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School of Medicine
Brain Cell ‘Executioner’ Identified
Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer’s. Researchers have pinpointed the protein at the end of that chain of events that delivers the fatal strike by carving up a cell’s DNA.
New Treatment Strategy Could Cut Parkinson’s Disease Off at the Pass
Researchers report they have identified a protein that enables a toxic natural aggregate to spread from cell to cell in a mammal’s brain — and a way to block that protein’s action.Their study suggests that an immunotherapy already in clinical trials as a cancer therapy should also be tested as a way to slow the progress of Parkinson’s disease.
MRI Guidance Shows Promise in Delivering Stem Cell Therapies
A team of scientists reports it has delivered stem cells to the brain with unprecedented precision by threading a catheter through an artery and infusing the cells under real-time MRI guidance. This new technique could be used to treat Parkinson’s disease, stroke, and other brain damaging disorders.
Gregg Semenza Wins Lasker Award for Insights into How Cells Sense Oxygen
Semenza is best known for his groundbreaking discovery of hypoxia-inducible factor 1, or HIF-1, the protein that switches genes on and off in cells in response to low oxygen levels.These findings could result in treatments for illnesses ranging from cancer to diabetes.
New Hope for Zika Treatment Found in Large-Scale Screen of Existing Drugs
Researchers join collaborative group to screen 6,000 existing drugs in hopes of finding treatments for Zika Virus infection. Scientists report that a specialized drug screen test using lab-grown human cells has revealed two classes of compounds already in the pharmaceutical arsenal that may work against mosquito-borne Zika virus infections.
Podcasts with ICE researchers
- Finding a Cure for Parkinson's Disease with Ted Dawson
- Scientists Convert Blood Cells Back to Embryonic Stem Cell-Like State with Elias Zambidis
- Transforming Skin Cells to Stem Cells with Ted Dawson
- What Anti-Depression Treatments Actually Target in the Brain with Hongjun Song
- Preventing Breast Cancer Spread with Gregg Semenza
- How the Zika Virus May Cause Microcephaly with Hongjun Song
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Stem cell research at Johns Hopkins Medicine
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