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Depending on your type of brain tumor, your provider may recommend radiation, chemotherapy or both of these as part of your treatment. Radiation is delivered to the area of the brain where the tumor is or the area where it was before surgery. Chemotherapy, particularly Temador (temozolomide), reaches this same area by going through the blood stream and then into the brain. Many times, radiation and chemotherapy are combined for an additive effect and to produce better treatment results. Your treatment plan will be discussed with you in detail. The standard therapy for a glioblastoma multiforme (GBM, grade IV tumors) is outlined below. The same treatment is frequently prescribed for anaplastic (AA, grade III tumors) as well.
Standard treatment for glioblastoma multiforme ( and also many grade III tumors) is based on the Stupp Protocol published by the New England Journal of Medicine, 2005. This consists of:
Remember, this is the standard treatment outline. You may be participating in an experimental trial/study which may add other medications or modalities to your treatment plan. These trials/studies may also prolong the length of time you are taking a particular drug. If you are participating in such a trial/suday, this information will be explained to you during the discussion of the trial/study.
Temodar (Temozolomide) - Oral Chemotherapy
Avastin is approved for Glioblastoma (GBM) when taken alone in adult patients whose cancer has progressed after prior treatment. The effectiveness of Avastin in GBM is based on tumor response. Currently, no data have shown whether or not Avastin improves disease-related symptoms or survival in people previously treated for GMB. Avastin is a tumor-starving (or anti-angiogenic) therapy. The purpose of Avastin is to block a protein called vascular endothelial growth factor, or VEGF. Normal cells produce VEGF, but some cancer cells overproduce VEGF. Blocking VEGF may prevent the growth of new blood vessels that feed tumors.
Avastin is given as an infusion, meaning you recieve Avastin through a small needle in your vein or through a port. Because Avastin is given as an infusion, infusion reactions may occur. Avastin infustions will be stopped by your doctor or nurse if infusion reactions are severe.
Your doctor or nurse will monitor you for signs of an infusion reaction, which may include:
Possible serious side effects can occur. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if you have symptoms related to these side effects.
Please see full product information, including serious side effects for additional and important safety information.