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GENES AND SCHIZOPHRENIA

ANCHOR LEAD: SEVERAL GENES ARE INVOLVED IN THE DEVELOPMENT OF SCHIZOPHRENIA, ELIZABETH TRACEY REPORTS

As more is understood about genes, it’s becoming clear that most diseases and conditions involve more than one gene, often sequentially, along with environmental factors such as viral infections or exposure to certain chemicals.  Schizophrenia is no exception, says Akira Sawa, a psychiatrist and researcher at Johns Hopkins.

SAWA:  In schizophrenia genetic component play a very important role, but none of the schizophrenia is caused by only one genetic factor.  But multiple genetic factor interact with each other and cause the disorder.                 :14

Sawa and colleagues have just identified a link between three proteins involved in schizophrenia.

SAWA:  This would be probably the first time to demonstrate that how more than one genetic risk factor interact with each other and cause the disease associated pathologies.  :11

Sawa says this linkage is important because it provides a target for therapeutic interventions but also demonstrates the importance of gene interactions.  I’m Elizabeth Tracey reporting.


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