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Investigator Roles

Core 1: Technology Development

Joel Bader (Acting PI)

Technology Center for Networks and Pathways of Lysine Modification: Acting PI & Project Leader of Computational Core 3

Jef D. Boeke (Former PI)

Technology Center for Networks and Pathways of Lysine Modification: Former PI & Project Leader of Core 1, Project 2, "Genetic Technologies for Assigning Proteins to Networks and Pathways"; Leader of Dissemination Core 5

  • Director, Institute for Systems Genetics, New York University Langone Medical Center
  • Professor, Department of Biochemistry & Molecular Pharmacology

Heng Zhu

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Project 1, "Analysis of Lysine Modification Using Protein Microarrays"

Akhilesh Pandey

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Project 3, "Qualitative and Quantitative Proteomic Analysis of Lysine Modifications"

  • Professor, Institute of Genetic Medicine and Department of Biological Chemistry

Robert Cotter

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 4, "Detecting and Mapping Protein Modifications by MALDI"

Philip Cole

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 5, "Affinity Labeling Agents for HAT Identification"

Andre Levchenko

Technology Center for Networks and Pathways of Lysine Modification: Core 1 and Computational Core 3

Jonathan Pevsner

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Training Core 4


Core 2: Driving Biological Projects (Newest to Oldest)

Jacques Côté

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Midi-DBP (2013) with Jef Boeke, Heng Zhu, Cole and Yingming Zhao, "Regulation of Nuclear Processes and Cell Fate by MYST-ING Lysine Acetyltransferase Complexes:  Identification of New Non-Histone Targets"

Peter Espenshade

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Akhilesh Pandey, "Methodology for Identification of E3 Ubiquitin Ligase Substrates" & Midi-DBP (2013), also with Akhilesh Pandey, "Methodology for Identification of Direct E3 Ubiquitin Ligase Substrates"

Gregory Bowman

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Midi-DBP (2013) with Jef Boeke and David Graham, "Identification of Histone-Remodeler Contacts Critical for Chromatin Remodeling"

Susan Michaelis

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Midi-DBP (2013) with Jef Boeke and Akhilesh Pandey, “Identification of Machinery and Mechanisms that Mediate Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast”

Martine Raymond

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Jef Boeke, "Inhibitors of H3K56 Deacetylation in Candida albicans"

Alan J. Tackett

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Sean Taverna, "Development of a Quantitative Assay for Comprehensive Analysis of Lysine Methylation"

Hening Lin

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Mini-DBP (2011) with Phil Cole, "Chemical Probes for Investigating the Function of Protein Lysine Malonylation and Succinylation"

Benjamin Tu

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project K, "Coordinating Dynamics of Gene Expression with Cellular Metabolic State as Revealed Through a Yeast Metabolic Cycle"

Sean Taverna

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project J, "Understanding the Dynamics of Histone Modifications at Distinct Genomic Loci Using
Antibody Arrays and Synthetic Chemistry"

Yi Zhang

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project I, "Functional Characterization of the Histone Demethylases"

Harold Varmus

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project H, "Mutant Epidermal Growth Factor Receptor Signaling in Lung Cancer"

  • President, Memorial Sloan-Kettering Cancer Center
  • Lab Head: "Molecular mechanisms of oncogenesis and mouse models of cancer"; Program in Cancer Biology & Genetics

Oliver Rando

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project G, "Genomic and Proteomic Analyses of Chromatin Structure During the Yeast Cell Cycle"

  • Assistant Professor, Department of Biochemistry and Molecular Pharmacology
    University of Massachusetts Medical School

Cynthia Wolberger

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project F, "Substrates of the Sir2 Family of Enzymes"

Michael Matunis

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project E, "The Roles of Ubiquitin-like Modifiers in Regulating the Localization and Function of DNA Repair Proteins"

Robert E. Cohen for Cecile Pickart (1954-2006)

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project D, "Ubiquitylation and Polyubiquitin Dynamics and Networks"

Jorge Escalante-Semerena

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project C, "Acetylation/Deacetylation Pathways in Bacteria"

Patrick Onyango

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project B, "SIRT3 NAD+-Dependent Deacetylase Network in Mitochondria"

Shelley Berger

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project A, "Covalent Modifications: Histones and Other Yeast Proteins"


TCNP of Lysine Modification: SPOKE GRANT RECIPIENTS

Nevan Krogan

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, "Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach"

  • Associate Professor, Department of Cellular and Molecular Pharmacology
    University of California, San Francisco

Sue Biggins

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, "Regulation of Centromeric Chromatin"


Core 6: Project Management

Pamela B. Meluh

Technology Center for Networks and Pathways of Lysine Modification: Program Manager

  • Research Associate, HiT Center and Department of Molecular Biology & Genetics
 
 
 
 
 
 

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