ANCHOR LEAD: A SURGICAL APPROACH THROUGH THE EYELID ALLOWS ACCESS TO THE BRAIN, ELIZABETH TRACEY REPORTS
Hundreds of thousands of Americans are affected by a condition called sarcoidosis, where tiny clumps of grainy cells called granulomas form in all the major organs, and may cause death. Now a Johns Hopkins study led by Edward Chen has found that a protein called amyloid a is involved.
CHEN: We looked for the presence of a family of proteins called amyloid proteins. The one that we actually found was the serum amyloid and the striking finding on the biopsies of the granulomas were basically chockfull of this protein. And it was just hard to ignore the possibility that this must really play some role in the development. :17
Amyloid a also causes inflammation and sets off a cascade of reactions that are likely targets for intervention, Chen says.
CHEN: If we were able to understand sarcoidosis a little bit better perhaps better therapies could be developed. :05
The hope is that these patients could avoid using steroids. At Johns Hopkins, I’m Elizabeth Tracey.