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T32 Training Program in Hematology

Selected Publications from Recent T32 Trainees

Pu JJ, Mukhina G, Wang H, Savage WJ, Brodsky RA. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia. Eur J Haematol. 2011 Jul;87(1):37-45. PubMed PMID: 21447004; PubMed Central PMCID: PMC3120909.

Hubbi ME, Luo W, Baek JH, Semenza GL. MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1. Mol Cell. 2011 Jun 10;42(5):700-12. PubMed PMID: 21658608; PubMed Central PMCID: PMC3131976.

Pu JJ, Brodsky RA. Paroxysmal nocturnal hemoglobinuria from bench to bedside. Clin Transl Sci. 2011 Jun;4(3):219-24. PubMed PMID: 21707954; PubMed Central PMCID: PMC3128433.

Choi SM, Liu H, Chaudhari P, Kim Y, Cheng L, Feng J, Sharkis S, Ye Z, Jang YY. Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells. Blood. 2011 May 31. PubMed PMID: 21628406.

Broxmeyer HE, Lee MR, Hangoc G, Cooper S, Prasain N, Kim YJ, Mallett C, Ye Z, Witting S, Cornetta K, Cheng L, Yoder MC. Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood. Blood. 2011 May 5;117(18):4773-7. PubMed PMID: 21393480; PubMed Central PMCID: PMC3100689.

Jang YY, Ye Z, Cheng L. Molecular imaging and stem cell research. Mol Imaging. 2011 Apr;10(2):111-22. PubMed PMID: 21439256.

Chou BK, Mali P, Huang X, Ye Z, Dowey SN, Resar LM, Zou C, Zhang YA, Tong J, Cheng L. Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res. 2011 Mar;21(3):518-29. PubMed PMID: 21243013.

Gerber JM, Qin L, Kowalski J, Smith BD, Griffin CA, Vala MS, Collector MI, Perkins B, Zahurak M, Matsui W, Gocke CD, Sharkis SJ, Levitsky HI, Jones RJ. Characterization of chronic myeloid leukemia stem cells. Am J Hematol. 2011 Jan;86(1):31-7. PubMed PMID: 21132730; PubMed Central PMCID: PMC3010878.

Ross AE, Emadi A, Marchionni L, Hurley PJ, Simons BW, Schaeffer EM, Vuica-Ross M. Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity. BJU Int. 2010 Dec 22. PubMed PMID: 21176082.

Emadi A, Gore SD. Arsenic trioxide - An old drug rediscovered. Blood Rev. 2010 Jul-Sep;24(4-5):191-9. Review. PubMed PMID: 20471733; PubMed Central PMCID: PMC2918685.

Ye Z, Cheng L. Potential of human induced pluripotent stem cells derived from blood and other postnatal cell types. Regen Med. 2010 Jul;5(4):521-30. Review. PubMed PMID: 20632856.

Emadi A, Ross AE, Cowan KM, Fortenberry YM, Vuica-Ross M. A chemical genetic screen for modulators of asymmetrical 2,2'-dimeric naphthoquinones cytotoxicity in yeast. PLoS One. 2010 May 26;5(5):e10846. PubMed PMID: 20520766; PubMed Central PMCID: PMC2877097.

Liu H, Ye Z, Kim Y, Sharkis S, Jang YY. Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology. 2010 May;51(5):1810-9. PubMed PMID: 20432258; PubMed Central PMCID: PMC2925460.Antonarakis ES, Emadi A. Ruthenium-based chemotherapeutics: are they ready for prime time? Cancer Chemother Pharmacol. 2010 May;66(1):1-9. Epub 2010 Mar 6. Review. PubMed PMID: 20213076.

Emadi A, Crim MT, Brotman DJ, Necochea AJ, Samal L, Wilson LM, Bass EB, Segal JB. Analytic validity of genetic tests to identify factor V Leiden and prothrombin G20210A. Am J Hematol. 2010 Apr;85(4):264-70. Review. PubMed PMID: 20162544.

Antonarakis ES, Emadi A. Ruthenium-based chemotherapeutics: are they ready for prime time? Cancer Chemother Pharmacol. 2010 May;66(1):1-9. Epub 2010 Mar 6. Review. PubMed PMID: 20213076.

Mali P, Ye Z, Chou BK, Yen J, Cheng L. An improved method for generating and identifying human induced pluripotent stem cells. Methods Mol Biol. 2010;636:191-205. PubMed PMID: 20336524.

Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. PubMed PMID: 20201064; PubMed Central PMCID: PMC3015217.

Zhan H, Streiff MB, King KE, Segal JB. Thrombotic thrombocytopenic purpura at the Johns Hopkins Hospital from 1992 to 2008: clinical outcomes and risk factors for relapse. Transfusion. 2010 Apr;50(4):868-74. PubMed PMID: 20003052.

Zhan H, Zheng H, Moliterno AR, Streiff MB. Acute cardiomyopathy in a patient with thrombotic thrombocytopenic purpura. Am J Med. 2010 Feb;123(2):e3-4. PubMed PMID: 20103008.

Hristov AC, Cope L, Di Cello F, Reyes MD, Singh M, Hillion JA, Belton A, Joseph B, Schuldenfrei A, Iacobuzio-Donahue CA, Maitra A, Resar LM. HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010 Jan;23(1):98-104. PubMed PMID: 19820691; PubMed Central PMCID: PMC3092591.

Ye Z, Zhan H, Mali P, Dowey S, Williams DM, Jang YY, Dang CV, Spivak JL, Moliterno AR, Cheng L. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood. 2009 Dec 24;114(27):5473-80. PubMed PMID: 19797525; PubMed Central PMCID: PMC2798863.

Emadi A, Jones RJ, Brodsky RA. Cyclophosphamide and cancer: golden anniversary. Nat Rev Clin Oncol. 2009 Nov;6(11):638-47.�Review. PubMed PMID: 19786984.

Hillion J, Wood LJ, Mukherjee M, Bhattacharya R, Di Cello F, Kowalski J, Elbahloul O, Segal J, Poirier J, Rudin CM, Dhara S, Belton A, Joseph B, Zucker S, Resar LM. Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Mol Cancer Res. 2009 Nov;7(11):1803-12.�PubMed PMID: 19903768; PubMed Central PMCID: PMC3069640.

Emadi A, Brodsky RA. Successful discontinuation of anticoagulation following eculizumab administration in paroxysmal nocturnal hemoglobinuria. Am J Hematol. 2009 Oct;84(10):699-701. PubMed PMID: 19705437.

Zou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH, Daley GQ, Porteus MH, Joung JK, Cheng L. Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell. 2009 Jul 2;5(1):97-110. PubMed PMID: 19540188; PubMed Central PMCID: PMC2720132.

Segal JB, Brotman DJ, Emadi A, Necochea AJ, Samal L, Wilson LM, Crim MT, Bass EB. Outcomes of genetic testing in adults with a history of venous thromboembolism. Evid Rep Technol Assess (Full Rep). 2009 Jun;(180):1-162. Review. PubMed PMID: 20629476.

Segal JB, Brotman DJ, Necochea AJ, Emadi A, Samal L, Wilson LM, Crim MT, Bass EB. Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review. JAMA. 2009 Jun 17;301(23):2472-85. Review. PubMed PMID: 19531787.

Jones RJ, Gocke CD, Kasamon YL, Miller CB, Perkins B, Barber JP, Vala MS, Gerber JM, Gellert LL, Siedner M, Lemas MV, Brennan S, Ambinder RF, Matsui W. Circulating clonotypic B cells in classic Hodgkin lymphoma. Blood. 2009 Jun 4;113(23):5920-6. PubMed PMID: 19188663; PubMed Central PMCID: PMC2700327.

Ghosh N, Emadi A. From orbital hybridization to chemotherapeutics neutralization. Blood. 2009 Jun 11;113(24):6262. PubMed PMID: 19520822.

Zhan H, Spivak JL. The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era. Clin Adv Hematol Oncol. 2009 May;7(5):334-42. Review. PubMed PMID: 19521323.

Emadi A, Spivak JL. Anagrelide: 20 years later. Expert Rev Anticancer Ther. 2009 Jan;9(1):37-50. Review. PubMed PMID: 19105705.

Savage WJ, Barber JP, Mukhina GL, Hu R, Chen G, Matsui W, Thoburn C, Hess AD, Cheng L, Jones RJ, Brodsky RA. Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH. Exp Hematol. 2009 Jan;37(1):42-51. PubMed PMID: 19013003; PubMed Central PMCID: PMC2628761.

Hillion J, Dhara S, Sumter TF, Mukherjee M, Di Cello F, Belton A, Turkson J, Jaganathan S, Cheng L, Ye Z, Jove R, Aplan P, Lin YW, Wertzler K, Reeves R, Elbahlouh O, Kowalski J, Bhattacharya R, Resar LM. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? Cancer Res. 2008 Dec 15;68(24):10121-7. PubMed PMID: 19074878; PubMed Central PMCID: PMC2913892.

Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L. Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem. 2008 Sep 5;283(36):24991-5002. Epub 2008 Jul 2. PubMed PMID: 18596037; PubMed Central PMCID: PMC2529127.

Mali P, Ye Z, Hommond HH, Yu X, Lin J, Chen G, Zou J, Cheng L. Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008 Aug;26(8):1998-2005. PubMed PMID: 18511599.

Emadi A, Burns KH, Confer B, Borowitz MJ, Streiff MB. Hematological manifestations of nephropathic cystinosis. Acta Haematol. 2008;119(3):169-72. Epub 2008 May 21. PubMed PMID: 18493119.

Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L. Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Cell Stem Cell. 2008 May 8;2(5):461-71. PubMed PMID: 18462696; PubMed Central PMCID: PMC2442567.

Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L. Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell. 2008 Apr 10;2(4):345-55. PubMed PMID: 18397754; PubMed Central PMCID: PMC2442565.

Each publication, press release or other document that cites results from NIH grant-supported research must include an acknowledgment of NIH grant support and disclaimer such as “The project described was supported by Award Number T32HL007525 from the National Heart, Lung, And Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, And Blood Institute or the National Institutes of Health.

 

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