Investigator Roles

Core 1:  Technology Development

Jef D. Boeke

Technology Center for Networks and Pathways of Lysine Modification: PI and Leader of Core 1, Project 2, “Genetic Technologies for Assigning Proteins to Networks and Pathways”

• Director, High Throughput Biology Center (HiT Center)
  
• Professor, Department of Molecular Biology & Genetics
  
• Professor, Department of Oncology
  

Heng Zhu

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Project 1, “Analysis of Lysine Modification Using Protein Microarrays”   

• Assistant Professor, HiT Center and Pharmacology & Molecular Science
  

Akhilesh Pandey

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Dissemination Core, Project 3, “Qualitative and Quantitative Proteomic Analysis of Lysine Modifications”; Leader, Core 5  

• Assistant Professor, Institute of Genetic Medicine and Department of Biological Chemistry
  

Robert Cotter

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 4, “Detecting and Mapping Protein Modifications by MALDI”

• Professor, Department of Pharmacology & Molecular Science
  

Philip Cole

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 5, “Affinity Labeling Agents for HAT Identification”

• Professor and Director, Department of Pharmacology & Molecular Science
  

Joel Bader

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Computational Core.

• Assistant Professor, HiT Center and Department of Biomedical Engineering
  

Andre Levchenko

Computational Core.

• Assistant Professor, Department of Biomedical Engineering

Jonathan Pevsner

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 4 – Training Core.

• Associate Professor and Director of the Bioinformatics Facility, Kennedy Krieger Institute
  
• Associate Professor, Department of Neuroscience
  

Core 2:  Driving Biological Projects (Newest to Oldest)

Benjamin Tu

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project K, “Coordinating Dynamics of Gene Expression with Cellular Metabolic State as Revealed Through a Yeast Metabolic Cycle”

• Assistant Professor, Department of Biochemistry
  University of Texas, Southwestern Medical Center

Sean Taverna

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project J, “Understanding the Dynamics of Histone Modifications at Distinct Genomic Loci Using
Antibody Arrays and Synthetic Chemistry”

• Assistant Professor, Department of Pharmacology and Molecular Sciences

Yi Zhang

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project I, “Functional Characterization of the Histone Demethylases”

• Professor, Department of Biochemistry and Biophysics
  University of North Carolina at Chapel Hill
  
• Investigator, Howard Hughes Medical Institute
  

Harold Varmus

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project H, “Mutant Epidermal Growth Factor Receptor Signaling in Lung Cancer"

• President, Memorial Sloan-Kettering Cancer Center
• Lab Head: "Molecular mechanisms of oncogenesis and mouse models of cancer"; Program in Cancer Biology & Genetics
  

Oliver Rando

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project G, “Genomic and Proteomic Analyses of Chromatin Structure During the Yeast Cell Cycle"

• Assistant Professor, Department of Biochemistry and Molecular Pharmacology
  University of Massachusetts Medical School
  

Cynthia Wolberger

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project F, “Substrates of the Sir2 Family of Enzymes”

• Professor, Department of Biophysics and Biophysical Chemistry
  
• Investigator, Howard Hughes Medical Institute
  

Michael Matunis

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project E, “The Roles of Ubiquitin-like Modifiers in Regulating the Localization and Function of DNA Repair Proteins”

• Assistant Professor, Department of Biochemistry and Molecular Biology
  Johns Hopkins University Bloomberg School of Public Health
  

Robert E. Cohen for Cecile Pickart (1954-2006)

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project D, “Ubiquitylation and Polyubiquitin Dynamics and Networks”

• Senior Scientist, Department of Biochemistry and Molecular Biology
  Johns Hopkins University Bloomberg School of Public Health
  

Jorge Escalante-Semerena

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project C, “Acetylation/Deacetylation Pathways in Bacteria”

• Professor, Bacteriology and Enzyme Institute
  University of Wisconsin-Madison, WI
  

Patrick Onyango

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project B, “SIRT3 NAD+-Dependent Deacetylase Network in Mitochondria”

• Assistant Professor, Department of Medicine – Medical Genetics
  

Shelley Berger

Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project A, “Covalent Modifications: Histones and Other Yeast Proteins”

• Professor, Gene Expression and Regulation Program
  Wistar Institute in Philadelphia, PA
  

TCNP of Lysine Modification: SPOKE GRANT RECIPIENTS

Nevan Krogan

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, “Genetic Analysis of the Nucleosome and RNA Polymerase II:  A Systems Approach”

• Assistant Professor, Department of Cellular and Molecular Pharmacology
  University of California, San Francisco

Sue Biggins

Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, “Regulation of Centromeric Chromatin”

• Associate Member, Basic Sciences
  Fred Hutchinson Cancer Research Center
  

Core 6:  Project Management

Pamela B. Meluh

Technology Center for Networks and Pathways of Lysine Modification: Program Manager

• Research Associate, Department of Molecular Biology & Genetics
  
• Research Associate, High Throughput Biology Center (HiT Center)