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Heart & Vascular Institute

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Van Eyk Lab Publications

Selected Publications:

  1. Murphy AM, Kogler H, Georgakopoulos D, McDonough JL, Kass DA, Van Eyk JE, Marban E. Transgenic mouse model of stunned myocardium. Science 2000;287:488-491.

  2. Xu W, Liu Y,Wang S, McDonald T, Van Eyk JE, Sidor A, O'Rourke B. Cytoprotective role of the Ca-activated K+ channel in cardiac inner mitochondrial membrane. Science 2002;298: 1029-1033..

  3. Younes A, Lyashkov AE, Graham D, Sheydina A, Volkova MV, Mitsak M, Vinogradova TM, Lukyanenko Yo, Li Y, Ruknudin AM, Boheler KR, Van Eyk JE, Lakatta EG.Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells. J Biol Chem. 2008;283:14461-8.

  4. Mathivanan S et al., Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008;26:164-7.

  5. Schoenhoff FS, Fu Q, Van Eyk JE. Cardiovascular proteomics: implications for clinical applications. Clin Lab Med. 2009;29:87-99.

  6. Stastna M, Abraham MR, Van Eyk JE. Cardiac stem/progenitor cells, secreted proteins, and proteomics. FEBS Lett. 2009,583:1800-7.

  7. Foster DB, Van Eyk JE, Marbán E, O'Rourke B. Redox signaling and protein phosphorylation in mitochondria: progress and prospects. J Bioenerg Biomembr. 2009:41:159-68

  8. Kane LA, Van Eyk JE. Post-translational modifications of ATP synthase in the heart: biology and function. J Bioenerg Biomembr. 2009:41:145-50.

  9. Fu Z, Wang M, Gucek M, Zhang J, Wu J, Jiang L, Monticone RE, Khazan B, Telljohann R, Mattison J,Sheng S, Cole RN, Spinetti G, Pintus G, Liu L, Kolodgie FD, Virmani R, Spurgeon H, Ingram DK, Everett AD, Lakatta E, Van Eyk JE. Milk Fat Globule Protein-Epidermal Growth Factor-8: a Pivotal Relay Element within the Angiotensin II and Monocyte Chemoattractant Protein-1 Signaling Cascade Mediating Vascular Smooth Muscle Cells Invasion, Circ. Res, 2009:104:1337-46.

  10. Murray CI, Barrett M, Van Eyk JE. Assessment of ProteoExtract subcellular fractionation kit reveals limitedand incomplete enrichment of nuclear subproteome from frozen liver and heart tissue. Proteomics 2009:9:3934-8.

  11. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De BackerJ, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC; the GenTAC Consortium. Circulating Transforming Growth Factor-beta in Marfan Syndrome. Circ. 2009:120:526-32.

  12. Editorial: Braverman AC. Transforming Growth Factor-beta. A Biomarker in Marfan Syndrome?

  13. Gao P, Tchernyshyov I, Chang T-C, Lee Y-S, Kita K, Ochi T, Zeller K, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV. c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism. Nature 2009: 458:762-5.

  14. Hesketh GG, Van Eyk JE, Tomaselli GF. Mechanisms of gap junction traffic in health and disease. J Cardiovasc Pharmacol. 2009, in press. Review

  15. Gundry RL, Raginski K, Tarasova Y, Tchernyshyov I, Bausch-Fluck D, Elliott ST, Boheler KR, Van Eyk JE, Wollscheid B. The Mouse C2C12 Myoblast Cell Surface N-Linked Glycoprotein Subproteome. Mol. Cell Prot. 2009: in press.

  16. Hsu K, Chi N, Gucek M, Van Eyk JE, Cole RN, Lin M, Foster DB Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3. Blood 2009: In press

  17. Gundry RL, White MY, Murray CI, Kane LA, Fu Q, Stanley BA, Van Eyk JE. Preparation of protein and peptides for mass spectrometry analysis in a bottom-up proteomic workflow. Current Protocols in Molecular Biology, 2009: In press.


book cover for clinical proteomics showing DNA

J.E. Van Eyk and M. Dunn. Genomic and Proteomic Analysis of Cardiovascular Disease: molecular mechanism, therapeutic targets and diagnostics. Wiley-VCH Publishers, 2003

J.E. Van Eyk and M. Dunn. Clinical Proteomics: from Diagnosis to Therapy, Wiley-VCH Publishers, 2007

Patent Applications:

4 patents, 14 applications in proteomic tools and software and protein biomarkers.