ANCHOR LEAD: STUDYING PROSTATE CANCER THAT HAS SPREAD GIVES IMPORTANT INFORMATION, ELIZABETH TRACEY REPORTS
Taking a very close look at DNA from the original prostate cancer tumor as well as that from distant sites to which the cancer metastasized has led Steven Bova and colleagues to conclude that just one cell, and one set of genetic alterations, is enough to create disease that will spread and result in death.
BOVA: There’s probably many roads that lead to the departure terminal for a prostate cancer cell. If we’re able to find blockers of specific pathways in these cells we’ll be able to look at cells from either in the prostate or that have already spread, and you’ll be able to say well this cancer cell has these vulnerabilities. These are the best ways that we know right now to arrest its ability to grow or potentially even to eliminate it. :28
Finding a way to identify prostate cancer that is likely to spread would help determine who needs to be aggressively treated. At Johns Hopkins, I’m Elizabeth Tracey