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Research and Clinical Trials

Clinical trials come from the discoveries made in basic science laboratories. By taking these investigations and discoveries, researchers and scientists can create new therapies and treatments. Below are the listings of our current clinical trials. If you feel one of the trials is right for you, please call the principle contact or go to www.clinicaltrials.gov for more information .

Newly Diagnosed, Locally Advanced

 Trial #

 

Name of Clinical Trial

Principal Investigator

Research
Nurse

 

SPORE

J1247

 

HPV +

and

HPV -

Phase II Trial of tadalafil ( Cialis ® )
in patients with squamous cell carcinoma of the upper aerodigestive tract

Joseph
Califano, MD

410-955-
3157

Nancy
Tsottles

410-614-5483

 

J0988

 

 

HPV+

Non-Smokers

 

Phase I / II Trial of radiation treatment
de-intensification in favorable squamous cell carcinoma of the oropharynx

Harry
Quon, MD

410-955-
6980

Kelly
Szajna

410-614-3950

J1203

HPV + and HPV Non-smokers

 

Randomized Phase III Trial (double-blind, placebo-controlled ) to evaluate the efficacy and safety of afatinib as adjuvant therapy after chemo-radiotherapy in primary unresected patients with stage III , IVa, or IVb advanced head and neck SCCa

Christine
Chung, MD

410-502-0678

Nancy
Tsottles

410-614-5483

E3311HPV +Phase II randomized trial of TransOral Surgical Resection followed by low-dose or standard radiation with biomarker correlatives in ressectable HPV+/P16+ locally advanced oropharynx cancer.Jeremy Richmon, MD
410-955-6420
Tracy Weikel
410-955-4044
RTOG
1216

 
HPV -Randomized Phase II/III Trial of surgery and post-operative radiation with concurrent cisplatin vs docetaxel vs docetaxel & cetuximab for high-risk SCCa of the head and neckChristine Chung, MD
410-502-0678
Nancy Tsottles
410-614-5483


Recurrent and/or Metastatic

Trial #

 

Name of Clinical Trial

Principal Investigator

Research Nurse

ECOG E1305

1st Line

Phase III randomized Trial of chemotherapy with or without bevacizumab in patients with recurrent or metastatic head and neck squamous cell cancer

Arlene
Forastiere, MD


410-955-
9818

 


 

J131771st LineRandomized, Double-blind, Placebo-Controlled study of chemotherapy plus cetuximab in combination with VTX-2337 in patients with recurrent or metastatic head and neck SCCaHyunseok Kang, MD
410-502-3820
Nancy Tsottles
410-614-5483
J13124Any LinePhase I, Multi-Center, Open-label study of IMGN289 administered intravenously in adult patients with EGFR-positive solid tumorsHyunseok Kang, MD
410-502-3820
Ruth Smith
410-502-7097


HPV Epidemiology Study

Trial #

 

Name of Clinical Trial

Principal Investigator

Research Nurse

 PROVE
J1366

 

Papillomavirus role in oral cancer viral etiology (PROVE)Amber D'Souza, MD
Carol Fakhry, MD

Nicole Kluz
443-287-8754

 

Quality of Life Outcome Study

Trial #

Name of Clinical Trial

Principal Investigator

Research Nurse

TALCObservational study of swallowing function after treatment of advanced laryngeal cancer. (TALC)Christine Gourin, MD
410-624-0609
 
 SmaRTA comprehensive Smoking Cessation Intervention during radiation therapy for upper aerodigestive cancers (SmaRT)Amber D'Souza, MD
Carol Fakhry, MD

Eleni Rettig, MD
860-377-9377

Biospecimen Collection Study

J13144A biospecimen collection study to determine EGFR inhibitor resistance in head and neck squamous cell cancerChristine Chung, MD
410-502-0678
Zubair Khan
410-955-3157

Imaging Studies

J13140Oropharynx anatomic imaging with ultrasoundCarol Fakhry, MD
ACRIN
6685
A Multicenter trial of FDG-PET/CT staging of head and neck cancer and its impact on the N0 neck surgical treatmentRathan Subramaniam, MD

Detailed  descriptions of these trials are available at  www.clinicaltrials.gov

 

 
 

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