Director, Anticoagulation Management Service and Outpatient Clinic
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Clinical/Academic Interests
Treatment and prevention of venous thromboembolism, Management of Hemophilia and other coagulation disorders
Research Interests
Dr. Streiff’s major clinical research involves the study of coagulation disorders with a particular interest in the management of venous thromboembolism. He has written several comprehensive reviews on vena caval filters and served on international consensus panels to develop standardized guidelines for the use of vena caval filters in the management of venous thromboembolism. As a member of a Johns Hopkins Evidence-Based Practice Center panel, he participated in the development of evidence reports on the management of venous thromboembolism. His research on patients with malignant gliomas identified ABO blood group as a novel risk factor for VTE in this population. A multicenter clinical trial is now underway to corroborate these results and identify plasma markers of increased risk for venous thromboembolism in glioma patients. As Medical Director of the Anticoagulation Management Service and Outpatient Clinic, he and his colleagues are actively involved in institutional efforts to improve anticoagulation management and safety and refine guidelines for DVT prevention. As the consulting Hematologist for the Johns Hopkins Comprehensive Hemophilia Treatment Center, he is actively involved in the diagnosis and treatment of patients with hemophilia, von Willebrand disease and other hemostatic disorders.
| 1979-83 | B.S., Biology, Washington and Lee University, Lexington, Virginia |
| 1983-84 | Fulbright Scholar, University of Ulm, Ulm, Germany |
| 1984-88 | M.D., Johns Hopkins University, Baltimore, Maryland |
| 1988-91 | Internship and Residency in Medicine, University of Florida, Gainesville, Florida |
| 1991-97 | Post-doctoral Fellow, Hematology/Oncology, Johns Hopkins University, Baltimore, Maryland |
| 1997-2000 | Instructor in Medicine, Johns Hopkins University, Baltimore, Maryland |
| 2000-present | Assistant Professor in Medicine, Johns Hopkins University, Baltimore, Maryland |
Selected Publications
- Streiff, M.B. Vena Caval Filters: A Comprehensive Review. Blood 2000; 95: 3669-3677.
- Arai S. Allan C, Streiff M, Hutchins GM Vogelsang GB, Tsai H-M. Von Willebrand factor-cleaving protease activity and proteolysis of von Willebrand factor in bone marrow transplant-associated thrombotic microangiopathy. Hematol J 2001; 2:292-299.
- Streiff MB, Spivak JL. The diagnosis and management of polycythemia vera in the post-polycythemia vera study group era: A survey of American Society of Hematology (ASH) members’ practice patterns Blood 2002; 99:1144-1149.
- Streiff MB, Ness PM. Acquired factor V inhibitors: a needless iatrogenic complication of bovine thrombin exposure. Transfusion 2002 ;42: 18-26.
- Streiff MB, Mehta S, Thomas DL. Peripheral blood count abnormalities among persons with hepatitis C in the United States. Hepatology 2002; 35:947-952.
- Streiff, MB. Vena caval filters: A Review for Intensive Care Specialists. Journal of Intensive Care Medicine 2003;18:59-79.
- Segal JB, Eng J, Jenckes MW, Tamariz LJ, Bolger DT, Krishnan JA, Streiff MB, Harris KA, Feuerstein CJ, Bass EB. Diagnosis and treatment of deep venous thrombosis and pulmonary embolism. Evid Rep Technol Assess (Summ) 2003 Jan (68):1-6.
- Segal JB, Bolger DT, Jenckes MW, Krishnan JA, Streiff MB, Eng J, Tamariz LJ, Bass EB. Outpatient therapy with low molecular weight heparin for treatment of venous thromboembolism: a systematic review of efficacy, safety and costs. Am J Med 2003 115:298-308.
- Eng J, Krishnan JA, Segal JB, Bolger DT, Tamariz LJ, Streiff MB, Jenckes MW, Bass EB. Accuracy of computed tomography in the diagnosis of pulmonary embolism: a systematic literature review. Am J Roentgen 2004; 183:1819-1827.
- Tamariz LJ, Eng J, Segal JB, Krishnan JA, Bolger DT, Streiff MB, Jenckes MW, Bass EB. Usefulness of clinical prediction rules for the diagnosis of venous thromboembolism: a systematic review. Am J Med 2004 ;117:767-84.
- Streiff MB, Segal J, Grossman SA, Kickler TS, Weir EG. ABO blood group is a potent risk factor for venous thromboembolism in patients with malignant gliomas. Cancer 2004; 100:1717-1723
- Krishnan JA, Segal JB, Streiff MB, Bolger DT, Eng J, Jenckes MW, Tamariz LJ, Bass EB. Treatment of Venous Thromboembolism with Low Molecular Weight Heparin:A Synthesis of the Evidence Published in Systematic Literature Reviews. Respiratory Medicine 2004 98:376-86.
- Buchowski JM, Cascio BM, Streiff MB, Frassica FJ. Resection and Reconstruction of a Massive Femoral Hemophilic Pseudotumor. Clin Ortho Relat Res 2005;430:237-42.
- Hann CL, Streiff MB. The role vena caval filters in the management of venous thromboembolism. Blood Reviews 2005;19:179-202
- Kim HS, Patra A, Paxton BE, Khan J, Streiff MB. Adjunctive Percutaneous Mechanical Thrombectomy For Lower Extremity Deep Vein Thrombosis: Clinical And Economic Outcomes. JVIR 2006 ;17:1099-1104.
- Kim HS, Patra A, Paxton BE, Khan J, Streiff MB. Catheter-Directed Thrombolysis with Percutaneous Rheolytic Thrombectomy vs. Thrombolysis alone in Upper and Lower Extremity DVT. CVIR 2006 Sept (epub ahead of print)
- Gerber DE, Salhotra A, Segal JB, Olivi A, Streiff MB. Venous thromboembolism occurs rarely in post-operative meningioma patients receiving combined modality prophylaxis. Cancer 2007; 109:300-305.
