Director, Division of Hematology
Professor of Medicine and Oncology
Edythe Harris Lucas and Clara Lucas Lynn Chair in Hematology
TO MAKE AN APPOINTMENT:
New Patients: 410-955-8964
Return Patients: 410-955-8895
Administrative Office: 410-502-2546
fax: 410-955-0185
Clinical/Academic Interests:
Aplastic Anemia, PNH and Other Bone Marrow Failure Disorders
Research Interests:
Dr. Brodsky’s major clinical research involves the study of aplastic anemia, PNH and other bone marrow failure disorders. His research shows that immunoablative doses of cyclophosphamide, without bone marrow transplantation, can lead to durable complete remissions in severe aplastic anemia. The reason high-dose cyclophosphamide is able to ablate the effector cells without destroying hematopoietic stem cells is that the earliest stem cells (but not lymphocytes) contain high levels of aldehyde dehydrogenase conferring resistance to the cytotoxic properties of cyclophosphamide. Dr. Brodsky and his colleagues in neurology and rheumatology are applying this approach in other severe autoimmune disorders including, scleroderma, myasthenia gravis, multiple sclerosis and autoimmune hematologic disorders.
Laboratory Interests:
Dr. Brodsky’s major laboratory interests relate to the study of normal and abnormal hematopoiesis. Specifically his lab studies PIG-A gene mutations in PNH and aplastic anemia. His group has developed a novel diagnostic assay for PNH based on the pore forming toxin (aeromonas hydrophila).
Education/Training:
1982-1985 B.A., Political Science, University of Pennsylvania, Philadelphia, Pennsylvania
1985-1989 M.D., Hahnemann University, Philadelphia, Pennsylvania
1989-1991 Internship and Residency in Medicine, Vanderbilt University, Nashville, Tennessee
1991-1993 Medical Staff Fellow, Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
1993-1994 Hematology Fellowship, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
1994-1997 Oncology Fellowship, Johns Hopkins University, Baltimore, Maryland
Academic Positions:
1997-1998 Instructor in Oncology and Medicine, Johns Hopkins University, Baltimore, Maryland
1998-2002 Assistant Professor in Oncology and Medicine, Johns Hopkins University, Baltimore, Maryland
2002-2009 Associate Professor in Medicine and Oncology, Johns Hopkins University, Baltimore, Maryland
2009-Present Professor of Medicine and Oncology, Johns Hopkins University, Baltimore, Maryland
Selected References
- Brodsky, R.A., Sensenbrenner L.L., Jones, R.J. Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation. Blood 87:491-494, 1996.
- Brodsky, R.A., Vala, M.S., Barber, J.P., Medof, M.E., Jones, R.J. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Proceedings of the National Academy of Sciences 94:8756-8760, 1997.
- Brodsky, R.A., Petri, M., Smith, B.D, Seifter, E.J., Spivak, J.L., Styler, M., Dang, C.V., Brodsky, I., Jones, R.J. Immunoablative high-dose cyclophosphamide without stem cell rescue for refractory severe autoimmune disease. Annals of Internal Medicine 129:1031-1035, 1998.
- Brodsky, R.A., Mukhina, G.L., Nelson, K.L., Lawrence, T.S., Jones, R.J., Buckley, J.T. Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin. Blood 93: 1749-1756, 1999.
- Brodsky, R.A., Mukhina, G.L., Li, S., Nelson, K.L., Chiurazzi, P.L., Buckley, J.T., Borowitz, M.J. Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin. American Journal of Clinical Pathology 114:457-464, 2000.
- Brodsky, R.A., Sensenbrenner, L.L., Smith, B.D., Dorr, D., Seaman, P.J., Lee, S.M., Karp, J.E., Brodsky, I., Jones, R.J. Durable treatment-free remission following high-dose cyclophosphamide for previously untreated severe aplastic anemia. Annals of Internal Medicine, 135:477-483, 2001.
- Mukhina, G.L., Buckley, J.T., Barber, J.P., Jones, R.J., Brodsky, R.A. Multilineage glycosylphosphatidylinositol deficient haematopoiesis in untreated aplastic anaemia. British Journal of Haematology, 115:476-482, 2001.
- Chen, R., Eshleman, J.R., Brodsky, R.A., Medof, M.E. Glycosylphosphatidylinositol-anchored protein deficiency as a marker of mutator phenotypes in cancer. Cancer Research 61:654-658, 2001.
- Moyo, V.M., Smith, B.D., Brodsky, I., Crilley, P., Jones, R.J., Brodsky, R.A. High-dose cyclophosphamide for refractrory autoimmune hemolytic anemia. Blood, 100:704-706, 2002.
- Drachman, D.B., Jones, R.J., Brodsky, R.A. Treatment of refractory myasthenia gravis: “rebooting” with high dose cyclophosphamide. Annals of Neurology, 53:29-34, 2003.
- Petri, M., Jones, R.J., Brodsky, R.A. High dose cyclophosphamide without stem cell transplantation in systemic lupus erythematosus. Arthritis and Rheumatism, 48:166-173, 2003.
- Moyo, V.M., Mukhina, G.L., Garrett, E.S., Brodsky, R.A. Natural history of paroxysmal nocturnal hemoglobinuria using modern diagnostic assays. Br J Haematol, 126(1):133-8, 2004.
- Brodsky, R.A., Chen, A., Brodsky, I., Jones, R.J. High Dose Cyclophosphamide as Salvage Therapy for Severe Aplastic Anemia. Experimental Hematology, 32:435-440, 2004.
- Hu, R., Mukhina, G.L., Piantadosi, S., Barber, J.P., Jones, R.J., Brodsky, R.A. PIG-A Mutations in Normal Hematopoiesis. Blood, 105:3848-3854, 2005.
- Brodsky, R.A., Jones, R.J. Aplastic anaemia. Lancet, 365:1647-1656, 2005.
- Hillmen, M.B., Young, N.S., Schubert, J., Brodsky, R.A., Socie, G., Muus, P., Roth, A., Szer, J. Elebute, M.O., Nakamura, R., Browne, P., Risitano, A.M., Hill, A., Schrezenmeier, H., Fu, C., Maciejewski, J., Rollins, S.A., Mojcik, C.F., Rother, R.P., Luzzatto, L. Safety and efficacy of the C5 Complement Inhibitor Eculizumab in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006 Sep 21;355:1233-43.
