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 Message from the Director

 

Stephen Desiderio, M.D., Ph.D. Director
Stephen Desiderio,
M.D., Ph.D.
Director

I'm excited about the future. As an institution, Johns Hopkins is investing in fundamental science to a greater extent than seen in decades. Two new basic research buildings, one already completed and occupied, and one new cancer research building under construction are providing additional research space so Hopkins faculty, students, fellows and staff can expand efforts to probe the fundamental questions of biology, health and disease. As faculty, we're working harder than ever and taking advantage of Hopkins' great collegiality. There's hardly such a beast as an individual lab any more. Any single investigator has multiple collaborations that bridge gaps, break new ground, and bring new perspectives to some of science's most puzzling mysteries.

The IBBS is feeding that trend. We are identifying important resources and areas of expertise that will be critical as once separate research endeavors begin to overlap. One of these is the power inherent in looking at many samples, many genes, many cells, all at the same time. As a result, IBBS established the Intelligent High Throughput Biology Center, or HiT Center, a collection of faculty labs devoted to gene and protein microarrays, chemical screening, proteomics, and gene and protein synthesis and sequencing. IBBS faculty and others are considering what our next "center" might emphasize to help cross-pollinate science at the Johns Hopkins School of Medicine. Some options are:

  • Computational biology - studies in which computers are harnessed to model biological processes ranging from action of individual molecules to the workings of entire organs.
  • Genomics - a field that compares information on the genetic makeup of humans and animals to identify genes and what controls them, as well as to pinpoint mutations and other flaws in DNA.
  • Proteomics - research in which scientists track genes' production of specific proteins and explain how those proteins are used. Proteomics will reveal the impact of mutations, environmental factors or diseases on cells, telling how such things perturb overall cell biology.
  • Small molecular probes - a field in which scientists develop synthetic molecules capable of interfering with a cell's biology in order to pinpoint biological pathways and processes with new ease and precision.
  • Epigenetics - the study of genetic information other than the sequence of the genes themselves. Epigenetics is already known to play important roles in cancer, development and even behavior. Now scientists are ready to start examining epigenetics on the same scale used to determine genetic sequences; a remaining hurdle is technology.

I hope you are as excited as I am about what the future holds for Hopkins science.

Stephen Desiderio, M.D., Ph.D.
Director



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