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Investigator Roles

Core 1: Technology Development

Joel Bader (Acting PI)

Technology Center for Networks and Pathways of Lysine Modification: Acting PI & Project Leader of Computational Core 3

Jef D. Boeke (Former PI)

Technology Center for Networks and Pathways of Lysine Modification: Former PI & Project Leader of Core 1, Project 2, "Genetic Technologies for Assigning Proteins to Networks and Pathways"; Leader of Dissemination Core 5

  • Director, Institute for Systems Genetics, New York University Langone Medical Center
  • Professor, Department of Biochemistry & Molecular Pharmacology

Heng Zhu

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Project 1, "Analysis of Lysine Modification Using Protein Microarrays"

  • Associate Professor, HiT Center and Department of Pharmacology & Molecular Science

Akhilesh Pandey

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Project 3, "Qualitative and Quantitative Proteomic Analysis of Lysine Modifications"

  • Professor, Institute of Genetic Medicine and Department of Biological Chemistry

Robert Cotter

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 4, "Detecting and Mapping Protein Modifications by MALDI"

Philip Cole

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 5, "Affinity Labeling Agents for HAT Identification"

  • Director and E.K. Marshall and Thomas H. Maren Professor, Department of Pharmacology & Molecular Sciences

Andre Levchenko

Technology Center for Networks and Pathways of Lysine Modification: Core 1 and Computational Core 3

Jonathan Pevsner

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Training Core 4


Core 2: Driving Biological Projects (Newest to Oldest)

Jacques Côté

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Midi-DBP (2013) with Jef Boeke, Heng Zhu, Cole and Yingming Zhao, "Regulation of Nuclear Processes and Cell Fate by MYST-ING Lysine Acetyltransferase Complexes:  Identification of New Non-Histone Targets"

Peter Espenshade

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Akhilesh Pandey, "Methodology for Identification of E3 Ubiquitin Ligase Substrates" & Midi-DBP (2013), also with Akhilesh Pandey, "Methodology for Identification of Direct E3 Ubiquitin Ligase Substrates"

Gregory Bowman

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Midi-DBP (2013) with Jef Boeke and David Graham, "Identification of Histone-Remodeler Contacts Critical for Chromatin Remodeling"

Susan Michaelis

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Midi-DBP (2013) with Jef Boeke and Akhilesh Pandey, “Identification of Machinery and Mechanisms that Mediate Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast”

Martine Raymond

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Jef Boeke, "Inhibitors of H3K56 Deacetylation in Candida albicans"

Alan J. Tackett

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Sean Taverna, "Development of a Quantitative Assay for Comprehensive Analysis of Lysine Methylation"

Hening Lin

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Phil Cole, "Chemical Probes for Investigating the Function of Protein Lysine Malonylation and Succinylation"

Benjamin Tu

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project K, "Coordinating Dynamics of Gene Expression with Cellular Metabolic State as Revealed Through a Yeast Metabolic Cycle"

Sean Taverna

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project J, "Understanding the Dynamics of Histone Modifications at Distinct Genomic Loci Using
Antibody Arrays and Synthetic Chemistry"

  • Assistant Professor, Department of Pharmacology & Molecular Sciences

Yi Zhang

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project I, "Functional Characterization of the Histone Demethylases"

Harold Varmus

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project H, "Mutant Epidermal Growth Factor Receptor Signaling in Lung Cancer"

  • President, Memorial Sloan-Kettering Cancer Center
  • Lab Head: "Molecular mechanisms of oncogenesis and mouse models of cancer"; Program in Cancer Biology & Genetics

Oliver Rando

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project G, "Genomic and Proteomic Analyses of Chromatin Structure During the Yeast Cell Cycle"

  • Assistant Professor, Department of Biochemistry and Molecular Pharmacology
    University of Massachusetts Medical School

Cynthia Wolberger

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project F, "Substrates of the Sir2 Family of Enzymes"

Michael Matunis

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project E, "The Roles of Ubiquitin-like Modifiers in Regulating the Localization and Function of DNA Repair Proteins"

Robert E. Cohen for Cecile Pickart (1954-2006)

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project D, "Ubiquitylation and Polyubiquitin Dynamics and Networks"

Jorge Escalante-Semerena

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project C, "Acetylation/Deacetylation Pathways in Bacteria"

  • Professor, Bacteriology and Enzyme Institute
    University of Wisconsin-Madison, WI

Patrick Onyango

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project B, "SIRT3 NAD+-Dependent Deacetylase Network in Mitochondria"

Shelley Berger

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project A, "Covalent Modifications: Histones and Other Yeast Proteins"


TCNP of Lysine Modification: SPOKE GRANT RECIPIENTS

Nevan Krogan

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, "Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach"

  • Associate Professor, Department of Cellular and Molecular Pharmacology
    University of California, San Francisco

Sue Biggins

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, "Regulation of Centromeric Chromatin"


Core 6: Project Management

Pamela B. Meluh

Technology Center for Networks and Pathways of Lysine Modification: Program Manager

  • Research Associate, HiT Center and Department of Molecular Biology & Genetics