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Center for Cell Dynamics The Center for Cell Dynamics in Development and Disease focuses on the detection of spatially and temporally regulated molecular events in living cells, tissues and organisms. Essential cellular behaviors such as cytokinesis, chemotaxis, asymmetric cell division or changes in synaptic strength depend upon spatially localized, temporally dynamic biochemical reactions. Tens of thousands of these events, such as changes in protein or lipid phosphorylation, localization and binding occur in living cells every second. Yet current tools and technologies allow us to observe only a few as they actually occur. The Center for Cell Dynamics fosters interactions among scientists and cuts across traditional departmental boundaries with the common goal of using the most advanced technologies currently available for monitoring dynamic biochemical reactions in real time with the highest possible spatial resolution. We are recruiting new faculty members whose primary research focus will be to advance in a creative manner such approaches. We are developing new biosensors, which will allow us to monitor dozens of critical signaling pathways in real time. And we will employ these tools to investigate the fundamental cellular behaviors that underlie embryonic development, wound healing, and functions of the immune and nervous systems. These biosensors also have the potential to be developed into useful diagnostic and therapeutic tools for conditions such as cancer, nervous system disorders and auto-immune disease. | |||||||||||||||||||||||||||||||||||||||||
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