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The Hopkins Technology Center for Networks and Pathways of Lysine Modification is one of five centers supported by the NIH Roadmap Initiatives for Medical Research under its 2004 initiative to define Building Blocks, Biological Pathways, and Networks. Our common goal is to develop and disseminate new technologies, tools and databases that accelerate discovery and facilitate comprehensive study of biological pathways and networks. Techological innovation at each center is heavily focused on moving the field of proteomics beyond the static view afforded by interaction maps toward the creation of dynamic functional models with temporal and spatial resolution. Each center serves as a technology hub for the entire scientific community and its particular expertise and resources are available to all biomedical researchers. You are enthusiastically encouraged to contact these centers for collaborative assistance with challenging biomedical research problems.
Currently Funded Centers
Center on Proteolytic Pathways at Burnham Institute (La Jolla, CA)
The Center on Proteolytic Pathways (CPP) is a technology development hub to study how individual proteins assemble and interact in networks and pathways with emphasis in the area of proteases and proteolytic pathways. The main component of this work is PMAP, a protease reasoning environment. Databases, such as CutDB (a database for proteolytic events), allow researchers to compare proteolysis with other cellular pathways. The ultimate objective of the CPP is to comprehensively understand every protease encoded in the genome with respect to its regulation and substrate specificity.
Fluorescent Probes and Imaging for Networks and Pathways at Carnegie-Mellon University/University of Pittsburgh (Pittsburgh, PA)
This Molecular Biosensor and Imaging Center (MBIC) aims to develop novel fluorescent biosensors along with optical detection and imaging informatics technologies to detect molecular interactions and modifications within living cells.
Networks and Pathways of Lysine Modification at The Johns Hopkins University (Baltimore, MD)
New Tools for Exploring the Dynamic Interactome at Rockefeller University (New York, NY)
This National Center for Dynamic Interactome Research (NCDIR) seeks to develop radical new approaches to the detection, isolation and analysis of macromolecular complexes that will allow for comprehensive study of dynamic changes in complex composition and localization.
Polarity in Networks and Pathways at University of Connecticut School of Medicine and Dentistry (Farmington, CT)
This Center for Cell Analysis and Modeling (CCAM) integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics. CCAM focuses on new technologies for understanding the dynamic distributions of molecules in living cells. These tools address a fundamental problem of cell function: how signaling networks regulate, and are regulated by, the spatial organization of molecules in cells. The National Resource for Cell Analysis and Modeling (NRCAM) is a part of CCAM and is the home of the Virtual Cell Modeling and Simulation Framework.