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Heart & Vascular Institute

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Tomaselli Lab Publications

Selected Publications:

  1. Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 111:11-20, 2005.

  2. Rose J, Armoundas AA, DiSilvestre D, Tian YL, Burysek M, Halperin V, O’Rourke B, Kass DA, Marbán E, Tomaselli GF. The molecular basis of altered expression of potassium currents in failing rabbit myocardium. Am J Physiol - Heart 288: 2077-2087, 2005.

  3. Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH. A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.  Mol Pharmacol 67: 424-34, 2005.

  4. Xiong W, Tian Y, DiSilvestre D, Tomaselli GF. Transmural heterogeneity of Na+-Ca2+ exchange: evidence for differential expression in normal and failing hearts. Circ Res 207-9, 2005.

  5. Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, Disilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Molecular mechanisms underlying K+ current down regulation in canine tachycardia-induced heart failure. Am J Physiol 288: H2887-96, 2005.

  6. Shah M, Akar FG, Tomaselli GF. Molecular basis of arrhythmias. Circulation 112: 2517-29 2005.

  7. Gao Z, Xu H, DiSilvestre D, Halperin VL, Tunin R, Tian YL, Yu W, Winslow RL, Tomaselli GF. Transcriptomic profiling of the canine tachycardia-induced heart failure model: Global comparison to human and murine heart failure. J Mol Cell Cardiol 40:76-86, 2006.

  8. Akar FG, Aon MA, Tomaselli GF, O’Rourke B. Mitochondrial origin of postischemic arrhythmias. J Clin Invest 115:3527-35, 2005.

  9. Nazarian S, Bluemke DA, Lardo AC, Zviman MM, Watkins SP, Dickfeld TL, Meininger GR, Rougin A, Calkins HG, Tomaselli GF, Weiss RG, Berger RD, Lima JA, Halperin HR. Magnetic Resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation 112:2821-5, 2005.

  10. Piccini JP, Dalal D, Roguin A, Bomma C, Cheng A, Prakasa K, Dong J, Tichnell C, James C, Russell S, Crosson J, Berger RD, Marine JE, Tomaselli G, Calkins H. Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia. Heart Rhythm 2:1188-94, 2005.

  11. Lickfett L, Calkins H, Nasir K, Dickfeld T, Eldadah Z, Jayam V, Leng C, Tomaselli G, Donahue K, Halperin H, Luderitz B, Berger R. Clinical prediction of cavotricuspid isthmus dependence in patients referred for catheter ablation of "typical" atrial flutter. J Cardiovasc Electrophysiol 16:969-73, 2005.

  12. Bass AS, Tomaselli GF, Bullingham R III, Kinter LB. Drugs effects on ventricular repolarization: A critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices. J Pharmacol Toxicol Methods 52:12-21, 2005.

  13. Kittleson MM, Minhas KM, Irizarry RA, Ye SQ, Edness G, Breton E, Conte JV, Tomaselli G, Garcia JG, Hare JM. Gene expression in giant cell myocarditis: Altered expression of immune response genes. Int J Cardiol 102: 333-40, 2005.

  14. Kittleson MM, Minhas KM, Irizarry RA, Ye SQ, Edness G, Breton E, Conte JV, Tomaselli G, Garcia JG, Hare JM. Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure. Physiol Genomics 21: 299-307, 2005.

  15. Azene EM, Xue T, Marban E, Tomaselli GF, Li RA. Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res 67: 263-73, 2005.

  16. Spragg DD, Akar FG, Helm RH, Tunin RS, Tomaselli GF, Kass DA. Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res 67:77-86, 2005.

  17. Akar FG and Tomaselli GF. Conduction Abnormalities in Nonischemic Dilated Cardiomyopathy: Basic Mechanisms and Arrhythmic Consequences. Trends in CV Medicine 15:259-64, 2005.

  18. Akar FG and Tomaselli GF. Ion Channels as Novel Therapeutic Targets in Heart Failure. Annals of Medicine 37:1-12, 2005.

  19. Tse H-F, Xue T, Lau C-P, Siu C-W, Wang K, Zhang Q-Y, Tomaselli GF, Akar FG, Li RA. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation 114:1000-11, 2006.

  20. Xiong W, Farukhi YZ, Tian Y, DiSilvestre D, Li RA, Tomaselli GF. A conserved ring of charge in mammalian Na channels: A molecular regulator of the outer pore conformation during slow inactivation. J Physiol 576:739-754, 2006.

  21. Tomaselli GF. A failure to adapt: ankyrins in congenital and acquired arrhythmias. Circulation Jan 30;115(4):428-9, 2007.

  22. Armoundas AA, Rose J, Aggarwal R, Stuyvers BD, O’Rourke B, Kass DA, Marbán E, Shorofsky SR, Tomaselli GF, Balke CW. Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol. 292(3):H1607-18, 2007.

  23. Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G, Weiss RG, Marbán E, Tomaselli GF, Lima JA, Wu KC. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation 115:2006-14, 2007.

  24. Fernandes VR, Wu KC, Rosen BD, Schmidt A, Lardo AC, Osman N, Halperin HR, Tomaselli GF, Berger RD, Bluemke DA, Marban E, Lima JA. Enhanced infarct border zone function and altered mechanical activation predict inducibility of monomorphic ventricular tachycardia in patients with ischemic cardiomyopathy. Radiology 245:712-9, 2007.

  25. Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D, Tunin RS, Kass DA, Tomaselli GF. Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 293(2):H1223-H1230, 2007.

  26. Henrikson CA, Spragg DD, Cheng A, Capps M, DeVaughn K, Marine JE, Calkins HG, Tomaselli GF, Berger RD. Evidence for electrical remodeling of the native conduction system with cardiac resynchronization therapy. Pacing Clin Electrophysiol. 30(5):591-5, 2007.

  27. Marine JE, Tomaselli GF, Leng CT. Inappropriate implantable cardioverter-defibrillator discharge associated with a new ventricular tachycardia treatment algorithm. Heart Rhythm. 4(5):655-7, 2007.

  28. Biswas S, Deschênes I, DiSilvestre D, Tian YL, Halperin VL, Tomaselli GF. Calmodulin regulation of NaV1.4 current: Role of binding to the carboxyl terminus. J Gen Physiol. 131:197-209, 2008.

  29. Ouwerkerk R, Bottomley PA, Solaiyappan M, Spooner A, Tomaselli GF, Wu KC, Weiss RG. Tissue sodium concentration is elevated in human myocardial infarction: A quantitative 23NaMRI study. Radiology 248:88-96, 2008.

  30. Chakir K, Daya SK, Tunin RS, Helm RH, Byrne MJ, Liang HY, Lardo AC, Abraham T, Tomaselli GF, Kass DA. Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization. Circulation. 117: 1369-77, 2008.

  31. Deschênes I, Armoundas AA, Jones SP, Tomaselli GF. Post-transcriptional gene silencing of KChIP2 and Na(v)beta1 in neonatal rat cardiac myocytes reveals a functional association between Na and I(to) currents. J Mol Cell Cardiol 45(3):336-46, 2008.

  32. Kostis WJ, Tedford RJ, Miller DL, Schulman SP, Tomaselli GF. Troponin-I elevation in a young man with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Interv Card Electrophysiol Jun;22(1):49-53, 2008.

  33. Wu KC, Weiss RG, Thiemann DR, Kitagawa K, Schmidt A, Dalal D, Lai S, Bluemke DA, Gerstenblith G, Marbán E, Tomaselli GF, Lima JA. Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol. 24;51(25): 2414-21. 2008.

  34. Gao Z, Barth AS, Disilvestre D, Akar FG, Tian Y, Tanskanen A, Kass DA, Winslow RL, Tomaselli GF. Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling. Physiol Genomics 2008 Sept 9 [epub ahead of print].

  35. Nass RD, Aiba T, Tomaselli GF, Akar FG. Mechanisms of Disease: ion channel remodeling in the failing ventricle. Nat Clin Pract Cardiovasc Med. 5:196-207, 2008.

  36. Loscalzo J, Tomaselli GF, Vaughan DE, Walsh RA. Task force 7: training in cardiovascular research. J Am Coll Cardiol 51:380-3, 2008.

  37. Tomaselli GF, Aiba T. LQTS: Better with Age? J Cardiovasc Electrophysiol. 2008.

  38. Josephson ME, Rosen MR, Tomaselli GF. The year in arrhythmias--2007: Part I. Heart Rhythm. 5(5):742-8, 2008.

  39. Josephson ME, Rosen MR, Tomaselli GF. The year in arrhythmias 2007: Part II. Heart Rhythm. 5(6):867-71, 2008.

  40. Aiba T, Barth A, Tomaselli GF. Deciphering gene expression profiling in cardiac resynchronization therapy. J Am Coll Cardiol 50(14):1177, author reply 1177-8, 2008.

  41. Bilchick KC, Dimaano V, Wu KC, Helm RH, Weiss RG, Lima JA, Berger RD, Tomaselli GF, Halperin HR, Kass DA, Abraham T, Lardo AC. Magnetic Resonance imaging myocardial tagging for circumferential mechanical dyssynchrony in heart failure: Prediction of cardiac resynchronization therapy response and comparison to tissue Doppler. J Am Coll Cardiol. Cardiovasc Imaging 1:561-8, 2008.

  42. Aiba T, Hesketh GG, Barth AS, Liu T, Daya SK, Chakir K, Dimaano VL, Abraham T, O’Rourke B, Akar FG, Kass DA, Tomaselli GF. Electrophysiological Consequences of Dyssynchronous Heart Failure and its Restoration by Resynchronization Therapy. Circulation 119:1220-30, 2009.

  43. Chakir K, Daya SK, Tunin RS, Liang H-Y, Abraham T, Lai, EW, Pacak K, Xiao R-P, Tomaselli GF, Kass DA. Mechanisms of Enhanced Beta-adrenergic Reserve From Cardiac Resynchronization Therapy. Circulation 119:1231-40, 2009.

  44. Kao WH, Arking DE, Post WS, Rea TD, Sotoodehnia N, Prineas RJ, Bishe B, Doan BQ, Boerwinkle E, Psaty BM, Tomaselli GF, Coresh J, Siscovick DS, Marban E, Spooner PM, Burke GL, Chakravarti A. Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation 119: 940-51, 2009.

  45. Biswas S, DiSilvestre D, Tian YL, Halperin VL, Tomaselli GF. Latent modulation of cardiac sodium channel inactivation by dual mode calcium regulation. Circ Res 104:870-8, 2009.

  46. Cheng A, Dalal D, Fetics BJ, Angkeow P, Spragg DD, Calkins H, Tomaselli GF, Berger RD. Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease. J Cardiovasc Electrophysiol 20:873-9, 2009.

  47. Yamaghishi T, Xiong W, Kondratiev A, Velez P, Mendez-Fitzwilliam A, Balser JR, Marban E, Tomaselli GF. Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding. Mol Pharm in press 2009.

  48. Nazarian S, Dong J, Tomaselli GF, Marine JE. Profound hypotension due to slow atrioventricular nodal pathway conduction during atrial tachycardia. Pacing Clin Electrophysiol 32:278-80, 2009.

  49. Barth AS, Aiba T, Halperin V, DiSilvestre D, Chakir K, Colantuoni C, Tunin RS, Dimaano VL, Yu W, Abraham TP, Kass DA, Tomaselli GF. Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level. Circulation: Cardiovascular Genetics 2:371-8, 2009.

  50. Hesketh GG, Van Eyk JE, Tomaselli GF. Mechanisms of Gap Junction Traffic in Health and Disease. J Cardiovasc Pharmacol in press 2009.