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School of Medicine
Viral Hepatitis Center
The Center has extensive programs in basic research related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, including:
|Clinical Research||Sulkowski||Clinical trials of interferon-based and small-molecule therapy for HCV infection|
|Epidemiology Pathogenesis||Thomas||Determinants of the progression of liver disease during chronic HCV infection|
Pathogenesis of HIV-HCV coinfection
|Human Genetics||Thio||Human genetic variation affecting the outcomes of HBV and HCV infections|
|HIV/HBV Coinfection||Treatment and virology of HBV and HIV coinfection|
|Immunology (Cellular)||Cox||Cellular immune responses to HCV during acute and chronic infectionCellular immune responses to HCV during acute and chronic infection|
Mechanisms of cellular immune failure during the transition from acute to chronic infection
|Balagopal||Microbial translocation and Kupffer cells in HIV-HCV coinfection|
In situ liver studies of HIV-HCV pathogenesis
|Virology / Evolution|
|Ray||Evolution and immune evasion of the HCV genome during acute and chronic infection|
Determinants of neutralization of HCV by antibodies
|Hepatitis C virus|
Humoral immune response
|Bailey||Study of immune responses against hepatitis C virus, particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus|
|Innate immunity to viruses|
|Chattergoon||Study of innate immune system responses against chronic viral infections including hepatitis C virus, hepatitis B, and HIV|
|Clinical research||Falade-Nwulia||Implementing rapid hepatitis C testing, training mid-level providers to treat hepatitis C|
|HIV/HCV||Irvin||HIV and HCV prevention and linkage to care/treatment interventions particularly as they intersect with the social determinants of health; Directs Generation Tomorrow and HIV/HCV training programs for students and community members for the Center for AIDS Research (CFAR)|