Assistant Professor of Neurology
Director, Johns Hopkins Movement Disorder Fellowship Program
Director, Johns Hopkins Ataxia Center
Director, Johns Hopkins Ataxia Center
Appointment Phone:
410-550-5624
Primary Location:
Johns Hopkins Bayview Medical Center
Expertise:
Botulinum Toxin Injections, Cerebellar Ataxia, Dyskinesia, Dystonia, Movement Disorders, Neurology, Parkinson's Disease, Tremor
Locations
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Baltimore, MD 21224
Appointment Phone: 410-550-5624
Location Map
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Phone: 410-614-0577
Appointment Phone: 410-614-0577
Fax: 443-298-3933
Location Map
Johns Hopkins Outpatient Center
601 N. Caroline Street
Baltimore, MD 21287
Appointment Phone: 410-955-6700
Location Map
Department / Division
-
Neurology - Movement Disorders
Bio
Physician Title
Director, Johns Hopkins Movement Disorder Fellowship Program
Director, Johns Hopkins Ataxia Center
Director, Johns Hopkins Ataxia Center
Awards and Honors
Awards
2005 American Parkinson Disease Association Cotzias Fellowship
2003-5 Passano Physician-Scientist Award
2003 Herbert Friedberg Parkinson Disease Fellowship
2001 Preziosi Award for Clinical Excellence, chief resident in Neurology, Johns Hopkins
1997 Balder Scholarship Award for Outstanding Academic Achievement
1997 Summa cum Laude, University of Maryland School of Medicine
1996 Alpha Omega Alpha Medical Honor Society
1994 Phi Kappa Phi Honor Society
1997 Lange Medical Publications Award
1993-95 Medical Student Research Awards
1986 National Deans List/ B.A. w/ distinction in all subjects, Cornell University.
1982 Bausch and Lomb Science Award.
2005 American Parkinson Disease Association Cotzias Fellowship
2003-5 Passano Physician-Scientist Award
2003 Herbert Friedberg Parkinson Disease Fellowship
2001 Preziosi Award for Clinical Excellence, chief resident in Neurology, Johns Hopkins
1997 Balder Scholarship Award for Outstanding Academic Achievement
1997 Summa cum Laude, University of Maryland School of Medicine
1996 Alpha Omega Alpha Medical Honor Society
1994 Phi Kappa Phi Honor Society
1997 Lange Medical Publications Award
1993-95 Medical Student Research Awards
1986 National Deans List/ B.A. w/ distinction in all subjects, Cornell University.
1982 Bausch and Lomb Science Award.
Expertise
- Botulinum Toxin Injections
- Cerebellar Ataxia
- Dyskinesia
- Dystonia
- Movement Disorders
- Neurology
- Parkinson's Disease
- Tremor
Professional Highlights
PROFESSIONAL EXPERIENCE
1984 Summer Researcher National Institute of Mental Health, NIH
Advisor: David Jacobowitz, MD
1985-86 Summer Researcher National Institute of Mental Health, NIH
Advisor: Sanford Markey PhD
1995 Research Consultant Baltimore VA/ Department of Neurology
Advisor: Paul Fishman MD PhD
2003-present: Assistant Professor of Neurology Johns Hopkins School of Medicine
2003-present: Active Staff Johns Hopkins Hospital
2003-present: Courtesy Staff Johns Hopkins Bayview Medical Center
2008-present: Director Johns Hopkins Ataxia Center
2008-present Director Movement Disorder Fellowship Program
Johns Hopkins Department of Neurology
1984 Summer Researcher National Institute of Mental Health, NIH
Advisor: David Jacobowitz, MD
1985-86 Summer Researcher National Institute of Mental Health, NIH
Advisor: Sanford Markey PhD
1995 Research Consultant Baltimore VA/ Department of Neurology
Advisor: Paul Fishman MD PhD
2003-present: Assistant Professor of Neurology Johns Hopkins School of Medicine
2003-present: Active Staff Johns Hopkins Hospital
2003-present: Courtesy Staff Johns Hopkins Bayview Medical Center
2008-present: Director Johns Hopkins Ataxia Center
2008-present Director Movement Disorder Fellowship Program
Johns Hopkins Department of Neurology
Education and Experience
Training
- University of Maryland School of Medicine
- University of Maryland School of Medicine
Residencies
- Johns Hopkins Hospital (2001)
Fellowships
- Johns Hopkins Hospital (2003)
Certifications
- American Board of Psychiatry and Neurology (2002)
Centers/Institutes
Centers / Institutes
- Ataxia Center
- Parkinson's Disease and Movement Disorders Center
Research
Research and Publications
Publications (peer-reviewed)
1. Skofitsch G, Savitt JM, Jacobowitz DM. Suggestive Evidence for a Functional Unit between
Mast Cells and Substance P Fibers in the Rat Diaphragm and Mesentery. Histochem. 1985; 82: 5-8.
2. Skofitsch G, Zamir N, Helke CJ, Savitt JM, Jacobowitz DM. Corticotrophin Releasing Factor-Like Immunoreactivity in Sensory Ganglia and Capsaicin Sensitive Neurons of the Rat Central Nervous System: Colocalization with Other Neuropeptides. Peptides. 1985; 6: 307-318.
3. Johannessen JN, Savitt JM, Markey CJ, Bacon JP, Weisz A, Hanselman DS, Markey SP. The Development of Amine Substituted Analogues of MPTP as Unique Tools for the Study of MPTP Toxicity and Parkinsons Disease. Life Sciences. 1987; 40: 697-704.
4. Fishman PS, Savitt JM. Selective Localization by Neuroglia of Immunoglobulin G in Normal Mice. Journal of Neuropathology and Experimental Neurology. 1989; 48(2): 212-220.
5. Fishman PS, Savitt JM. Transsynaptic Transfer of Retrogradely Transported Tetanus Protein-Peroxidase Conjugates. Experimental Neurology, 1989; 106: 197-203.
6. Fishman PS, Savitt JM, Farrand DA. Enhanced CNS Uptake of Systemically Administered Proteins Though Conjugation with Tetanus C-Fragment. J. Neurol. Sci. 1990; 98: 311-325.
7. Savitt JM, Trisler D, Hilt DC. Molecular Cloning of TOPAP: A Topographically Graded Protein in the Developing Chick Visual System. Neuron. 1995; 14: 253-261.
8. Figueiredo DM, Hallewell RA, Chen LL, Fairweather NF, Dougan G, Savitt JM, Parks DA, Fishman PS. Delivery of Recombinant Tetanus-Superoxide Dismutase Proteins to Central Nervous System Neurons by Retrograde Axonal Transport. Experimental Neurology. 1997; 145: 546-54.
9. Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci. 2004;101 (29):10744-9.
10. Savitt JM, Jang SS, Mu W, Dawson VL, Dawson TM. Bcl-x is required for the proper development of the mouse substantia nigra. J. Neurosci. 2005; 25: 6721-6728.
11. Von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion Body Formation and Neurodegeneration are Parkin-independent in a Mouse Model of Alpha-Synucleinopathy. J. Neurosci. 2006; 26(14):3685-3696
12. Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease, molecules to medicine. J. Clin. Invest. (2006) 116: 1744-1754.
13. Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 2006; 60(5):557-569.
14. The NINDS NET-PD Investigators. A Randomized Clinical Trial of Coenzyme Q10 and GPI-1485 in Early Parkinson Disease. Neurology. 2007; 68(1): 20-8.
15. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty, DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of non-peptidergic DRG neurons. Neuron. 2007; 54: 739-754.
16. The Parkinson Study Group. The Mixed Lineage Kinase Inhibitor CEP-1347 Fails to Delay Disability in Early Parkinsons Disease. Neurology. 2007; 69:1480-1490
17. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A; Parkinson Study Group PRECEPT Investigators, Hyson C, Gorbold E, Rudolph A, Kieburtz K, Fahn S, Gauger L, Goetz C, Seibyl J, Forrest M, Ondrasik J. Serum urate as a predictor of clinical and radiographic progression in Parkinsons disease. Arch Neurol 2008; 65(6) 716-23.
18. Tsang AKH, Lee Y, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson, VL, Dawson TM, Chung, KK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson''s disease. PNAS. 2009 106(12) 4900-5.
1. Skofitsch G, Savitt JM, Jacobowitz DM. Suggestive Evidence for a Functional Unit between
Mast Cells and Substance P Fibers in the Rat Diaphragm and Mesentery. Histochem. 1985; 82: 5-8.
2. Skofitsch G, Zamir N, Helke CJ, Savitt JM, Jacobowitz DM. Corticotrophin Releasing Factor-Like Immunoreactivity in Sensory Ganglia and Capsaicin Sensitive Neurons of the Rat Central Nervous System: Colocalization with Other Neuropeptides. Peptides. 1985; 6: 307-318.
3. Johannessen JN, Savitt JM, Markey CJ, Bacon JP, Weisz A, Hanselman DS, Markey SP. The Development of Amine Substituted Analogues of MPTP as Unique Tools for the Study of MPTP Toxicity and Parkinsons Disease. Life Sciences. 1987; 40: 697-704.
4. Fishman PS, Savitt JM. Selective Localization by Neuroglia of Immunoglobulin G in Normal Mice. Journal of Neuropathology and Experimental Neurology. 1989; 48(2): 212-220.
5. Fishman PS, Savitt JM. Transsynaptic Transfer of Retrogradely Transported Tetanus Protein-Peroxidase Conjugates. Experimental Neurology, 1989; 106: 197-203.
6. Fishman PS, Savitt JM, Farrand DA. Enhanced CNS Uptake of Systemically Administered Proteins Though Conjugation with Tetanus C-Fragment. J. Neurol. Sci. 1990; 98: 311-325.
7. Savitt JM, Trisler D, Hilt DC. Molecular Cloning of TOPAP: A Topographically Graded Protein in the Developing Chick Visual System. Neuron. 1995; 14: 253-261.
8. Figueiredo DM, Hallewell RA, Chen LL, Fairweather NF, Dougan G, Savitt JM, Parks DA, Fishman PS. Delivery of Recombinant Tetanus-Superoxide Dismutase Proteins to Central Nervous System Neurons by Retrograde Axonal Transport. Experimental Neurology. 1997; 145: 546-54.
9. Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci. 2004;101 (29):10744-9.
10. Savitt JM, Jang SS, Mu W, Dawson VL, Dawson TM. Bcl-x is required for the proper development of the mouse substantia nigra. J. Neurosci. 2005; 25: 6721-6728.
11. Von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion Body Formation and Neurodegeneration are Parkin-independent in a Mouse Model of Alpha-Synucleinopathy. J. Neurosci. 2006; 26(14):3685-3696
12. Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease, molecules to medicine. J. Clin. Invest. (2006) 116: 1744-1754.
13. Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 2006; 60(5):557-569.
14. The NINDS NET-PD Investigators. A Randomized Clinical Trial of Coenzyme Q10 and GPI-1485 in Early Parkinson Disease. Neurology. 2007; 68(1): 20-8.
15. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty, DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of non-peptidergic DRG neurons. Neuron. 2007; 54: 739-754.
16. The Parkinson Study Group. The Mixed Lineage Kinase Inhibitor CEP-1347 Fails to Delay Disability in Early Parkinsons Disease. Neurology. 2007; 69:1480-1490
17. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A; Parkinson Study Group PRECEPT Investigators, Hyson C, Gorbold E, Rudolph A, Kieburtz K, Fahn S, Gauger L, Goetz C, Seibyl J, Forrest M, Ondrasik J. Serum urate as a predictor of clinical and radiographic progression in Parkinsons disease. Arch Neurol 2008; 65(6) 716-23.
18. Tsang AKH, Lee Y, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson, VL, Dawson TM, Chung, KK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson''s disease. PNAS. 2009 106(12) 4900-5.
Research Interests
- GDNF
- Ubiquitin
- Autophagy
- Ataxia
- Neurodegeneration
- Movement Disorders
More Info
Languages
- English
Memberships
ORGANIZATIONAL ACTIVITIES
Ad Hoc Journal Peer Review: J. Neuroscience (2006, 2008);
J. Neurochemistry (2007-2009)
Cleveland Clinic Journal of Medicine (2008)
BBA Molecular Basis of Disease (2008)
Molecular and Cellular Neuroscience (2009)
Grant Review: Michael J. Fox Community Fast Track Review committee 2006-2009.
Michael J. Fox Rapid Response Innovation Awards 2009.
Parkinsons disease Society UK 2007.
Parkinson Study Group Scientific Review Committee Term 2007-2010.
Professional Societies: Parkinsons Study Group (2005- present), member of the working group on genetics and environmental risk.
American Academy of Neurology (1998-present)-Member
movement disorder section member.
Movement Disorder Society (2002-present)-Member.
Society for Neuroscience (1994-present)-Member.
National Ataxia Foundation (2008-present)-Member.
A-team member Chesapeake Chapter- National Ataxia Foundation.
Awards
Ad Hoc Journal Peer Review: J. Neuroscience (2006, 2008);
J. Neurochemistry (2007-2009)
Cleveland Clinic Journal of Medicine (2008)
BBA Molecular Basis of Disease (2008)
Molecular and Cellular Neuroscience (2009)
Grant Review: Michael J. Fox Community Fast Track Review committee 2006-2009.
Michael J. Fox Rapid Response Innovation Awards 2009.
Parkinsons disease Society UK 2007.
Parkinson Study Group Scientific Review Committee Term 2007-2010.
Professional Societies: Parkinsons Study Group (2005- present), member of the working group on genetics and environmental risk.
American Academy of Neurology (1998-present)-Member
movement disorder section member.
Movement Disorder Society (2002-present)-Member.
Society for Neuroscience (1994-present)-Member.
National Ataxia Foundation (2008-present)-Member.
A-team member Chesapeake Chapter- National Ataxia Foundation.
Awards
Clinical Trials
- Neuroprotection
- Botulinum Toxin Injection
- Parkinson Disease
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