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High Throughput Biology – HIT Center

Test tubes in rack

The High Throughput Biology Center, or HiT Center, of the Institute for Basic Biomedical Sciences is an interdisciplinary and interdepartmental effort led by Drs. Joel Bader, Heng Zhu and Seth Blackshaw. The three independent research labs that make up the HiT Center push the frontiers of research technologies and apply those techniques to fundamental questions of biology. The faculty members in the HiT Center combine approaches from a variety of disciplines including biology, physics, chemistry, mathematics, computer science and engineering, with the goal of selectively using high-throughput techniques to accelerate hypothesis-driven research and to speed development of new hypotheses. In addition to its active research programs, the HiT Center's core components offer resources to study interactions of chemical compounds, gene products, cells and organisms and the networks formed by these interactions. The Deep Sequencing & Microarray Core offers state-of-the art sequencing and array hybridization and analysis services. ChemCore is a compound screening and robotics service with access to compound libraries, and skill in assay development. The HiT Center also delivers gene-specific reagents to Hopkins researchers though Genomics Resources, which provides automated picking of bacteria-containing plasmids, lentilviral-ready shRNA clones, and yeast deletion (YKO) strains. The core services are located on the third floor of the Edward D. Miller Research Building. Besides standard offerings, scientific collaborations with HiT Center faculty have led to innovative technological solutions to research problems.