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Clinical Trials

For more information, please email Beatriz Kohler regarding clinical trials: inr@jhmi.edu

SAMMPRIS Trial

Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis. SAMMPRIS is an NIH-funded, multi-center clinical trial. The purpose of the SAMMPRIS study is to compare the safety and effectiveness of either Intensive Medical Therapy PLUS Stenting or Intensive Medical Therapy alone to prevent stroke, heart attack or death in patients with narrowed brain blood vessels.     

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Familial Intracranial Aneurysm Study, FIA Study NIH

The Familial Intracranial Aneurysm Study, also known as the FIA study, is a collaborative research effort of neurologists and neurosurgeons throughout the United States, Canada, Australia, and New Zealand. These researchers are studying genetic and other risk factors which may be important in the development of intracranial aneurysms. This study is sponsored by the National Institutes of Health.    

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Interventional Management of Stroke, IMS III

The Interventional Management of Stroke (IMS III) Trial is a randomized, open-label multi-center study that will compare a combined intravenous (IV) and intra-arterial (IA) treatment approach to restoring blood flow to the brain to the current standard FDA approved treatment approach of giving IV rt-PA alteplase, Activase,® alone.

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