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The Institute for Cell Engineering (ICE) at Johns Hopkins

Neuroscientist Valina Dawson introduces the Institute for Cell Engineering (ICE), where researchers are working to solve problems such as transplant rejection, Parkinson's disease, and coronary artery disease using regenerative medicine.

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The Immunobiology Program at Johns Hopkins’ Institute for Cell Engineering

Stephen Desiderio introduces the Immunobiology Program, where scientists study how our immune system works and look for ways to bolster it.

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The Neuroregeneration Program at Johns Hopkins’ Institute for Cell Engineering

Researcher Valina Dawson introduces the Neuroregeneration Program, where scientists study causes and potential treatments for conditions such as Parkinson’s and stroke.

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The Stem Cell Biology Program at Johns Hopkins’ Institute for Cell Engineering

Researcher Hongjun Song introduces the Stem Cell Biology Program, where scientists get an up-close look at diseases by making stem cells with patients' DNA and growing affected cell types in the lab. Others are working on ways to make blood for transfusions or seeing how mental illness relates to problems in early brain development.

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The Vascular Biology Program at Johns Hopkins' Institute for Cell Engineering

Researcher Gregg Semenza introduces the Vascular Biology Program, where scientists trace cells as they move through the body and study the relationship between low-oxygen conditions, blood vessel growth, and cancer.

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#TomorrowsDiscoveries: Brain Cells Damaged by Stroke - Dr. Shaida Andrabi

#TomorrowsDiscoveries: After a stroke, brain cells lose their capacity to generate energy. Dr. Shaida Andrabi and his team are working to find out why this happens and how to prevent it.

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#TomorrowsDiscoveries: Neurons That Control Biological Rhythms and Sleep - Dr. Seth Blackshaw

#TomorrowsDiscoveries: The hypothalamus is a cherry-sized part of the brain that serves as the master regulator of many behaviors, including biological rhythms, sleeping and eating. Dr. Seth Blackshaw’s lab has identified genes that control the formation of neurons in the hypothalamus that control biological rhythms and sleep, paving the way for therapies for sleep disorders, obesity and diabetes.

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#TomorrowsDiscoveries: Using Nanoparticles to Reduce the Need for Biopsies - Dr. Jeff Bulte

#TomorrowsDiscoveries: When he was 7, Dr. Jeff Bulte discovered the beauty of cells when he received a microscope for Christmas. Today, he uses magnetic nanoparticles to make transplanted stem cells visible in patients, which could reduce the need for invasive biopsies.

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#TomorrowsDiscoveries: Treating Diseases by Understanding Cell Identity | Patrick Cahan, Ph.D.

#TomorrowsDiscoveries: Biomedical engineer Patrick Cahan studies the molecular basis of cell type identity. He is making a tool that measures how closely cells grown in a lab mimic those in our bodies, which could help pave the way to replacing damaged tissue and more effectively studying diseases in the lab. The tool will also help him detect how cancer rewires the normal circuitry of a cell.

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#TomorrowsDiscoveries: Improving Bone Marrow Transplants - Dr. Linzhao Cheng

#TomorrowsDiscoveries: Using engineered stem cells, Dr. Linzhao Cheng is working to develop improved methods for bone marrow transplants and blood transfusions. Recently, his group helped to overcome one of the greatest hurdles of stem cell therapies: how to produce large numbers of potent human stem cells.

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#TomorrowsDiscoveries: Keeping Memories Safe - Dr. Ted Dawson

#TomorrowsDiscoveries: Neurons store our memories and control all aspects of our bodily functions; they are what make us human. Dr. Ted Dawson’s research focuses on the culprits that kill neurons. His hope is to find ways to prevent the loss of neurons in Parkinson’s disease, stroke and other brain disorders.

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#TomorrowsDiscoveries: Using Human Neurons to Prevent Brain Injury - Dr. Valina Dawson

#TomorrowsDiscoveries: Millions of Americans suffer from brain injury because of stroke or diseases. Using lab-grown human neurons, Dr. Valina Dawson is working to identify what causes brain cell death. Her research may lead to new treatments to prevent brain injury.

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#TomorrowsDiscoveries: DNA Rearrangements That Cause Childhood Cancer - Dr. Stephen Desiderio

#TomorrowsDiscoveries: To battle invaders, our immune system deploys antibodies, made by shuffling bits of DNA. But if the DNA and developing immune cells are misshuffled, they can cause childhood cancer. Dr. Stephen Desiderio and his team study these DNA rearrangements, and they’ve discovered ways the immune system protects us from damage to our genes, gaining insight into the causes of leukemia.

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#TomorrowsDiscoveries: Monitoring Transplanted Stem Cell Fate - Dr. Assaf Gilad

#TomorrowsDiscoveries: While stem cells can be used to induce tissue repair, many of the cells will die immediately after they are transplanted. Dr. Assaf Gilad is developing new technologies to “tag” stem cells and monitor cell fate with MRI, improving patient safety and treatment outcomes, especially for those with brain cancer and heart disease.

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#TomorrowsDiscoveries: Stem Cell Delivery Under MRI - Dr. Miroslaw Janowski

#TomorrowsDiscoveries: Dr. Miroslaw Janowski worked with patients for many years, but he moved to research when he realized he wanted to be a part of the discoveries that help patients. Now he focuses on developing minimally invasive stem cell delivery under MRI to help patients with stroke, injury, epilepsy and many other disorders.

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#TomorrowsDiscoveries: Brain Cell Death in People with Parkinson’s Disease - Dr. Hanseok Ko

#TomorrowsDiscoveries: Using stem cells and mice, Dr. Han Seok Ko is working to understand why specialized brain cells die in people with Parkinson’s disease. By identifying a protein that can govern the process of a disease, Dr. Ko comes closer to finding new ways to treat and control the symptoms of Parkinson’s.

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#TomorrowsDiscoveries: ‘Glitch’ that Causes Mental Disorders - Dr. Guo-li Ming

#TomorrowsDiscoveries: When the brain is in the early developmental period, a “glitch” can lead to mental disorders, such as schizophrenia, autism, bipolar disorder and depression. Dr. Guo-li Ming studies the biology behind brain cells, with the hope of developing new strategies for treating patients and improving their quality of life.

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#TomorrowsDiscoveries: Understanding the Immune System— Dr. Joel Pomerantz

#TomorrowsDiscoveries: Better understanding white blood cells and the body’s immune response may help researchers detect and fight cancer. Dr. Joel Pomerantz and his team at Johns Hopkins study the immune system to this end.

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#TomorrowsDiscoveries: Giving Immune Response a Nano-Boost— Dr. Jonathan Schneck

#TomorrowsDiscoveries: Can a custom-built white blood cell avoid suppression by cancer and boost our immune system? Dr. Jonathan Schneck has developed “artificial antigen-presenting cells” and is working to put them to use in the clinic.

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#TomorrowsDiscoveries: Chemotherapy-Resistant Breast Cancer Stem Cells - Dr. Gregg Semenza

#TomorrowsDiscoveries: While chemotherapy attacks and kills 99 percent of breast cancer cells, it leaves behind chemotherapy-resistant cancer stem cells, which can later cause metastatic tumors. Dr. Gregg Semenza’s team has identified a way to overcome the resistance of cancer stem cells to chemotherapy, completely eradicating breast tumors in mice.

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#TomorrowsDiscoveries: How Stem Cells May Treat Brain Injuries - Dr. Hongjun Song

#TomorrowsDiscoveries: Our brains produce over 1,000 new nerve cells every day. Dr. Hongjun Song develops new technologies to study stem cells in humans and animals, in hopes of one day harnessing our own regeneration potential to improve learning and memory and to help treat brain injuries and disorders, such as epilepsy and depression.

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#TomorrowsDiscoveries: Using MRI to Repair Brain Damage - Dr. Piotr Walczak

#TomorrowsDiscoveries: Experiments have shown that stem cells are capable of repairing brain damage caused by diseases such as multiple sclerosis or stroke. Using noninvasive imaging, such as MRI, Dr. Piotr Walczak can monitor stem cell therapy to see where transplanted cells are, which may help in developing more effective therapies for patients.

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#TomorrowsDiscoveries: Using Stem Cells to Treat Blood Disorders - Dr. Elias Zambidis

#TomorrowsDiscoveries: Dr. Elias Zambidis cares for children suffering from leukemia and other blood disorders. His laboratory studies human pluripotent stem cells, which may one day be used to treat not only blood disorders, but also heart disease, vascular disease, cancer and autoimmune diseases.

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Magnetizing Cells for Tracking | Science: Out of the Box

Although it has great potential for treating cancer, spinal cord injuries, diabetes and many other serious diseases, there are challenges to making stem cell therapy a reality. Watch cell imaging specialist Jeff Bulte explain his pioneering work in tracking stem cells in the body — and how it can help lead to better stem cell treatments by reporting stem cells’ location and whether they are still alive.

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