The Sidney Kimmel Comprehensive Cancer Center

xxx

The Johns Hopkins Head & Neck Cancer Center

Home > The Sidney Kimmel Comprehensive Cancer Center > Centers & Clinics > Head & Neck Cancer Center > Research & Clinical Trials

Clinical Trials for Head & Neck Cancer Patients

Clinical trials come from the discoveries made in basic science laboratories. By taking these investigations and discoveries, researchers and scientists can create new therapies and treatments. Below are the listings of our current clinical trials. If you feel one of the trials is right for you, please call the principle contact or go to www.clinicaltrials.gov for more information .

Newly Diagnosed, Locally Advanced

Trial #

Name of Clinical Trial

Principal Investigator

Research
Nurse

SPORE

J1247

HPV +

and

HPV -

Phase II Trial of tadalafil ( Cialis ® )
in patients with squamous cell carcinoma of the upper aerodigestive tract

Joseph
Califano, MD

410-955-
3157

Nancy
Tsottles

410-614-5483

SPORE

J11129

HPV+

Only

Phase I Trial of DNA vaccine
pNGVL4a-CRT/E7(detox) in combination with cyclophosphamide in HPV 16 associated head and neck cancer patients

Sara
Pai, MD

410-502-
9825

Jenny
Ahn

410-502-3474

J0988

HPV+

Only

Phase I / II Trial of radiation treatment
de-intensification in favorable squamous cell carcinoma of the oropharynx

(non-smokers)

Harry
Quon, MD

410-955-
6980

Kelly
Szajna

410-614-3950

J1266

HPV-

Only

Phase I/II Trial of afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV negative locally advanced stage III/IV1/IVb HNSCC

( 2 weeks of induction chemo )

Shanthi
Marur, MD

410-502-
3820

Nancy
Tsottles

410-614-5483

J08101

HPV +

and

HPV -

Phase I / II Trial of dasatinib, cetuximab and radiation with or without cisplatin in locally advanced squamous cell carcinoma

Christine
Chung, MD

410-502-
3820

Nancy
Tsottles

410-614-5483

J1203

HPV +

and

HPV -

Phase III randomized double-blind, placebo-controlled trial to evaluate the efficacy and safety of afatinib (BIBW 2992) as adjuvant therapy after chemo-radiotherapy in primary unresected patients with stage III, IVa, or IVb loco-regionally advanced HNSCC

Christine
Chung, MD

410-502-
0678

Nancy
Tsottles

410-614-5483

Recurrent and/or Metastatic

Trial #

Name of Clinical Trial

Principal Investigator

Research Nurse

E1305

1^st Line

Phase III randomized Trial of chemotherapy with or without bevacizumab in patients with recurrent or metastatic head and neck cancer