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Federal regulations do not distinguish between self-experimentation and research on subjects who are recruited for a specific project. At JHM, faculty and staff members who wish to act as participants in their own research should consider themselves human subjects. The Institutions require submission of an application to the JHM IRB prior to enrollment in a project or initiation of an experiment. The JHM IRB is authorized to review and approve requests for self-experimentation. There are two reasons for the required JHM IRB review and approval: