of External Beam Radiotherapy with 153Sm-EDTMP to Treat High Risk Osteosarcoma.

#J08126 - A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Cross-Over, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung.

#J12106 - A phase II trial of partially HLA-mismatched (HLA-haploidentical) bone marrow transplantation for high-risk solid tumors.

#PAEWS1031 - A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma.

 

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