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Theodore Abraham Lab

 Dr. Theodore Abraham is the director of two labs:

  • Translational Cardiovascular Ultrasound Research Laboratory
    • Central objective: To use ultrasound-based imaging technologies for diagnostic and interventional applications in a variety of cardiac pathologies.
  • Cardiac Mechanics Imaging Laboratory
    • Central objective: To develop and evaluate novel imaging tools that depict regional and global cardiac mechanics. Technologies used include ultrasound, magnetic resonance and computed tomography.

Research for both missions is conducted in in-vitro systems, small or large experimental models and clinical trials.

  • We also provide echocardiography and cardiac mechanics core laboratory support for large multi-center clinical trials. Lab expertise covers the entire gamut of echocardiography including standard 2D & Doppler, transesophageal, 3D/4D, contrast imaging, tissue Doppler, strain and interventional echocardiography.

Funding

  • National Institutes of Health
  • American Heart Association
  • American College of Cardiology
  • American Society of Echocardiography
  • Industry

Members

P.I.:

Theodore P. Abraham, MD, FACC, FASE
Associate Professor of Medicine
Director, Translational Cardiovascular Ultrasound & Cardiac Mechanics Imaging Laboratory
Co-Director, Cardiac Imaging Fellowship Program

 

Post-doctoral fellows:

Veronica Dimaano, MD
Aurelio Pinheiro, MD, PhD
Miguel Santaularia-Tomas, MD
Niels Thue Olsen, MD, PhD
Kristian Eskesen, MD
Fatih Yalcin, MD, FESC (Fulbright Scholar)
Jothi Kanagalingam, MD
Sourabh Verma, MD

Pre-doctoral fellows:

Daniel Bernard
Patrick Eulitt

Technical Staff:

Susan Phillip RCS, FASE
(Administrative Director)
Anne Capriotti, RDCS
(Lead sonographer)
Heather Richardson, RDCS
Rodney Cobb, RDCS

Alumni:

Laurens Tops, MD. PhD
Jacob Abraham, MD
Hsin-Yueh Liang, MD
Kalpana Prakasa, MD
Jianwen Wang, MD, PhD
Karen Modesto, MD
Gabriel Yip, MBChB
Stig Urheim, MD
Sanderson Cauduro, MD
Yasuhiko Takemoto, MD, PhD
Kamran Rizvi, MD
Carl Laskowski, PhD

Projects

Topics of interest include cardiac dyssynchrony, hypertrophic cardiomyopathy, coronary artery disease, strain echocardiography, strain by magnetic resonance imaging, diastolic mechanics and interventional echocardiography.

Publications

  1. Abraham T, Belohlavek M, Thomson H, Pislaru C, Khandheria B, Seward J, Pellikka P. Time to onset of regional relaxation: Feasibility, variability and normal values of a novel index of regional myocardial function by strain rate imaging. J Am Coll Cardiol2002;39(9):1531-1535.

  2. Abraham T, Nishimura R, Holmes D, Jr., Belohlavek M, Seward J. Strain Rate Imaging for Assessment of Regional Myocardial Function: Results from a Clinical Model of Septal Ablation. Circulation 2002;105:1403-1406.

  3. Abraham T, Laskowski C, Zhan W-Z, Belohlavek M, Martin E, Greenleaf JF, Sieck GC. Myocardial Contractility by Strain Echocardiography: Comparison with Physiologic Measurements in an in vitro Model. Am J Physiol 2003;285:H2599-H2604. Yip G, Khandheria B, Belohlavek M, Pislaru C, Pellikka P, Abraham T. Strain Echocardiography Predicts Changes in Regional Myocardial Perfusion During Dobutamine Stress. J Am Coll Cardiol 2004; 44: 1664-71.

  4. Modesto KM, Dispenzieri A, Cauduro SA, Lacy M, Khandheria BK, Pellikka PA, Belohlavek M, Seward JB, Kyle R, Tajik AJ, Gertz M, Abraham TP. Left atrial myopathy in cardiac amyloidosis: implications of novel echocardiographic techniques. Eur H J 2005; 26:173-179..

  5. Wang J, Abraham T, Korinek J, Urheim S, McMahon E, Belohlavek M. Delayed onset of subendocardial diastolic thinning identifies hypoperfused myocardium. Circulation 2005;111:2943-2950.

  6. Takemoto Y, Pellikka P, Modesto K, Cauduro S, Belohlavek M, Seward J, Thomson H, Khandheria B, Abraham T. Analysis of the Interaction between Segmental Relaxation Patterns and Global Diastolic Function by Strain Echocardiography. J Am Soc Echocardiogr 2005; 18:839-843.

  7. Korinek J, Wang J, Sengupta P, Miyazaki C, Kjaergaard J, McMahon E, Abraham T, Belohlavek M. 2D Strain ? A Doppler Independent Ultrasound Method for Quantification of Regional Deformation: Validation in-vitro and in-vivo. J Am Soc Echocardiogr2005; 18: 1247-1253.

  8. Urheim S, Cauduro S, Frantz R, McGoon M, Belohlavek M, Green T, Miller F, Bailey K, Seward J, Tajik J, Abraham T. Tissue Displacement and Strain Correlate with Invasively Determined Right Ventricular Stroke Volume. Am J Cardiol 2005; 96:1173-1178.

  9. Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan J, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM. Cardiac Resynchronization Therapy PART 1 ? Issues before device implantation. J Am Coll Cardiol 2005; 46:2153-2167.

  10. Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan J, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM. Cardiac Resynchronization Therapy PART 2- Issues during and after device implantation and unresolved questions. J Am Coll Cardiol 2005;46:2168-2182.

  11. Lardo A, Abraham TP, Kass DA. Assessment of Ventricular Dyssynchrony: Current Status and Potential Solutions. J Am Coll Cardiol 2005;46:2223-2228.

  12. Liang H-Y, Cauduro SA, Pellikka PA, Bailey KR, Grossardt BR, Yang EH, Rihal C, Seward JB, Miller FA, Abraham TP. Comparison of Usefulness of Echo-Doppler Variables to Left Ventricular End-Diastolic Pressure in Predicting Future Heart Failure Events. Am J Cardiol. 2006 Mar 15;97(6):866-71.

  13. Takemoto Y, Hozumi T, Sugioka K, Takagi Y, Matsumura Y, Yoshiyama M, Abraham TP, Yoshikawa J.Beta-blocker therapy induces ventricular resynchronization in dilated cardiomyopathy with narrow QRS complex. J Am Coll Cardiol. 2007 Feb 20;49(7):778-83.

  14. Chakir K, Daya S, Aiba T, Tunin R, Dimaano V, Abraham TP, Jacques J, Lai E, Pacak K, Zhu W-Z, Xiao R-P, Tomaselli G, Kass D. Mechanisms of Enhanced Beta-adrenergic Reserve From Cardiac Resynchronization Therapy. Circulation 2009 Mar 10;119(9):1231-40.

  15. Abraham TP, Jones M, Liang H-Y, Pinheiro AC, Wagg C, Lopaschuk GD, Szczesna-Cordary D. Diastolic Dysfunction in Transgenic Mice Expressing Cardiac Myosin Regulatory Light Chain R58Q Mutation. Cardiovasc Res (in press).

  16. Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA, Tomaselli GF. Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation. 2009 Mar 10;119(9):1220-30.