MARY S. LEFFELL, Ph. D., Diplomate, ABHI, ABMLI
PUBLISHED ARTICLES
 

Leffell MS and Spitznagel JK:  Association of lactoferrin with lysozyme in granules of human polymorphonuclear leukocytes. Infection and Immunity, 6:761-765, 1972.

Brune K, Leffell MS and Spitznagel JK:  Microbial activity of peroxidaseless chicken heterophil leukocytes. Infection and Immunity, 5:283-287, 1972.

Leffell MS and Spitznagel JK:  Intracellular and extracellular degranulation of human PMN azurophil and specific granules induced by immune complexes.  Infection and Immunity, 10:1241-1249, 1974.

Spitznagel JK, Dalldorf JG, Leffell MS, and Folds JD:  Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.  Laboratory investigations, 30:774-785, 1974.

Leffell MS and Spitznagel JK:  Fate of human lactoferrin and myeloperoxidase in phagocytizing human neutrophils: Effects of immunoglobulin G subclasses and immune complexes coated on latex beads.  Infection and Immunity, 12:813-832, 1975.

Leffell MS and Coggin JH, Jr:  Common transplantation rejection antigens on methylcholanthrene induced sarcomas detected by three assays of tumor rejection.  Cancer Research, 37:4112-4119, 1977.

Leffell MS and Coggin JH, Jr:  Increases and perturbations in thymocytes forming spontaneous rosettes during viral and chemical oncogenesis in hamsters.  Clinical Immunology and Immunopathology, 11:275-287, 1978.

Leffell MS and Folds JD:  Complement: A brief review of its use in immunodiagnosis.  Public Health Laboratory, 36:116-123, 1978.

Leffell MS, Folds JD and Wasilauskas B:  Counterimmunoelectrophoretic detection of a high incidence of precipitin reactions in normal human sera against staphylococcal teichoic acids and protein A.  Journal of Clinical Microbiology, 8:591-597, 1978.

Wright GL, Jr., Schellhammer PF, Brassil DN, Sieg SM and Leffell MS: Comparison of countercurrent immunoelectrophoretic assay with commercial radioimmunoassay kits for measuring prostatic acid phosphatase.  Clinical Chemistry, 27(10):1747-1752, 1981.

Vande Berg JS, Devine CJ, Horton CE, Somers KD, Wright GL, Jr., Leffell MS, Dawson SM, Gleischman SH and Rowe MJ:  Peyronie's Disease: An electron microscopic study.  Journal of Urology, 126:333-336, 1981.

Vande Berg JS, Devine CJ, Horton CE, Somers KD, Wright GL, Jr., Leffell MS, Dawson DM, Gleischman SH and Rowe MJ:  Mechanisms of calcification in Peyronie's disease.  Journal of Urology, 127:52-54, 1982.

Somers KD, Dawson DM, Wright GL, Jr., Leffell MS, Rowe MJ, Bluemink GG, Vande Berg JS, Gleischman SH, Devine CJ, Jr. and Horton CE:  Cell culture of Peyronie's Disease plaque and normal penile tissue.  Journal of Urology, 127:585-588, 1982.

Leffell MS, Devine CJ, Jr., Horton CE, Somers KD, Dawson DM, Vande Berg JS, Bluemink GG and Wright GL, Jr:  Non-association of Peyronie's disease with HLA B-7 cross-reactive antigens.  Journal of Urology, 127:1223-1224, 1982.

Wright GL, Schellhammer PF, Leffell MS, Sieg SM and Brassil DN: Radioimmunoassay versus counterimmune electrophoresis for measurement of serum prostatic acid phosphatase.  Urology, XIX:351-355, 1982.

Levy DL, Cox AD, Leffell MS and Wilds PL:  Serum complement activity in preterm pregnancies: Relationships to duration of ruptured membranes and clinical infection.  American Journal of Reproductive Immunology, 2:142-147, 1982

Mattern WD, Hak LJ, Lamanna RW, Teasley KM and Leffell MS: Malnutrition, altered immune function, and the risk of infection in maintenance hemodialysis patients.  American Journal of Kidney Diseases, 1(4):206-218, 1982.

Hak LJ, Leffell MS, Lamanna RW, Teasley KM, Bazzarre CH and Mattern WD:  Reversal of skin test energy during maintenance hemodialysis by protein and calorie supplementation.  American Journal of Clinical Nutrition, 36:1089-1092, 1982.

Rohn RD, Leffell MS, Johnson D and Rubio T:  Familial third-fourth pharyngeal pouch syndrome with apparent autosomal dominant transmission.  Journal of Pediatrics, 105:47-51, 1984.

Leffell MS, Lumsden L and Steiger WA:  Analysis of T Lymphocyte subpopulations in Alzheimer's disease.  Journal of the American Geriatrics Society, 33:4-8, 1985.

Somers KD, Winters BA, Dawson DM, Leffell MS, Wright GL, Devine CJ, Gilbert DA and Horton CE:  Chromosomal abnormalities in Peyronie's disease.  Journal of Urology, 137:672-675, 1987.

Bowen PA, Lobel SA, Caruana RJ, Leffell MS, House MA, Rissing JR and Humphries AL:  Transmission of human immunodeficiency virus by transplantation: clinical aspects and time course analysis of viral antigenemia and antibody production.  Annals of Internal Medicine, 108:46-48, 1988.

Perrick D, Wray BB, Guill MF, Leffell MS and Lobel S:  Use of transfer factor in a pediatric AIDS patient with disseminated mycobacterium avium intracellulare.  Annals of Allergy, 62:437-440, 1989.

Moffitt JE, Guill MF, Leffell MS, Ades EW, Burek CL, Lobel SA and Hoffman SA:  Type I diabetes in an adolescent with common variable immunodeficiency.  Journal of  Allergy and Clinical Immunology, 84:191-196, 1989.

Caruana RJ, Lobel SA, Leffell MS, Campbell H and Cheek PL:  Tumor necrosis factor, interleukin-1 and beta 2-microglobulin levels in chronic hemodialysis patients.  International Journal of Artificial Organs, 13(12):794-8, 1990.

Perrick D, Wray BB, Leffell MS, Harmon JD and Porubsky ES:  Evaluation of immunocompetency in juvenile laryngeal papillomatosis.  Annals of Allergy, 65:69-72, 1990.

Mackert RJ, Jr., Leffell MS, Wagner DA and Powell BJ:  Lymphocyte levels in subjects with and without amalgam restorations.  Journal of the American Dental Association, 122:49-53, 1991.

Wise SL, Yarbrough JA, Leffell MS, Ades E and Stafford CT:  In vitro effects of interleukin-2 and gamma globulin on immune dysfunction in a patient with severe mucocutaneous Herpes simplex infection.  Annals of Allergy, 68:47-52, 1992.

Caruana RJ, Leffell MS, Lobel SA, Campbell HT and Cheek PL:  Chronic T-lymphocyte activation in chronic renal failure: a study of hemodialysis, CAPD and pre-dialysis patients. International Journal of Artificial Organs, 15(2):93-8, 1992.

Hart JM, Zemmour J, Schmeckpeper BJ, Parham P, Wood WH, Hopkins KA, Leffell MS and Bias WB:  The occurrence of HLA-B46 in two Caucasoid Families.  Tissue Antigens, 41:47-50, 1993.

Leffell MS, Steinberg AG, Bias WB, Machan CH and Zachary AA:  The Distribution of HLA Antigens and Phenotypes Among Donors and Patients in the UNOS Registry.  Transplantation, 58:1119-1130, 1994.

Zachary AA, Griffin J, Lucas DP, Hart JM and Leffell MS:  Evaluation of HLA Antibodies with the PRA - STAT™ test: An ELISA test using soluble HLA class I molecules.  Transplantation, 60: 1600-1606, 1995.

Zachary AA, Steinberg AG, Bias WB and Leffell MS:  The Frequencies of HLA alleles and haplotypes and their distribution among Donors and Renal Patients in the UNOS Registry.  Transplantation, 62: 272-283, 1996.

Leffell MS:  Is there and Immunogenetic Basis for Peyronies’ Disease? Journal of Urology, 157:295-297, 1997.

Zachary AA, Hart JM, Bartlett ST, Burdick J, Colombani P, Ratner LE and Leffell MS:  Local Impact of 1995 Changes in the Renal Transplant Allocation System.  Transplantation, 63:669-674, 1997.

Zachary AA, Vogelsang GB, Steinberg AG and Leffell MS:  Strategies for Determining HLA Compatibility in Related Donor Bone Marrow Transplantation.  Transplantation, 64:828-835, 1997.

Leffell MS, Bennett LE, Ellison MD and Zachary AA:  Impact of Changes in the UNOS Renal Allocation System.  Transplantation Proceedings, 29:3435-3436, 1997.

Leffell MS:  Your Health: HLA, Transplantation and Alaska Natives.  The YKHC Messenger, Bethel, Alaska, October 1997.

Zachary AA, Leffell MS, Johnson A, Rose SM, and Bias WB:  HLA antigens, alleles, and haplotypes among African-Americans.  Transplantation Proceedings 29: 3706, 1997.

Alexander RB, Brady F, Leffell MS, Tsai V and Celis E:  Specific recognition of peptides derived from prostate-specific antigen in patients with prostate cancer.  Urology, 51(1):150-157, 1998.

Leffell MS and Zachary AA:  The national impact of the 1995 changes to the UNOS renal allocation system.  Clinical Transplantation, 13:287-295, 1999.

Zachary AA, Ratner L, Montgomery R, Fivush B, Neu A, Colombani P, Wise B, Lucas D, Delaney N and Leffell MS:  Changes in Alloantibody Specificity Following Plasmapheresis and IVIG.  In: Visuals of Clinical Histocompatibility Workshop (P.I. Terasaki, ed.).  One Lambda, Inc., Los Angeles, 1999, pp. 44-45.

Leffell MS, Ratner L, Montgomery R, Fivush B, Neu B, Colombani P, Wise B, Lucas D, Delaney N and Zachary AA:  Abrogation of Humoral Rejection by Removal of HLA-Specific Antibody.  In: Visuals of Clinical Histocompatibility Workshop (P.I. Terasaki, ed.).  One Lambda, Inc., Los Angeles, 1999, pp. 46-47.

Montgomery RA, Zachary AA, Racusen LC, Leffell MS, King K, Burdick J, Maley WR, and Ratner LE:  Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into crossmatch positive recipients.  Transplantation, 70: 887-895, 2000.

Leffell MS, Vogelsang GB, Lucas DP, Delaney NL, and Zachary AA: Association between TGF  expression and severe GVHD in allogeneic bone marrow transplantation.  Transplantation Proceedings 33: 485-6, 2001.

Zachary AA, Ratner LE, and Leffell MS:  Low levels of HLA-specific antibody: relevance, detection and treatment.  Transplantation Proceedings 33:469-70, 2001.

Zachary AA, Delaney NL, Lucas DP, and Leffell MS:  Characterization of HLA class I-specific antibodies by ELISA using solubilized antigen targets: 1. Evaluation of the GTI QuikID™ Assay and Analysis of Antibody Patterns.  Human Immunology 62: 228-35, 2001.

Zachary AA, Ratner LE, Graziani JA, Lucas DP, Delaney NL, and Leffell MS:  Characterization of HLA class I-specific antibodies by ELISA using solubilized antigen targets: 2. Clinical Relevance.  Human Immunology 62: 236-46, 2001.

Ellexson-Tuner ME, Leffell MS, Zachary AA, Turner S, Bennett T, Sidebottom DA, Cao K, Fernadez-Vina M, and Hildebrand WH:  Detection of New HLA Class I Alleles in Alaskan Yupik Eskimo.  Human Immunology 62: 639-44, 2001.

Leffell MS, Kraus E, Racusen LC, Ratner LE, Charney D, and Zachary AA: The effect of Bw4and Bw6 epitope mismatches on antibody production, acute and chronic rejection and graft survival in renal allografts. Transplantation 72:433-7, 2001.

Zachary AA, Bias WB, Johnson A, Rose SM, and Leffell MS:  Antigen, Allele, and Haplotype Frequencies: Report of the ASHI Minority antigens Workshops: Part 1, African-Americans.  Human Immunology 62:1127-36, 2001.

Mignot E, Lin L, Rogers W, Rish N, Honda Y, Qui X, Lin X, Grumet FC, Fernandez-Vina M, Tokunaga K, Miki T, Hsu S and Leffell MS:  Complex HLA-DR and DQ interaction confer risk for narcolepsy in three ethnic groups.  American Journal of Human Genetics, 68: 686-99, 2001.

Dunn TA, Iglehart BA and Leffell MS:  Identification of a Novel DR4 Allele, DRB1*0442.  Tissue Antigens 58:198-00, 2001.

Leffell MS:  Immunogenetic advances that may impact hematopoietic stem cell transplantation: Report from the October 13-17, 2001 meeting of the American Society for Histocompatibility and Immunogenetics. International Society for Hamatotherapy and Graft Engineering Telegraft. 8:9-12, 2001.

Brodsky RA, Fuller AK, Ratner LE, Leffell MS and Jones RJElimination of Alloantibodies by immunoablative high-dose cyclophosphamide.  Transplantation, 71:482-84, 2001.

Miura Y, Thoburn CJ, Bright EC, Sommer M, Leffell MS, Ueda M, Nakao S and Hess AD: Characterization of the T-cell repertoire in autologous graft-versus-host disease (GVHD): evidence for the involvement of antigen-driven T-cell response in the development of autologous GVHD.  Blood 98(3):868-876, 2001.

Leffell MS:  MHC Polymorphism: Coping with the Allele Explosion. Clinical and Applied Immunology Reviews 3:35-46, 2002.

Leffell MS: Pre-Transplant Monitoring: Summary of presentations.  In, Visuals of Clinical Histocompatibility Workshop (P.I. Terasaki, ed). One Lambda, Inc., Cancun Mexico, 2002, pp.1-2.

Zachary AA, Schillinger K, Lucas DP and Leffell MS:  The effect of low level antigen expression on rejection and tolerance.  In, Visuals of clinical Histocompatibility Workshop (P.I. Terasaki, ed).  One Lambda, Inc., Cancun Mexico, 2002, pp.25-26.

Zachary AA, Kopchaliiska D, Lucas, DP, Graziani JA and Leffell MS:  Specific down-regulation of antibody to donor HLA.  In, Visuals of Clinical Histocompatibility Workshop (P.I. Terasaki, ed).  One Lambda, Inc., Cancun, Mexico, 2002, pp. 23-24.

Leffell MS, Delaney NL, Lucas DP and Zachary AA:  Differences in cytokine expression allele frequencies between African Americans and Caucasians.  In, Visuals of Clinical Histocompatibility Workshop (P.I. Terasaki, ed).  One Lambda, Inc., Cancun, Mexico, 2002, pp. 99-100.

Leffell MS, Fallin MD, Erlich HA, Fernandez-Viña M, Hildebrand WH, Mack SJ and Zachary AA:  HLA Antigens, Alleles and Haplotypes Among the Yup’ik Alaska Natives.  Report of the ASHI Minority Workshops: Part II.   Human Immunology 63: 614-25, 2002.

O’Donnell PV, Luznik L, Jones RJ, Vogelsang GB, Leffell MS, Phelps M, Rhubart P, Cowan K, Piantadosi S and Fuchs EJ: Nonmyeloablative Bone Marrow Transplantation from Partially HLA-Mismatched Related Donors Using Post-Transplantation Cyclophosphamide.  Biol Blood Marrow Transplant 8(7):377-86, 2002.

Maiers M, Hurley CK, Perlee L, Fernandez-Vina M, Baisch J, Cook D, Fraser P, Heine U, Hsu S, Leffell MS, Mauer D, Noreen H, Tang T, Trucco M, Yang SY, Yu N, Hartzman RJ, Stterholm M, Winden T, Shepherd D and Hegland J:  Maintaining updated DNA-based HLA assignments in the National Marrow Donor Program Bone Marrow Registry.  Rev Immunogenetics 2: 449-460, 2002.

Zachary AA, Montgomery RA, Ratner LE, Samaniego-Picota M, Kopchaliiska D and Leffell MS:  Specific and durable elimination of antibody to donor HLA antigens in renal transplant patients.  Accepted for publication, Transplantation, 2003.

Leffell MS, Fallin MD, Hildebrand WH, Cavett JW, Iglehart BA and Zachary AA:  HLA Alleles and Haplotypes Among the Lakota Sioux:  Report of the ASHI Minority Workshops:  Part III.  Submission to Human Immunology pending receipt of approval from Lakota Sioux Tribal Council. 

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