Director, Transfusion Medicine
Professor, Pathology, Medicine & Oncology
Administrative Office: | 600 N. Wolfe Street |
Clinical/Academic Interests
Transfusion Medicine, AIHA, Therapeutic Apheresis
Research Interests
In recent years, our laboratory has emphasized development of assays for
detecting red cell antibodies and small populations of heterogeneous red
cells using a quantitative enzyme-linked antiglobulin test. This assay has
proved useful in the study of fetal-maternal hemorrhage, red cell survival
studies, and autoimmune hemolytic anemia. We have also studied the
pathophysiology of delayed hemolytic transfusion reactions using a
rabbit model and are undertaking studies of red cell alloimmunization
in mice. Ongoing clinical studies in transfusion medicine include the
use of hemodilution in elective surgery, assessment of the risk of viral
and bacterial infections in blood recipients, research on the recurrence
of cancer as related to the immunosuppressive effects of blood
transfusions, and the development and use of hemoglobin-based oxygen
carriers as blood substitutes.
| 1963-1967 | Massachusetts Institute of Technology, S.B. in Life Sciences |
1967-1971 | State University of New York at Buffalo |
| 1971-1972 | Intern in Medicine, SUNY at Buffalo |
1972-1974 | Staff Associate, Division of Blood Diseases and Resources; National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland. |
1974-1975 | Resident in Medicine, The Johns Hopkins Hospital Baltimore, Maryland. |
1975-1977 | Fellow in Hematology-Oncology, University of California San Francisco, California. |
1973-1974 | Clinical Instructor, Department of Medicine, George Washington University, Washington, D.C. |
1977-1979 | Clinical Assistant Professor in Medicine, University of California, San Francisco, California. |
1979-Present | Medical Director, Blood Bank and Transfusion Service, The Johns Hopkins Hospital, Baltimore, Maryland. |
1979-1982 | Assistant Professor, Pathology and Medicine, The Johns Hopkins University, Baltimore, Maryland. |
1983-2000 | Director, Blood Services, Chesapeake Region Red Cross, Baltimore, Maryland |
1982-1995 | Associate Professor, Pathology and Medicine, The Johns Hopkins University, Baltimore, Maryland |
1995-Present | Professor, Pathology and Medicine, The Johns Hopkins University Baltimore, Maryland |
Selected Publications
- Conley, C.L., Lippman, S.M., Ness, P.M., Johnson, R.J., Petz, L.D. Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow. N. Engl. J. Med. 306:281, 1982.
- Ness, P.M. The assessment of fetal maternal hemorrhage by an enzyme linked antiglobulin test for Rh Immune Globulin recipients. Am J. Ob. Gyn. 143:788, 1982.
- Ness P.M., Shirey R.S., Thoman S.A., Buck S.A. The differentiation of delayed serologic hemolytic transfusion reactions: incidence, long-term serologic findings, and clinical significance. Transfusion 30:688-693, 1990.
- Ness, P.M., Douglas, D.K., Koziol, D.E., Harper, M.C., Munoz, A., Polk, B.F. Decreasing seroprevalence of human immunodeficiency virus (HIV-I) in a regional blood donor population. Transfusion 30:201-206, 1990.
- Bell W.R., Braine H.G., Ness P.M., Kickler T.S. Improved survival in thrombotic thrombocytopenic purpura - hemolytic uremic syndrome. N Engl J Med 325:398-403, 1991.
- Ness P.M., Walsh P.C., Zahurak M., Baldwin M.L., Piantadosi S. Prostate cancer recurrence in radical surgery patients receiving autologous or homologous blood. Transfusion 32: 31-36, 1992.
- Gould SA, Moore EE, Hoyt DB, Ness PM, Norris EJ, Carson JL, Hides GA, Freeman IHG, DeWoskin R, Moss GS. The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. J Am Coll Surg 195; 445-455, 2002.
- Buetens OW, Ness PM. Red blood cell transfusion in autoimmune hemolytic anemia. Current Opinion in Hematology 10:429-433.
- Ness PM, Kruskall MS. Principles of Red Blood Cell Transfusion, in Hematology; Basic Principle and Procedure, Hoffman K, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LJ, McGlave P, eds. Churchill.II Livingston, New York. Pp 2423-2432, 2005
- Anderson, K.C., Ness, P.M. Scientific Basis of Transfusion Medicine: Implications for Clinical Practice. Second Edition W.B. Saunders, Philadelphia, PA. 1999.
