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Research and Clinical Trials

Clinical trials come from the discoveries made in basic science laboratories. By taking these investigations and discoveries, researchers and scientists can create new therapies and treatments. Below are the listings of our current clinical trials. If you feel one of the trials is right for you, please call the principle contact or go to www.clinicaltrials.gov for more information .

Newly Diagnosed, Locally Advanced

 Trial #

 

Name of Clinical Trial

Principal Investigator

Research
Nurse

 

SPORE

J1247

 

HPV +

and

HPV -

Phase II Trial of tadalafil ( Cialis ® )
in patients with squamous cell carcinoma of the upper aerodigestive tract

Joseph
Califano, MD

410-955-
3157

Nancy
Tsottles

410-614-5483

 

J0988

 

 

HPV+

Only

 

Phase I / II Trial of radiation treatment
de-intensification in favorable squamous cell carcinoma of the oropharynx

(non-smokers)

Harry
Quon, MD

410-955-
6980

Kelly
Szajna

410-614-3950

J1266

HPV-

Only

 

Phase I/II Trial of afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV negative locally advanced stage III/IV1/IVb HNSCC

( 2 weeks of induction chemo )


Christine
Chung, MD

410-502-0678

Nancy
Tsottles

410-614-5483

J1203

HPV +

and

HPV - Smokers

Phase III randomized double-blind, placebo-controlled trial to evaluate the efficacy and safety of afatinib (BIBW 2992) as adjuvant therapy after chemo-radiotherapy in primary unresected patients with stage III, IVa, or IVb loco-regionally advanced HNSCC

Christine
Chung, MD

410-502-
0678

 Nancy
Tsottles

410-614-5483

E3311HPV +Phase II randomized trial of Transoral Surgical Resection followed by low-dose or standard radiation with biomarker correlatives in ressectable P16+ locally advanced oropharynx cancer.Jeremy Richmon, MD
410-955-6420
 
ARCIN 6685 A Multicenter trial of FDG-PET/CT staging of head and neck cancer and its imipact on the NO neck surgical treatmentRathan Subramaniam, MD 


Recurrent and/or Metastatic

Trial #

 

Name of Clinical Trial

Principal Investigator

Research Nurse

ECOG E1305

1st Line

Phase III randomized Trial of chemotherapy with or without bevacizumab in patients with recurrent or metastatic head and neck cancer

Arlene
Forastiere, MD


410-955-
9818

 


 

J1264Amy LinePhase I Study to evaluate the safety, tolerability and pharmacokinetics of MED14736 in subjects with advanced solid tumorsJulie Braher, MDRuth Smith
410-502-7097
J13124Any LinePhase I, Multi-Center, Open-label study of IMGN289 administered intravenously in adult patients with EGFR-positive solid tumorsHyunseok Kang, MDRuth Smith
410-502-7097


HPV Epidemiology Study

Trial #

 

Name of Clinical Trial

Principal Investigator

Research Nurse

SPORE PROVE

 

Papillomavirus role in oral cancer viral etiologyAmber D'Souza, MD
Carol Fakhry, MD

Nicole Kluz
443-287-8754

 

Quality of Life Outcome Study

Trial #

Name of Clinical Trial

Principal Investigator

Research Nurse

TALCObservational study of swallowing function after treatment of advanced laryngeal cancer.Christine Gourin, MD
410-624-0609
 

 Detailed  descriptions of these trials are available at  www.clinicaltrials.gov

 

 

 

 

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