Core 1: Technology Development
Jef D. Boeke
Technology Center for Networks and Pathways of Lysine Modification: PI and Leader of Core 1, Project 2, “Genetic Technologies for Assigning Proteins to Networks and Pathways”
- Director, High Throughput Biology Center (HiT Center)
- Professor, Department of Molecular Biology & Genetics
- Professor, Department of Oncology
Heng Zhu
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Project 1, “Analysis of Lysine Modification Using Protein Microarrays”
Akhilesh Pandey
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 1, Dissemination Core, Project 3, “Qualitative and Quantitative Proteomic Analysis of Lysine Modifications”; Leader, Core 5
Robert Cotter
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 4, “Detecting and Mapping Protein Modifications by MALDI”
- Professor, Department of Pharmacology & Molecular Science
Philip Cole
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 1, Project 5, “Affinity Labeling Agents for HAT Identification”
- Professor and Director, Department of Pharmacology & Molecular Science
Joel Bader
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Computational Core.
Andre Levchenko
Computational Core.
Jonathan Pevsner
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 4 – Training Core.
- Associate Professor and Director of the Bioinformatics Facility, Kennedy Krieger Institute
- Associate Professor, Department of Neuroscience
Core 2: Driving Biological Projects (Newest to Oldest)
Benjamin Tu
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project K, “Coordinating Dynamics of Gene Expression with Cellular Metabolic State as Revealed Through a Yeast Metabolic Cycle”
Sean Taverna
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project J, “Understanding the Dynamics of Histone Modifications at Distinct Genomic Loci Using
Antibody Arrays and Synthetic Chemistry”
Yi Zhang
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project I, “Functional Characterization of the Histone Demethylases”
- Professor, Department of Biochemistry and Biophysics
University of North Carolina at Chapel Hill - Investigator, Howard Hughes Medical Institute
Harold Varmus
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project H, “Mutant Epidermal Growth Factor Receptor Signaling in Lung Cancer"
- President, Memorial Sloan-Kettering Cancer Center
- Lab Head: "Molecular mechanisms of oncogenesis and mouse models of cancer"; Program in Cancer Biology & Genetics
Oliver Rando
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project G, “Genomic and Proteomic Analyses of Chromatin Structure During the Yeast Cell Cycle"
- Assistant Professor, Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
Cynthia Wolberger
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project F, “Substrates of the Sir2 Family of Enzymes”
- Professor, Department of Biophysics and Biophysical Chemistry
- Investigator, Howard Hughes Medical Institute
Michael Matunis
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project E, “The Roles of Ubiquitin-like Modifiers in Regulating the Localization and Function of DNA Repair Proteins”
- Assistant Professor, Department of Biochemistry and Molecular Biology
Johns Hopkins University Bloomberg School of Public Health
Robert E. Cohen for Cecile Pickart (1954-2006)
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project D, “Ubiquitylation and Polyubiquitin Dynamics and Networks”
- Senior Scientist, Department of Biochemistry and Molecular Biology
Johns Hopkins University Bloomberg School of Public Health
Jorge Escalante-Semerena
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Core 2, Project C, “Acetylation/Deacetylation Pathways in Bacteria”
Patrick Onyango
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project B, “SIRT3 NAD+-Dependent Deacetylase Network in Mitochondria”
Shelley Berger
Technology Center for Networks and Pathways of Lysine Modification: Project Leader of Core 2, Project A, “Covalent Modifications: Histones and Other Yeast Proteins”
TCNP of Lysine Modification: SPOKE GRANT RECIPIENTS
Nevan Krogan
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, “Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach”
Sue Biggins
Technology Center for Networks and Pathways of Lysine Modification: Project Leader for Spoke Project, “Regulation of Centromeric Chromatin”
Core 6: Project Management
Pamela B. Meluh
Technology Center for Networks and Pathways of Lysine Modification: Program Manager




