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HDL AND LDL

ANCHOR LEAD : HOW MUCH CAN WE MANIPULATE CHOLESTEROL COMPONENTS WITH MEDICATION?  ELIZABETH TRACEY REPORTS

A new type of medication to lower LDL- that’s low density lipoprotein, often called “bad cholesterol,” may cause more problems than benefits, according to a recent study in the New England Journal of Medicine.  Just how much can or should we manipulate LDL and it’s beneficial brother, HDL?  Rick Lange, chief of clinical cardiology at Johns Hopkins, comments.

LANGE:  The current medications that we have for raising HDL or lowering LDL have some untoward side effects.  This particular issue of the New England Journal points one of those out.  This new medication that was tested lowers LDL by a different mechanism than statins.  The unfortunate thing is it causes fatty liver.  Fatty liver ends up being a major cause of liver failure.  Several weeks ago one of the medications used to raise HDL was taken off the market, because although it was effective in raising HDL, it increased the incidence of high blood pressure and actually had more adverse cardiovascular effects than one would expect.            :34

Lange says everyone should try diet and exercise, and weight loss if needed, before any medication.  I’m Elizabeth Tracey reporting. 

 


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