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Heart & Vascular Institute

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Paolocci Lab Publications

Selected Publications:

  1. Paolocci N., Ekelund U.E.G., Isoda T., Ozaki M., Vandegaer K., Georgakopoulos D., Harrison R., Kass D.A., Hare M.J. Cyclic nucleotide independent positive inotropic effects of nitric oxide donors: potential role for nitrosylation. Am J Physiol. (Heart Circ. Physiol.) 279: H1982-1988, 2000.

  2. Paolocci N., Pagliaro P., Isoda T., Saavedra, W.F., Kass D.A. Role of calcium-sensitive K+-channels and nitric oxide in in vivo coronary vasodilation from enhanced perfusion pulsatility. Circulation. 103: 119-124, 2001.

  3. Paolocci N., Biondi R., Bettini M., Chang-Il Lee, Berlowitz CO, Rossi R., Xia Y., Ambrosio G., L’Abbate A., Kass D.A., Zweier J.L. Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart. J. Mol. Cell. Cardiol. 33: 671-679, 2001.

  4. Paolocci N., Saavedra W.F., Miranda K.M., Martignani C., Isoda T., Espey M.G., Hare J.M., Fukuto J.M., Feelisch M., Wink D.A., Kass D.A. Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling. Proc.Natl.Acad.Sci.USA. 98 (18):10463-10468, 2001.

  5. Saavedra, W.F., Paolocci N., St. John M.E., Skaf M.W., Stewart G.C., Xie J-S., Harrison R.W., Zeichner, J., Mudrick, D., Marban, E., Kass, D.A. Hare, J.M. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ. Res. 90:297-304, 2002.

  6. Thomas D., Miranda K.M., Espey M.G., Citrin D., Jourd’Heuil D., Paolocci N., Hewett S., Colton C., Grisham M., Feelisch M., Wink D.A. A guide to the use of nitric oxide donors as probes of the chemistry of NO and related redox species in biological systems. Methods in Enzymology, vol. 359: 84-105, 2002.

  7. Pagliaro P., Mancardi D., Rastaldo R., Penna C., Gattullo D., Miranda K.M., Feelisch M., Wink D.A., Kass D.A., Paolocci N. Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Rad Biol & Med. 34 (1): 33-43, 2003.

  8. Miranda K.M., Nims R.W., Thomas D.D., Espey M.G., Citrin D., Bartberger M.D., Paolocci N., Fukuto J.M., Feelisch M., Wink D.A. Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. J. Inorganic Biochem. 93 (1-2): 52-60, 2003.

  9. Paolocci N., Katori T., Champion H.C., St. John M.E., Miranda K.M., Jon M., Fukuto, Wink D.A., Kass, D.A. Positive inotropic and lusitropic effects of HNO/NO- in the failing heart: independence from ?-adrenergic signaling. Proc.Natl.Acad.Sci.USA. 100 (9): 5537-5542, 2003. Editorial by M. Feelisch. Nitroxyl gets to the heart of the matter. PNAS 2003;100(9):4978-80.

  10. Miranda K.M., Paolocci N., Katori T., Thomas D.D, Bartberger M.D, Espey M.G, Kass D.A., Feelisch M., Fukuto J.M., Wink D.A. A biochemical rationale for the orthogonal behavior of nitroxyl and nitric oxide in the cardiovascular system. Proc.Natl.Acad.Sci.USA. 100(16): 9196 201, 2003.

  11. Wink D.A., Miranda K.M., Katori T., Mancardi D., Thomas D.D., Ridnour L., Espey M.G., Feelisch M., Colton C.A., Fukuto J.M., Kass D.A., Paolocci N. The Orthogonal Properties of the Redox Siblings Nitroxyl (HNO) and Nitric Oxide (NO) in the Cardiovascular System: A Novel Redox Paradigm. Am. J. Physiol. 285: H2264-H2276, 2003.

  12. 1Katori T., Hoover D.B., Ardell J.L., Helm R.H., Belardi D.F., Tocchetti C.G., Forfia P.A., Kass D.A., Paolocci N. Calcitonin gene-related peptide in vivo positive inotropy is due to regional sympatho-stimulation and is blunted in congestive heart failure. Circ. Res. Dec 9, 2004 [Epub ahead of print]; 96 (2): 234-243, 2005.

  13. Miranda KM, Dutton AS, Ridnour LA, Foreman CA, Ford E, Paolocci N, Katori T, Tocchetti CG, Mancardi D, Thomas DD, Espey MG, Houk KN, Fukuto JM, Wink DA. Mechanism of Aerobic Decomposition of Angeli's Salt (Sodium Trioxodinitrate) at Physiological pH. J. Am. Chem. Soc. 127(2):722-731, 2005.

  14. Takimoto E., Champion H.C., Li M., Ren S., Rodriguez E.R., Tavazzi B., Lazzarino G., Paolocci N., Gabrielson K.L., Wang Y., Kass D.A. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure-load. J. Clin. Invest. 115(5):1221-1231, 2005. Epub 2005 Apr 14.

  15. Miranda K.M., Katori T., Torres de Holding C.L., Thomas L., Ridnour L.A., McLendon W.J., Dutton A.S., Champion H.C., Mancardi D., Tocchetti C.G., Saavedra J.E., Keefer L.K., Houk K.N., Fukuto J.M., Kass D.A. Paolocci N., Wink D.A. Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in vivo. J. Med. Chem. 48(26): 8220-8228, 2005.

  16. Mongillo M., Tocchetti C.G., Terrin A., Lissandron V., Cheung Y-F., Dostmann W.R., Pozzan T., Kass D.A., Paolocci N., Houslay M.D., Zaccolo M. Compartimentalised phosphodiesterase-2 (PDE2) activity blunts ?-adrenergic cardiac inotropy via a ?3-adrenoceptor/NO/cGMP dependent pathway. Circ. Res. 98(2):226-34, 2006 (Epub 2005 Dec 15).

  17. Donzelli S., Espey M.G., Thomas D.D., Mancardi D., Tocchetti C.G., Ridnour L.A., Paolocci N, King B.S., Miranda K.M., Lazzarino G., Fukuto J.M., Wink D.A. Discriminating formation of HNO from reactive nitrogen oxide species. Free Rad. Biol. Med. 40(6): 1056-1066, 2006.

  18. Paolocci N., Tavazzi B., Biondi R., Gluzband Y.A., Amorini A.M., Tocchetti C.G., Hejazi M., Caturegli P.M., Kajstura J., Lazzarino G., Kass D.A. Novel effect of metalloproteinase inhibition on myocardial high energy metabolism in sub-acute cardiac failure: potential role in enhancing diastolic compliance. J. Pharm. Exp. Therap. 317: 506-513, 2006.

  19. Katori T., Donzelli S., Tocchetti C.G., Miranda K.M., Cormaci G., Thomas D.D., Ketner E.A., Lee M. J., Mancardi D., Wink D.A., Kass D.A., Paolocci N. Peroxynitrite and myocardial contractility: in vivo versus in vitro effects Free Rad. Biol. Med. 41(10): 1606-1618, 2006.

  20. Tocchetti C.G., Wang W., Froehlich J.P., Huke S., Aon M.A., Wilson G.M., Di Benedetto G., O’ Rourke B., Gao W-D, Wink D.A., Toscano J.P., Zaccolo M., Bers D.M., Valdivia H.H., Cheng H., Kass D.A., Paolocci N. Nitroxyl improves cellular heart function by directly enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling. Circ Res. 100(1): 96-104, 2007.

  21. Dai T., Tocchetti C.G., Kass, D.A., Paolocci N., Gao W.D. Increased Ca2+ responsiveness by HNO/NO- in cardiac muscle. J Physiol. 580(3): 951-960, 2007. Editorial by J.R. Solaro, J Physiol 580(Pt3): 697, 2007.

  22. Paolocci N., Jackson M.I., Lopez B.E., Tocchetti C.G., Miranda K.M., Wink D.A., Hobbs A., Fukuto J.M. The Pharmacology of Nitroxyl (HNO) and Its Therapeutic Potential: Not Just the Janus Face of NO. Pharmacology & Therapeutics. 113(2):442-58, 2007.

  23. Wink D.A., Paolocci N. Mother was right: eat your vegetables and do not spit! When oral nitrate helps with high blood pressure. Hypertension. 2008 Mar;51(3):617-9. Epub 2008 Feb 4.

  24. Fukuto J.M., Jackson M.I., Kaludercic N., Paolocci N. Examining Nitroxyl (HNO) in Biological Systems Methods in Enzymology 2008; 440: 411-31.

  25. Moens A.L., Takimoto E., Tocchetti C.G., Chakir K., Bedja D., Cormaci G., Ketner E.A., Majmudar M., Scollick C., Gabrielson K., Halushka M.K., Mitchell J.B., Biswal S., Channon K.M., Wolin M.S., Alp N.J., Paolocci N., Champion H.C., Kass D.A. Reversal of Cardiac Hypertrophy and Fibrosis from Pressure-Overload by Tetrahydrobiopterin: Efficacy of re-coupling nitric oxide synthase as a therapeutic strategy  Circulation 2008; 117 (20): 2626-36, 2008 May 12. [Epub ahead of print]

  26. Hoard J.L., Hoover D.B., Mabe A.M., Blakely R.D., Feng N., Paolocci N. Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors TrkA and p75. Neuroscience 2008; 156 (1): 129-142.

  27. Froehlich JP, Mahaney JE, Keceli G, Pavlos CM, Goldstein R, Redwood AJ, Sumbilla C, Lee DI, Tocchetti CG, Kass DA, Paolocci N, Toscano JP. Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl. Biochemistry, 2008 Dec 16;47(50):13150-2

  28. Paolocci N., Wink D.A. The shy Angeli and his elusive creature: the HNO route to vasodilation Am. J. Physiol. (Heart & Circulatory Physiol) 296(5): H1217-20, 2009.

  29. Switzer C.H., Flores-Santana W., Mancardi D., Donzelli S., Basudhar D., Ridnour L.A., Miranda K.M., Fukuto J.M., Paolocci N., Wink D.A. The Emergence of Nitroxyl (HNO) as a Pharmacological Agent BBA Energetics 1787(7): 835-40, 2009.

  30. Kohr M.J., Kaludercic N., Tocchetti C.G., Gao W.D., Kass D.A., Janssen P.M.L., Paolocci N., Ziolo M.T. Nitroxyl enhances cardiomyocyte [Ca2+] by exclusively targeting sarcoplasmic reticulum Ca2+ cycling. Front. Biosc. in press

  31. Kaludercic N., Takimoto E., Nagayama T., Lai E.W., Feng N., Bedja D., Chen K., Gabrielson K.L., Blakely L. R., Shih J.C., Pacak K., Kass D.A., Di Lisa F., Paolocci N. MAO-A mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ. Res. (revision resubmitted)