One key to the success of any future cell-based therapy-successfully transplant and maintain cells in a patient-will require a better understanding of how the immune system develops and functions. Researchers in our Immunobiology program at ICE are keen to unravel the molecular mechanisms behind the human immune system as well as how stem cells differentiate into specialized immune cells. Using a combination of molecular, cellular and genomic biology techniques as well as mouse models, the Immunobiology labs strive to unravel the mysteries of how the immune system distinguishes between self and non-self and how that might be harnessed to improve transplantation therapies and treatments.
Using tiny particles designed to target cancer-fighting immune cells, Johns Hopkins researchers have trained the immune systems of mice to fight melanoma, a deadly skin cancer.
Key Found To Restoring 'Exhausted' HIV-Fighting Immune Cells
Researchers have identified a protein that causes loss of function in immune cells combatting HIV. The scientists report that the protein, Sprouty-2, is a promising target for future HIV drug development, since disabling it could help restore the cells' ability to combat the virus.
Football-Shaped Particles Bolster The Body's Defense Against Cancer
Researchers at have succeeded in making flattened, football-shaped artificial particles that impersonate immune cells, and can teach other immune cells to recognize and destroy cancer cells in mice.