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CONTROLLING WEIGHT

CAN A NEW CLASS OF INHIBITORS HELP WITH WEIGHT GAIN AND DIABETES?  ELIZABETH TRACEY REPORTS

Ghrelin is the name of a hormone involved in regulation of feeding behavior.  Philip Cole and colleagues at Johns Hopkins have been studying this hormone for some time with an eye toward weight control and perhaps prevention of type 2 diabetes.

COLE: Ghrelin was discovered in 1999 as a peptide hormone which could have effects on weight and ultimately shown to have effects on blood sugar.                  :11

Now Cole and his lab have published results on an exciting ghrelin inhibitor known by the bucolic abbreviation of GOAT.

COLE:  This paper develops the first inhibitors that work in animals that block fatty acid modification of an important hormone called ghrelin.  The ability to block this modification is associated with prevention of weight gain and improved blood sugars.     :16

The research also furthers understanding of the connection between excess weight and diabetes.  At Johns Hopkins, I’m Elizabeth Tracey.


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