AMYLOID AND ALZHEIMER’S
ANCHOR LEAD: HOW IMPORTANT IS AMYLOID IN THE DEVELOPMENT OF ALZHEIMER’S DISEASE? ELIZABETH TRACEY REPORTS
Accumulation of a protein-based material called amyloid in the brain appears to be important in the development of Alzheimer’s disease, but no one is sure just how important. Now a study in the New England Journal of Medicine seems to suggest that in older people, other factors may be equally or even more important. Constantine Lyketsos, an Alzheimer’s disease expert at Johns Hopkins, comments.
LYKETSOS: There’s not a straight line relationship. We call this the Alzheimer cascade. Amyloid seems to be an important part of getting dementia due to Alzheimer’s but its not sufficient, and what this is pointing out is as people get older the role of non-amyloid factors becomes increased. Those other factors might be brain vascular disease, or just other comorbidities. :22
Comorbidities, or other medical conditions, could include things like cardiovascular disease, diabetes, or high blood lipid levels. At Johns Hopkins, I’m Elizabeth Tracey.