CHARLES STEVEN HESDORFFER, MBBCh, MMED(Wits), FCP(SA)
Associate Professor of Medicine and Oncology
Director, Division of Hematology at Bayview
To Make an Appointment:
Dr. Charles Hesdorffer is located at Johns Hopkins Bayview Medical Center
New Patients: 410-550-1711 choose option 3
Return Patients: 410-550-1711 choose option 4
Administrative Office: 410-550-5050
fax: 410-550-0662
Education and Professional Experience:
Medical School, graduated in 1978:
University of the Witwatersrand, Johannesburg South Africa
Internship/Residency/Instructor (1979-1986):
Johannesburg Teaching Hospitals (under Professor T.H. Bothwell)
Hematology/Oncology Fellowship (1986 – 1989):
Columbia University in New York City
Faculty (1989-2005):
Professor of Clinical Medicine and Surgery at Columbia University in New York
Professional Organizations and Societies:
Medical Council of Great Britain
College of Physicians of South Africa
International Society for Cellular Therapy
American Society for Blood and Marrow Transplantation
American Society of Clinical Oncology
American Society of Hematology
American Medical Association
New York Cancer Society
American Society of Gene Therapy
American College of Physicians
European Society of Medical Oncology
European Society of Gene Therapy
The Society of the Study of Blood, Inc.
Society for Neuro-Oncology
American Association for the Advancement of Science
New York Academy of Sciences
HONORS AND AWARDS:
Jock Gear Memorial Prize - University of the Witwatersrand Medical School.
Gene Therapy Award - Columbia University.
Junior Faculty Teacher of the Year - Columbia University
Invited Guest Speaker, United Nations Environmental Protection Agency
National Leadership Award, Honorary Co-Chairman, Physicians Advisory Board in New York State
New York Magazine – Best Doctors in New York
Best Doctors in the NY Metropolitan Region, Castle Connolly Medical Ltd.
Best Doctors in America, Castle Connolly Medical Ltd.
Best Cancer Doctors in America, Castle Connolly Medical Ltd
Clinical and Research Interests:
Chronic Lymphocytic Leukemia (CLL)
Low grade lymphoma
Cutaneous T-cell Lymphoma
Primary Central Nervous System Lymphoma
Marrow Failure especially myelodysplasia
Benign Plasma Cell Syndromes – primary light chain amyloid, POEMS
Thrombotic Thrombocytopenic Purpura (TTP)
Selection of Recent Publications:
Kumar KS, Lefkowitch J, Russo MW, Hesdorffer C, Kinkhabwala M, Kapur S, Emond JC, Brown JS Jr. Successful sequential liver and stem cell transplantation for hepatic failure due to Primary AL Amyloidosis. Gastroenterology, 7:2026-31, 2002.
Nichols G, deCastro K, Wei L-X, Griffin M, Lin N, Oratzi A, Murty V, Vahdat L, and Hesdorffer C. Therapy-related myelodysplastic syndrome after autologous transplantation for breast cancer. Leukemia Res., 9:1673-9, 2002.
Dutoit V, Taub RN, Papadopoulos KP, Talbot S, , Keohan M-L , Brehm M, Gnjatic S, Harris PE, Bisikirska B, Guillame P, Cerottini J-C, Hesdorffer CS, Old L and Valmori D. Multi-epitope CD8+ T-cell response to a NY-ESO-1 peptide vaccine results in unfocussed tumor reactivity. JCI, 110:1813-1822, 2002.
Danila Valmori, Maha Ayyoub, Charles S. Hesdorffer, Ulrich Keilholz, Carmen Scheibenbogen. A monoclonal melanoma-specific T cell population phenotypically indistinguishable from CD3+ LGL-leukemia. Blood 101:4643-4, 2003.
Maha Ayyoub, Charles S. Hesdorffer, Genevieve Metthez, StefanStefanovic, Gerd Ritter, Lloyd J. Old, Danile Speiser, Jean-Charles Cerotinni, Danila Valmori. Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells. J. of Immunol. 172:7206-11, 2003.
Amy Tiersten, Jennifer Wo, Caron Jacobson, Aaron Weitzman, Tamara Horwich, Charles Hesdorffer, David Savage, Andrea Troxel. Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer. Breast, 13:341-346, 2004
Maha Ayyoub, Charles S. Hesdorffer, Monica Montes, Andrea Merlo, Daniel Speiser, Donata Rimoldi, Jean-Charles Cerottini, Gerd Ritter, Mathew Scanlan, Lloyd J. Old, Danila Valmori. An Immunodominant SSX-2-derived epitope recognized by CD4+ T cells in association with HLA-DR. JCI, 113:1225-1233, 2004.
Maha Ayyoub, Robert N. Taub, Mary-Louise Keohan, Mary Hesdorffer, Genevieve Metthez, Lorenzo Memeo, Mahesh Mansukhani, Hanina Hibshoosh, Charles S. Hesdorffer, Danila Valmori. The frequent expression of cancer/testis antigens provides opportunities for immunotherapeutic targeting of sarcoma. Cancer Immunity, 4:7-20, 2004.
Stubblefield MD. Vahdat LT. Balmaceda C, Troxel AB, Hesdorffer CS, Gooch CL. Glutamine, as a Neuroprotective Agent in High-dose Paclitaxel-induced Peripheral Neuropathy: A Clinical and Electrophysiologic Study. Clin. Oncology 17:271-276, 2005.
Danila Valmori, Andrea Merlo, Naira E. Souleimanian, Charles S. Hesdorffer, Maha Ayyoub. A peripheral circulating compartment of Natural naïve CD4+ Tregs. JCI, 115:1953-1962, 2005.
Danila Valmori, Naira E. Souleimanian, Charles S. Hesdorffer, Lloyd J. Old, Maha Ayyoub. Quantitative and qualitative assessment of circulating NY-ESO-1 specific CD4+ T cells in cancer free individuals. Clin. Immunol. 117:161-7, 2005.
Maha Ayyoub, Naira E. Souleimanian, Emmanuelle Godefroy, Luigi Scotto, Charles S. Hesdorffer, Loyd Old, Danila Valmori. A phenotype based approach for the immune monitoring of NY-ESO-1-specific CD4+ T cell responses in cancer patients. Clin. Immunol. 118:188-94, 2006
Cesana GC, DeRaffele G, Cohen S, Moroziewicz D, Mitcham J, Stoutenburg J, Cheung K, Hesdorffer C, Kim-Schulze S, Kaufman HL. Characterization of CD4+CD25+ regulatory T-cells in patients treated with high-dose interleukin-2 for metastatic melanoma and renal cell carcinoma. JCO, 24:1169-77, 2006.
Hirano M, Marti R, Casali C, Tadesse S, Uldrick T, Fine B, Escolar DM, Valentino ML, Nishino I, Hesdorffer C, Schwartz J, Hawks RG, Martone DL, Cairo MS, Dimauro S, Stanzani M, Garvin JH Jr, Savage DG. Allogeneic stem cell transplantation corrects biochemical derangements in MNGIE. Neurology, 67:1-1, 2006.
Maurer MS, Raina A, Hesdorffer C, Bijou R, Colombo P, Deng M, Haythe J, Horn E, Lee SH, Marboe C, Naka Y, Radhakrishnan R, Restaino S, Mancini D. Cardiac Transplantation using Extended-donor Criteria Organs for Systemic Amyloidosis complicated by Heart Failure. Transplantation 83:539-45, 2007.
Valmori D, Levy F, Godefroy E, Scotto L, Souleimanian NE, Karbach J, Tosello V, Hesdorffer C, Old LJ, Jager E, Ayyoub M. Epitope clustering in regions undergoing efficient proteasomal processing defines immunodominant CTL regions of a tumor antigen. Clin. Immunology, 122:163-72, 2007.
