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PROSTATE CANCER AND CHOLESTEROL?

ANCHOR LEAD: WHAT IS THE CONNECTION BETWEEN HIGH CHOLESTEROL AND PROSTATE CANCER?  ELIZABETH TRACEY REPORTS

Men with higher cholesterol levels may experience more aggressive prostate cancer.  That’s a finding of a Johns Hopkins study led by Elizabeth Platz.  But why is high blood cholesterol related to more aggressive forms of prostate cancer? Platz responds.

PLATZ:  There are signaling pathways that are cholesterol dependent.  And it’s long been known that prostate cancer cells exhibit cholesterol dysregulation.   So it is absolutely possible that changing cholesterol  levels might indeed change the likelihood of survival of cancer cells.  We don’t know exactly if that’s the mechanism at this time.  We do have colleagues who are investigating that pathway.  :26

For now, it’s too early to suggest that cholesterol lowering medications such as statins should be used to reduce a man’s chance of aggressive prostate cancer, but Platz says studies are ongoing. At Johns Hopkins, I’m Elizabeth Tracey.



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