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GENETIC LINK TO BOWEL DISEASE

ANCHOR LEAD: RESEARCH IS HOMING IN ON A GENETIC BASIS FOR CROHN’S DISEASE, ELIZABETH TRACEY REPORTS

Crohn’s disease is a common inflammatory disease of the bowel that can be quite serious and difficult to manage.  Now researchers lead by Steven Brant, an inflammatory bowel disease and genetics expert at Johns Hopkins, are coming closer to identifying genes that may be involved.

BRANT:  We haven’t actually identified a particular mutation, that’s the end goal of our research.  We’ve identified chromosomal segments using snps, that’s single nucleotide polymorphisms, that show that these segments are shared in persons within a family that have Crohn’s disease, as opposed to the persons within a family that don’t have Crohn’s disease.  By finding these variants we may be able to predict who in a family may get the disease.                     :29

Brant says a clearer picture of which gene or genes are responsible will help researchers develop very specific therapies to manage or even cure the condition and may have implications for other inflammatory diseases as well.  I’m Elizabeth Tracey reporting.

 


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