- Live, attenuated vaccine (LAIV) may be given to healthy adults less than 50 years of age who are not pregnant and who do not have contraindications to receiving the nasal vaccine. Health care personnel taking care of immunocompromised patients may receive LAIV. However, if healthcare personnel who care for severely immunocompromised patients in protected environments receive LAIV, then they should not care for these patients for 7 days following immunization.
- The following persons should not receive LAIV
- persons with a history of hypersensitivity, including anaphylaxis, to any of the components of LAIV or to eggs
- persons 2-4 years old who have recurrent wheezing and healthy persons 50 years and older;
- persons with asthma, reactive airways disease or other chronic disorders of the pulmonary or cardiovascular systems;
- persons with other underlying medical conditions, including such metabolic diseases as diabetes mellitus, renal or hepatic dysfunction and hemoglobinopathies; or persons with known or suspected immunodeficiency diseases or who are receiving immunosuppressive therapies;
- children or adolescents receiving aspirin or other salicylates (because of the association of Reye’s syndrome with wild-type influenza infection)
- persons with a history of Guillain-Barré syndrome;
- pregnant women;
- persons with a fever or significant nasal congestion that may interfere with delivery of the LAIV. (Administration of LAIV should be postponed.); persons with mild respiratory illness can receive LAIV.
