2013 Request for Applications
Request for applications for translational research pilot studies in Malaysia
Perdana University Graduate School of Medicine in collaboration with the Johns Hopkins School of Medicine (PUGSOM) is the first graduate entry medical school in Malaysia and is based on the Genes to Society curriculum developed at Johns Hopkins University School of Medicine (JHUSOM). PUGSOM is building a translational research program consistent with the Genes to Society paradigm.
PUGSOM faculty seek to develop a network of interdisciplinary research partners focusing on health problems important to Malaysia. To facilitate this development, the Johns Hopkins Swami Institute for International Medical Education (SIIME) invites Johns Hopkins University faculty members to submit proposals for funding pilot studies to support the growth and expansion of our Bioinformatics Initiative and Center for Clinical and Translational Research (CCTR). The mission of the Bioinformatics Initiative is to develop capacity to translate theoretical developments in computational biology and bioinformatics to interdisciplinary research programs, with a focus on high-dimensional data analysis. The mission of the CCTR is to develop a core faculty and staff with expertise on the design and implementation of clinical and population-based research studies in Malaysia. Proposals are limited to the following research areas:
- Breast, colorectal, and cervical cancer
- Emerging infections and pathogenesis (esp. dengue, malaria, tuberculosis, and HIV)
- Metabolic diseases (esp. type 2 diabetes)
Proposals must be developed in collaboration with the PUGSOM Bioinformatics Initiative and/or the CCTR. Proposals which include co-investigators from other research institutions in Malaysia are particularly encouraged. Applications should be targeted to filling important gaps in understanding the scientific problem in Malaysia, and include a collaborative development plan to expand the research in Malaysia beyond the pilot phase. Investigators with previous SIIME awards must include a progress report and a plan to include the PUGSOM Bioinformatics Initiative and/or CCTR in the next phase of funding. We anticipate that the budget for applications will be up to $150K/year. The grants are generally funded for 1 year, but may be funded for 2 years contingent on productivity and availability of funds. Principal investigator effort cannot be included on grants. Indirect costs will not be charged. Young investigators are encouraged to apply.
A panel of internal investigators will score the applications. The proposals will be judged on the basis of meeting a critical gap in research in Malaysia, scientific approach and innovation, and on the likelihood of developing successful collaboration with Malaysian investigators. Applications may use this mechanism to supplement existing projects if sufficient justification of the added value obtained by the proposed Malaysian collaboration is provided.
The format for proposals is as follows:
- A brief proposal, not to exceed four pages (excluding Appendix)
- If the grant is an extension of a 2012 SIIME award, include 1-page progress report.
- Proposal format:
- Scientific abstract
- Goal of the project
- Rationale (including the research gap in Malaysia)
- Pertinent experience and/or preliminary data
- The US-Malaysia scientific team and scientific leaders and involvement of Bioinformatics Initiative or CCTR: provide rationale for assembly of a US-Malaysian collaboration
- Anticipated pitfalls
- A 1-year budget, separating start-up and operating costs
- Anticipated milestones
- Appendix: NIH type biosketch of investigators, current other support (NIH format), any supplemental figures (maximum 2 pages)
Inquiries about the RFP or collaborative opportunities in Malaysia can be directed to Patti Gravitt, Vice Dean-Research, Perdana University Graduate School of Medicine.
The deadline for submission is June15, 2013
Visit http://www.perdanauniversity.edu.my/pugsom/ for further information on PUGSOM.
2012 Award Recipients
SIIME is pleased to announce it has awarded four competitive grant awards to JH faculty beginning July 1, 2012. SIIME received an overwhelming response to its request for proposals seeking to promote research projects between Johns Hopkins University School of Medicine and Malaysia. Awards were rated based primarily on scientific quality. Additional considerations included the significance of the scientific question to Malaysia, relevance of the project resources to the future of science in Malaysia, and the robustness of engagement with Malaysian colleagues.
The studies that will be funded are:
- “Endothelial Cell Barrier Responses to African trypanosomes and Dengue Virus Infection.” Dr. Dennis Grab, in collaboration with Dr. Devi, of the University of Malaya, will work to better understand African trypanosome and dengue virus interactions with endothelial cell barriers by using molecular profiling to determine the potential transcriptomic state of African trypanosome/dengue virus-infected endothelium under conditions of shear stress blood flow as it occurs in vivo. The knowledge gained will help design improved therapies to limit morbidity and sometimes fatal complications observed with these vector-borne diseases.
- “Microbial Associations with Colorectal Cancer in Malaysia” Drs. Elizabeth Wick and Cynthia Sears, in collaboration with Drs. Vadivelu, Cheah and Roslani, of the University of Malaya, will prospectively study the role of microbiome and enterotoxigenic Bacteroides fragilis (ETBF) or ETBF-like bacteria in colorectal cancer in Kuala Lumpur, Malaysia. Cancer is now the fourth leading cause of death in Malaysia, with the incidence of colorectal cancer increasing.
- “Molecular and metabolic distinctions between non-alcoholic fatty liver disease and Type 2 diabetes mellitus.” Dr. Mehboob Hussain, in collaboration with Dr. Asif Khan of Perdana University Graduate School of Medicine, and Drs. Goh and Chan, of the University of Malaya, will investigate the changes in hepatic gene expression and substrate flux in humans with non-alcoholic fatty liver disease with or without Type 2 diabetes mellitus.
- “Preventing Childhood Injuries in Malaysia: Piloting a home environment injury risk assessment and mitigation program” Dr. Abdulgafoor Bachani, in collaboration with Dr. Mani, of the Universiti Putra Malaysia, will address the knowledge gap regarding childhood injuries in home settings in Malaysia. This will be accomplished by developing and testing an injury hazard assessment module, an educational pamphlet and a home-based tutorial program.