ANCHOR LEAD: AN OLD EQUATION PROVES HELPFUL IN DESIGNING STRATEGIES TO KEEP HIV IN CHECK, ELIZABETH TRACEY REPORTS
Taking a second look at an equation that’s been around for quite some time has allowed Johns Hopkins researchers to develop a new tool to help predict which drugs will be most effective against HIV infection. Robert Siliciano, the study’s senior investigator, says use of this formula could really benefit people who are infected.
SILICANO: Our work is based on some classic pharmacology equations actually based on some work at Hopkins that describe how well drugs inhibit things like viral replication. Interestingly, one of the variables in this classical equation has traditionally been ignored or thought not to be important and this previously ignored factor had a huge impact on how well drugs inhibit the virus. :26
Since viral inhibition depends on a combination of medications that may be unique for each patient, being able to predict which of them will be most effective is critical to keeping the virus in check. I’m Elizabeth Tracey reporting.