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APPETITE SUPRESSION

ANCHOR LEAD: CUTTING OFF THE BLOOD SUPPLY TO CERTAIN PARTS OF THE STOMACH MAY CUT APPETITE, ELIZABETH TRACEY REPORTS

Ghrelin is a hormone discovered several years ago that looked to be the holy grail of appetite regulation, and then panned, like so many others before it.  Now a new technique developed at Johns Hopkins by Aravind Arepally and colleagues has brought ghrelin back into the limelight.

AREPALLY:  There’s a certain part of the stomach that produces ghrelin, which is a hormone known to produce these strongest appetite urges, so we catheterize the blood vessels and we target only that specific part of the stomach that produces ghrelin, and we injected this chemical that basically causes a focal ablation of that tissue, and by doing that we were able to suppress appetite for up to one month.  We did the same exact procedure with another five of the animals where we just did saline.  The ones that had the chemical injected we were able to suppress their appetite whereas the ones that just had saline nothing happened to them.                        :30

Arepally says it will be some time before the technique can be tried in humans but these early results look promising.  I’m Elizabeth Tracey reporting.


-- JHMI --
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