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LOWER DOSE

ANCHOR LEAD:  USING A LOWER DOSE OF CHEMOTHERAPY MAY BE VERY HELPFUL IN SOME CANCERS, ELIZABETH TRACEY REPORTS

Tumors need oxygen to grow, so they secrete factors that help stimulate new blood vessel growth to supply their needs.  A team at Johns Hopkins led by Gregg Semenza has shown that low, daily doses of a certain class of chemotherapy drugs helps block production of these growth factors.

SEMENZA:  What we showed is that there are proteins, factors that are made by the cancer, which stimulate blood vessel formation, and when we treat with adriamycin or doxorubicin, one of these chemotherapy agents, we can block the production of these growth factors for blood vessels within the tumor, when we treat with lower doses of these agents on a daily basis.                       :22

Semenza says it’s important to understand the pathways and steps that are involved in new blood vessel formation to tumors in order to specifically inhibit cancer-related processes only.  I’m Elizabeth Tracey reporting.


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