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Roselle Abraham Lab

 The Abraham Lab is focused on investigation of hypertrophic cardiomyopathy. Areas of focus include:

1. Role of mitochondria, metabolic/redox alterations in generation of the molecular phenotype in hypertrophic cardiomyopathy.

2. Design of individualized therapies for hypertrophic Cardiomyopathy using mutation-specific induced pluripotent stem cells.

3. Prediction/prevention of arrhythmias in hypertrophic cardiomyopathy.

Funding

Funding sources include AHA, TEDCO, NIH, WW Smith Foundation
 

Members

PI:


Roselle Abraham, MD

Laboratory Members:

Connie Chang, graduate student
Junaid Afzal, graduate student
Vincent Lin, graduate student
Tina Lee, undergraduate student

Laboratory Alumni:

Marvin Chang, graduate student
Michael Bonios, postdoctoral fellow
John Terrovitis, postdoctoral fellow
Amr Youssef, postdoctoral fellow
Linmiao Xu, undergraduate student
Samuel Ghasi, visiting professor

Projects

Methods that we employ include tissue culture, animal surgery, in vivo multimodality molecular imaging, 2-photon microscopy, flow cytometry, protein and gene expression, gene delivery and optical mapping.

Publications

  1. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, O’Rourke B, Marban E. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circulation Research, 2005 Jul 22; 97(2):159-67. Epub 2005 Jun 23

  2. Chang MG, Tung L, Sekar RB, Chang CY, Cysyk J, Dong PH, Marban E, Abraham MR. Proarrhythmic potential of mesechymal stem cells revealed in an in vitro co-culture model. Circulation, 2006 Apr 18; 113(15):1832-41.

  3. Terrovitis J, Stuber M, Youssef A, Preece S, Leppo M, Kizana E, Gerstenblith G, Weiss RG, Marban E, Abraham MR. Magnetic Resonance Imaging Overestimates Ferumoxide-labeled Cardiac Stem Cell Survival Following Transplantation. Circulation, March 25;117(12):1555-62

  4. Chang MG, Zhang Y, Tung L, Chang CY, Marban E, Abraham MR. Reentry dynamics in an in vitro model of the healed infarct borderzone. Circulation Research, In press.

  5. Terrovitis J, Kwok KF, Lautamaki R, Engles JM, Barth A, Miake J, Leppo MK, Fox J, Seidel J, Wahl RL, Tsui B, Bengel F, Marban E, Abraham MR. In vivo Cardiac Stem Cell Tracking by SPECT and PET Imaging Using the Sodium-iodide Symporter as Reporter Gene. J Am Coll Cardiol. 2008 Nov 11;52(20):1652-60.

  6. Barth AS, Kizana E, Terrovitis J, Dong P, Smith RR, Leppo M, Zhang Y, Miake J, Abraham MR, Marban E. Novel lentiviral vectors bearing the cardiac specific promoter of the sodium-calcium exchanger report cardiogenic differentiation in stem cells. Molecular Therapy, 2008 Mar 18 (Epub ahead of print).

  7. Smith RR, Barile L, Cho H, Messina E, Leppo M, Hare J, Giacomello A, Abraham MR, Marban E. Regenerative potential of adult human cardiac stem cells isolated from endomyocardial biopsy specimens. Circulation, 2007 Feb 20;115(7):896-908.

  8. Terrovitis J, Lautamaki R, Bonios M, Fox J, Engles JM, Yu J, Leppo MK, Pomper MG, Wahl RL, Seidel J, Tsui B, Bengel FM, Abraham MR, Marban E. Non-invasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J Am Coll Cardiol, In press.

  9. Stastna M, Abraham MR, Van Eyk JE. Cardiac stem/progenitor cells, secreted proteins and proteomics. FEBS Lett. 2009, Jun 5;583(11):1800-7. Epub 2009 Mar 20.

  10. Bonios M, Terrovitis J, Abraham MR. Stem cell: ‘Kant’ you see it? Journal of Cardiovascular Translational Research, 2008, In press.

  11. Abraham MR, Gerstenblith G. Preconditioning stem cells for cardiovascular disease: An important step forward. Circulation Research, 2007 Mar 2;100(4):447-9

  12. Abraham MR, Hare JM. Is skeletal myoblast transplantation proarrhythmic? The jury is still out. Heart Rhythm, 2006, Apr;3(4):462-3

Awards:

Michael Bonios:
Melvin Judkins Young Investigator Award Finalist, American Heart Association, 2008

Michael Bonios:
Sidney Blumenthal Young Investigator Award, Blumenthal Family Foundation, 2008

John Terrovitis:
Melvin Judkins Young Investigator Award, American Heart Association, 2007

Marvin Chang:
Young Investigator Award Finalist, Heart Rhythm Society, 2007

Linmiao Xu:
Provost Award, Johns Hopkins University, 2007

Roselle Abraham:
Melvin Marcus Young Investigator Award Finalist, American Heart Association, 2004